Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity

Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well a...

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Published inNeuroImage clinical Vol. 8; no. C; pp. 1 - 31
Main Authors Val-Laillet, D., Aarts, E., Weber, B., Ferrari, M., Quaresima, V., Stoeckel, L.E., Alonso-Alonso, M., Audette, M., Malbert, C.H., Stice, E.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.01.2015
Elsevier
Subjects
aCC
HFD
TRD
PFC
STN
DBS
DBT
VNS
ED
VBM
EEG
AN
DTI
VN
MER
VS
VTA
LHA
CBF
ANT
OFC
MRS
BS
pCC
BMI
BED
HHb
GP
CCK
B N
vmH
Nac
OCD
PYY
PD
BAT
DAT
TMS
DA
PET
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Abstract Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at risk by exploring different neurobehavioral dimensions of the food choices and motivation processes. In the first part of this review, advantages and limitations of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), pharmacogenetic fMRI and functional near-infrared spectroscopy (fNIRS) will be discussed in the context of recent work dealing with eating behavior, with a particular focus on obesity. In the second part of the review, non-invasive strategies to modulate food-related brain processes and functions will be presented. At the leading edge of non-invasive brain-based technologies is real-time fMRI (rtfMRI) neurofeedback, which is a powerful tool to better understand the complexity of human brain–behavior relationships. rtfMRI, alone or when combined with other techniques and tools such as EEG and cognitive therapy, could be used to alter neural plasticity and learned behavior to optimize and/or restore healthy cognition and eating behavior. Other promising non-invasive neuromodulation approaches being explored are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). Converging evidence points at the value of these non-invasive neuromodulation strategies to study basic mechanisms underlying eating behavior and to treat its disorders. Both of these approaches will be compared in light of recent work in this field, while addressing technical and practical questions. The third part of this review will be dedicated to invasive neuromodulation strategies, such as vagus nerve stimulation (VNS) and deep brain stimulation (DBS). In combination with neuroimaging approaches, these techniques are promising experimental tools to unravel the intricate relationships between homeostatic and hedonic brain circuits. Their potential as additional therapeutic tools to combat pharmacorefractory morbid obesity or acute eating disorders will be discussed, in terms of technical challenges, applicability and ethics. In a general discussion, we will put the brain at the core of fundamental research, prevention and therapy in the context of obesity and eating disorders. First, we will discuss the possibility to identify new biological markers of brain functions. Second, we will highlight the potential of neuroimaging and neuromodulation in individualized medicine. Third, we will introduce the ethical questions that are concomitant to the emergence of new neuromodulation therapies. •We review the neural vulnerability factors related to obesity and eating disorders.•We compare the pros and cons of neuroimaging techniques to study eating behavior.•We present non-invasive strategies to modulate food-related brain processes.•We also present invasive neuromodulation methods such as VNS and DBS.•We discuss about neuroimaging and neuromodulation for prevention and therapy.
AbstractList Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at risk by exploring different neurobehavioral dimensions of the food choices and motivation processes. In the first part of this review, advantages and limitations of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), pharmacogenetic fMRI and functional near-infrared spectroscopy (fNIRS) will be discussed in the context of recent work dealing with eating behavior, with a particular focus on obesity. In the second part of the review, non-invasive strategies to modulate food-related brain processes and functions will be presented. At the leading edge of non-invasive brain-based technologies is real-time fMRI (rtfMRI) neurofeedback, which is a powerful tool to better understand the complexity of human brain-behavior relationships. rtfMRI, alone or when combined with other techniques and tools such as EEG and cognitive therapy, could be used to alter neural plasticity and learned behavior to optimize and/or restore healthy cognition and eating behavior. Other promising non-invasive neuromodulation approaches being explored are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). Converging evidence points at the value of these non-invasive neuromodulation strategies to study basic mechanisms underlying eating behavior and to treat its disorders. Both of these approaches will be compared in light of recent work in this field, while addressing technical and practical questions. The third part of this review will be dedicated to invasive neuromodulation strategies, such as vagus nerve stimulation (VNS) and deep brain stimulation (DBS). In combination with neuroimaging approaches, these techniques are promising experimental tools to unravel the intricate relationships between homeostatic and hedonic brain circuits. Their potential as additional therapeutic tools to combat pharmacorefractory morbid obesity or acute eating disorders will be discussed, in terms of technical challenges, applicability and ethics. In a general discussion, we will put the brain at the core of fundamental research, prevention and therapy in the context of obesity and eating disorders. First, we will discuss the possibility to identify new biological markers of brain functions. Second, we will highlight the potential of neuroimaging and neuromodulation in individualized medicine. Third, we will introduce the ethical questions that are concomitant to the emergence of new neuromodulation therapies.
Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at risk by exploring different neurobehavioral dimensions of the food choices and motivation processes. In the first part of this review, advantages and limitations of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), pharmacogenetic fMRI and functional near-infrared spectroscopy (fNIRS) will be discussed in the context of recent work dealing with eating behavior, with a particular focus on obesity. In the second part of the review, non-invasive strategies to modulate food-related brain processes and functions will be presented. At the leading edge of non-invasive brain-based technologies is real-time fMRI (rtfMRI) neurofeedback, which is a powerful tool to better understand the complexity of human brain–behavior relationships. rtfMRI, alone or when combined with other techniques and tools such as EEG and cognitive therapy, could be used to alter neural plasticity and learned behavior to optimize and/or restore healthy cognition and eating behavior. Other promising non-invasive neuromodulation approaches being explored are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). Converging evidence points at the value of these non-invasive neuromodulation strategies to study basic mechanisms underlying eating behavior and to treat its disorders. Both of these approaches will be compared in light of recent work in this field, while addressing technical and practical questions. The third part of this review will be dedicated to invasive neuromodulation strategies, such as vagus nerve stimulation (VNS) and deep brain stimulation (DBS). In combination with neuroimaging approaches, these techniques are promising experimental tools to unravel the intricate relationships between homeostatic and hedonic brain circuits. Their potential as additional therapeutic tools to combat pharmacorefractory morbid obesity or acute eating disorders will be discussed, in terms of technical challenges, applicability and ethics. In a general discussion, we will put the brain at the core of fundamental research, prevention and therapy in the context of obesity and eating disorders. First, we will discuss the possibility to identify new biological markers of brain functions. Second, we will highlight the potential of neuroimaging and neuromodulation in individualized medicine. Third, we will introduce the ethical questions that are concomitant to the emergence of new neuromodulation therapies. •We review the neural vulnerability factors related to obesity and eating disorders.•We compare the pros and cons of neuroimaging techniques to study eating behavior.•We present non-invasive strategies to modulate food-related brain processes.•We also present invasive neuromodulation methods such as VNS and DBS.•We discuss about neuroimaging and neuromodulation for prevention and therapy.
Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at risk by exploring different neurobehavioral dimensions of the food choices and motivation processes. In the first part of this review, advantages and limitations of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), pharmacogenetic fMRI and functional near-infrared spectroscopy (fNIRS) will be discussed in the context of recent work dealing with eating behavior, with a particular focus on obesity. In the second part of the review, non-invasive strategies to modulate food-related brain processes and functions will be presented. At the leading edge of non-invasive brain-based technologies is real-time fMRI (rtfMRI) neurofeedback, which is a powerful tool to better understand the complexity of human brain–behavior relationships. rtfMRI, alone or when combined with other techniques and tools such as EEG and cognitive therapy, could be used to alter neural plasticity and learned behavior to optimize and/or restore healthy cognition and eating behavior. Other promising non-invasive neuromodulation approaches being explored are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). Converging evidence points at the value of these non-invasive neuromodulation strategies to study basic mechanisms underlying eating behavior and to treat its disorders. Both of these approaches will be compared in light of recent work in this field, while addressing technical and practical questions. The third part of this review will be dedicated to invasive neuromodulation strategies, such as vagus nerve stimulation (VNS) and deep brain stimulation (DBS). In combination with neuroimaging approaches, these techniques are promising experimental tools to unravel the intricate relationships between homeostatic and hedonic brain circuits. Their potential as additional therapeutic tools to combat pharmacorefractory morbid obesity or acute eating disorders will be discussed, in terms of technical challenges, applicability and ethics. In a general discussion, we will put the brain at the core of fundamental research, prevention and therapy in the context of obesity and eating disorders. First, we will discuss the possibility to identify new biological markers of brain functions. Second, we will highlight the potential of neuroimaging and neuromodulation in individualized medicine. Third, we will introduce the ethical questions that are concomitant to the emergence of new neuromodulation therapies. • We review the neural vulnerability factors related to obesity and eating disorders. • We compare the pros and cons of neuroimaging techniques to study eating behavior. • We present non-invasive strategies to modulate food-related brain processes. • We also present invasive neuromodulation methods such as VNS and DBS. • We discuss about neuroimaging and neuromodulation for prevention and therapy.
