Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model

• Published in: Diabetes (New York, N.Y.) Vol. 59; no. 11; pp. 2916 - 2927
• Main Authors: Wang, Xiaoxin X., Jiang, Tao, Shen, Yan, Caldas, Yupanqui, Miyazaki-Anzai, Shinobu, Santamaria, Hannah, Urbanek, Cydney, Solis, Nathaniel, Scherzer, Pnina, Lewis, Linda, Gonzalez, Frank J., Adorini, Luciano, Pruzanski, Mark, Kopp, Jeffrey B., Verlander, Jill W., Levi, Moshe
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.11.2010
• Subjects: Animals; Associated diseases and complications; Binding proteins; Biological and medical sciences; Care and treatment; Cholesterol; Complications; Complications and side effects; Crosses, Genetic; Development and progression; Diabetes; Diabetes Mellitus, Experimental - pathology; Diabetes Mellitus, Experimental - physiopathology; Diabetes Mellitus, Type 1 - pathology; Diabetes Mellitus, Type 1 - physiopathology; Diabetes. Impaired glucose tolerance; Diabetic nephropathies; Diabetic Nephropathies - pathology; Diabetic Nephropathies - physiopathology; Diabetic Nephropathies - prevention & control; Diabetic nephropathy; DNA Primers; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Foam Cells - pathology; Genetic aspects; Glucose; Growth factors; House mouse; Hyperglycemia; Kidney - pathology; Kidney - physiopathology; Kidney diseases; Kidney Glomerulus - pathology; Kidneys; Lipids; Macrophages - pathology; Male; Medical sciences; Metabolism; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Microscopy; Nephrology. Urinary tract diseases; Oxidative stress; Pathogenesis; Physiological aspects; Polymerase Chain Reaction; Proteins; Receptors, Cytoplasmic and Nuclear - deficiency; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Cytoplasmic and Nuclear - physiology; Research design; Risk factors; Sterols; Type 1 diabetes; Urinary system involvement in other diseases. Miscellaneous; United States; St Louis Missouri; United States > US; Endocrinopathy; Kidney disease; Farnesoid X receptor; Immunopathology; Concomitant disease; Urinary system disease; Type 1 diabetes; Deficiency; Autoimmune disease; Diabetic nephropathy; Models

The pathogenesis of diabetic nephropathy is complex and involves activation of multiple pathways leading to kidney damage. An important role for altered lipid metabolism via sterol regulatory element binding proteins (SREBPs) has been recently recognized in diabetic kidney disease. Our previous stud...