An immune-cell signature of bacterial sepsis

• Published in: Nature medicine Vol. 26; no. 3; pp. 333 - 340
• Main Authors: Reyes, Miguel, Filbin, Michael R., Bhattacharyya, Roby P., Billman, Kianna, Eisenhaure, Thomas, Hung, Deborah T., Levy, Bruce D., Baron, Rebecca M., Blainey, Paul C., Goldberg, Marcia B., Hacohen, Nir
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2020; Nature Publishing Group
• Subjects: 631/1647/514/1949; 631/250/2504/342; 692/308/53/2421; 692/420/256/1980; 692/699/255/1318; Bacteria; Bacteria - immunology; Bacterial diseases; Bacterial infections; Biomarkers - blood; Biomedical and Life Sciences; Biomedicine; Blood; Bone marrow; Bone Marrow Cells - metabolism; Cancer Research; CD14 antigen; Clustering; Cohort Studies; Dendritic cells; Disease control; Epigenesis, Genetic; Etiology; Gene expression; Gene Expression Profiling; Gene sequencing; Genetic aspects; Genomics; Geographical locations; Humans; Immune response; Immune system; Infectious Diseases; Letter; Leukocytes (mononuclear); Metabolic Diseases; Molecular Medicine; Monocytes; Monocytes - metabolism; Neurosciences; Patient outcomes; Peripheral blood mononuclear cells; Phenotypes; Reproducibility of Results; Ribonucleic acid; RNA; ROC Curve; Sepsis; Sepsis - blood; Sepsis - genetics; Sepsis - immunology; Sepsis - microbiology; Sequence Analysis, RNA; Signatures; Surface markers; Transcription; Transcription, Genetic; Transcriptomics; United States

Dysregulation of the immune response to bacterial infection can lead to sepsis, a condition with high mortality. Multiple whole-blood gene-expression studies have defined sepsis-associated molecular signatures, but have not resolved changes in transcriptional states of specific cell types. Here, we...