AbstractFunctional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at risk by exploring different neurobehavioral dimensions of the food choices and motivation processes. In the first part of this review, advantages and limitations of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), pharmacogenetic fMRI and functional near-infrared spectroscopy (fNIRS) will be discussed in the context of recent work dealing with eating behavior, with a particular focus on obesity. In the second part of the review, non-invasive strategies to modulate food-related brain processes and functions will be presented. At the leading edge of non-invasive brain-based technologies is real-time fMRI (rtfMRI) neurofeedback, which is a powerful tool to better understand the complexity of human brain–behavior relationships. rtfMRI, alone or when combined with other techniques and tools such as EEG and cognitive therapy, could be used to alter neural plasticity and learned behavior to optimize and/or restore healthy cognition and eating behavior. Other promising non-invasive neuromodulation approaches being explored are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). Converging evidence points at the value of these non-invasive neuromodulation strategies to study basic mechanisms underlying eating behavior and to treat its disorders. Both of these approaches will be compared in light of recent work in this field, while addressing technical and practical questions. The third part of this review will be dedicated to invasive neuromodulation strategies, such as vagus nerve stimulation (VNS) and deep brain stimulation (DBS). In combination with neuroimaging approaches, these techniques are promising experimental tools to unravel the intricate relationships between homeostatic and hedonic brain circuits. Their potential as additional therapeutic tools to combat pharmacorefractory morbid obesity or acute eating disorders will be discussed, in terms of technical challenges, applicability and ethics. In a general discussion, we will put the brain at the core of fundamental research, prevention and therapy in the context of obesity and eating disorders. First, we will discuss the possibility to identify new biological markers of brain functions. Second, we will highlight the potential of neuroimaging and neuromodulation in individualized medicine. Third, we will introduce the ethical questions that are concomitant to the emergence of new neuromodulation therapies.
Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at risk by exploring different neurobehavioral dimensions of the food choices and motivation processes. In the first part of this review, advantages and limitations of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), pharmacogenetic fMRI and functional near-infrared spectroscopy (fNIRS) will be discussed in the context of recent work dealing with eating behavior, with a particular focus on obesity. In the second part of the review, non-invasive strategies to modulate food-related brain processes and functions will be presented. At the leading edge of non-invasive brain-based technologies is real-time fMRI (rtfMRI) neurofeedback, which is a powerful tool to better understand the complexity of human brain-behavior relationships. rtfMRI, alone or when combined with other techniques and tools such as EEG and cognitive therapy, could be used to alter neural plasticity and learned behavior to optimize and/or restore healthy cognition and eating behavior. Other promising non-invasive neuromodulation approaches being explored are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). Converging evidence points at the value of these non-invasive neuromodulation strategies to study basic mechanisms underlying eating behavior and to treat its disorders. Both of these approaches will be compared in light of recent work in this field, while addressing technical and practical questions. The third part of this review will be dedicated to invasive neuromodulation strategies, such as vagus nerve stimulation (VNS) and deep brain stimulation (DBS). In combination with neuroimaging approaches, these techniques are promising experimental tools to unravel the intricate relationships between homeostatic and hedonic brain circuits. Their potential as additional therapeutic tools to combat pharmacorefractory morbid obesity or acute eating disorders will be discussed, in terms of technical challenges, applicability and ethics. In a general discussion, we will put the brain at the core of fundamental research, prevention and therapy in the context of obesity and eating disorders. First, we will discuss the possibility to identify new biological markers of brain functions. Second, we will highlight the potential of neuroimaging and neuromodulation in individualized medicine. Third, we will introduce the ethical questions that are concomitant to the emergence of new neuromodulation therapies.Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at risk by exploring different neurobehavioral dimensions of the food choices and motivation processes. In the first part of this review, advantages and limitations of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), pharmacogenetic fMRI and functional near-infrared spectroscopy (fNIRS) will be discussed in the context of recent work dealing with eating behavior, with a particular focus on obesity. In the second part of the review, non-invasive strategies to modulate food-related brain processes and functions will be presented. At the leading edge of non-invasive brain-based technologies is real-time fMRI (rtfMRI) neurofeedback, which is a powerful tool to better understand the complexity of human brain-behavior relationships. rtfMRI, alone or when combined with other techniques and tools such as EEG and cognitive therapy, could be used to alter neural plasticity and learned behavior to optimize and/or restore healthy cognition and eating behavior. Other promising non-invasive neuromodulation approaches being explored are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). Converging evidence points at the value of these non-invasive neuromodulation strategies to study basic mechanisms underlying eating behavior and to treat its disorders. Both of these approaches will be compared in light of recent work in this field, while addressing technical and practical questions. The third part of this review will be dedicated to invasive neuromodulation strategies, such as vagus nerve stimulation (VNS) and deep brain stimulation (DBS). In combination with neuroimaging approaches, these techniques are promising experimental tools to unravel the intricate relationships between homeostatic and hedonic brain circuits. Their potential as additional therapeutic tools to combat pharmacorefractory morbid obesity or acute eating disorders will be discussed, in terms of technical challenges, applicability and ethics. In a general discussion, we will put the brain at the core of fundamental research, prevention and therapy in the context of obesity and eating disorders. First, we will discuss the possibility to identify new biological markers of brain functions. Second, we will highlight the potential of neuroimaging and neuromodulation in individualized medicine. Third, we will introduce the ethical questions that are concomitant to the emergence of new neuromodulation therapies.
Author Alonso-Alonso, M.
Malbert, C.H.
Quaresima, V.
Stoeckel, L.E.
Audette, M.
Ferrari, M.
Aarts, E.
Stice, E.
Weber, B.
Val-Laillet, D.
AuthorAffiliation i Oregon Research Institute, USA
e Massachusetts General Hospital, Harvard Medical School, USA
f Beth Israel Deaconess Medical Center, Harvard Medical School, USA
d Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy
b Radboud University, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
h INRA, US1395 Ani-Scans, France
c Department of Epileptology, University Hospital Bonn, Germany
g Old Dominion University, USA
a INRA, UR1341 ADNC, France
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– name: i Oregon Research Institute, USA
– name: c Department of Epileptology, University Hospital Bonn, Germany
– name: g Old Dominion University, USA
– name: d Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy
– name: e Massachusetts General Hospital, Harvard Medical School, USA
– name: f Beth Israel Deaconess Medical Center, Harvard Medical School, USA
– name: b Radboud University, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
– name: h INRA, US1395 Ani-Scans, France
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  organization: INRA, UR1341 ADNC, France
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  organization: Radboud University, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
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  organization: Department of Epileptology, University Hospital Bonn, Germany
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  surname: Ferrari
  fullname: Ferrari, M.
  organization: Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy
– sequence: 5
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  surname: Quaresima
  fullname: Quaresima, V.
  organization: Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy
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  fullname: Stoeckel, L.E.
  organization: Massachusetts General Hospital, Harvard Medical School, USA
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  surname: Alonso-Alonso
  fullname: Alonso-Alonso, M.
  organization: Beth Israel Deaconess Medical Center, Harvard Medical School, USA
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  orcidid: 0000-0003-0011-1731
  surname: Audette
  fullname: Audette, M.
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  orcidid: 0000-0002-0665-4545
  surname: Malbert
  fullname: Malbert, C.H.
  organization: INRA, US1395 Ani-Scans, France
– sequence: 10
  givenname: E.
  surname: Stice
  fullname: Stice, E.
  organization: Oregon Research Institute, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26110109$$D View this record in MEDLINE/PubMed
https://hal.science/hal-01417725$$DView record in HAL
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Issue C
Keywords aCC
Brain
HFD
TRD
HD-tDCS
PFC
STN
Neuromodulation
lPFC
DBS
tRNS
DBT
BOLD
VNS
ED
VBM
Human
rCBF
Obesity
EEG
vlPFC
AN
fMRI
daCC
dlPFC
DTI
dTMS
VN
O2Hb
MER
5-HT
VS
Neuroimaging
ADHD
VTA
LHA
CBF
ANT
vmPFC
tACS
OFC
SPECT
MRS
BS
pCC
Cg25
BMI
BED
fNIRS
HHb
Eating disorders
GP
CCK
B N
vmH
Nac
OCD
PYY
PD
BAT
tDCS
DAT
rtfMRI
TMS
DA
rTMS
PET
Parkinson's disease
attention deficit hyperactivity disorder
magnetic resonance spectroscopy
eating disorders
transcranial magnetic stimulation
serotonin
O 2Hb
transcranial random noise stimulation
orbitofrontal cortex
transcranial alternate current stimulation
anterior cingulate cortex
bulimia nervosa
subgenual cingulate cortex
blood oxygenation level dependent
treatment-resistant depression
cerebral blood flow
cholecystokinin
deoxygenated-hemoglobin
obsessive–compulsive disorder
dorsal anterior cingulate cortex
vagus nerve
binge eating disorder
deep brain therapy
ventromedial hypothalamus
vagus nerve stimulation
lateral prefrontal cortex
dopamine transporter
brown adipose tissue
ventromedial prefrontal cortex
regional cerebral blood flow
dopamine
ventral striatum
peptide tyrosine tyrosine
anterior nucleus of the thalamus
dorsolateral prefrontal cortex
transcranial direct current stimulation
ventrolateral prefrontal cortex
globus pallidus
repetitive transcranial magnetic stimulation
body mass index
single photon emission computed tomography
nucleus accumbens
deep brain stimulation
ventral tegmental area
functional near-infrared spectroscopy
subthalamic nucleus
high-fat diet
diffusion tensor imaging
functional magnetic resonance imaging
prefrontal cortex
lateral hypothalamus
anorexia nervosa
oxygenated-hemoglobin
posterior cingulate cortex
electroencephalography
microelectrode recording
bariatric surgery
deep transcranial magnetic stimulation
voxel-based morphometry
real-time functional magnetic resonance imaging
high-definition transcranial direct current stimulation
positron emission tomography
VN, vagus nerve
DBS, deep brain stimulation
VS, ventral striatum
rtfMRI, real-time functional magnetic resonance imaging
tDCS, transcranial direct current stimulation
TMS, transcranial magnetic stimulation
STN, subthalamic nucleus
VBM, voxel-based morphometry
BMI, body mass index
BED, binge eating disorder
GP, globus pallidus
tACS, transcranial alternate current stimulation
MRS, magnetic resonance spectroscopy
pCC, posterior cingulate cortex
HD-tDCS, high-definition transcranial direct current stimulation
DA, dopamine
DAT, dopamine transporter
PET, positron emission tomography
HHb, deoxygenated-hemoglobin
OFC, orbitofrontal cortex
SPECT, single photon emission computed tomography
CCK, cholecystokinin
fMRI, functional magnetic resonance imaging
tRNS, transcranial random noise stimulation
CBF, cerebral blood flow
B N, bulimia nervosa
EEG, electroencephalography
PD, Parkinson's disease
BOLD, blood oxygenation level dependent
ANT, anterior nucleus of the thalamus
TRD, treatment-resistant depression
dlPFC, dorsolateral prefrontal cortex
ED, eating disorders
VNS, vagus nerve stimulation
OCD, obsessive–compulsive disorder
PFC, prefrontal cortex
Nac, nucleus accumbens
ADHD, attention deficit hyperactivity disorder
Cg25, subgenual cingulate cortex
LHA, lateral hypothalamus
VTA, ventral tegmental area
fNIRS, functional near-infrared spectroscopy
aCC, anterior cingulate cortex
HFD, high-fat diet
5-HT, serotonin
dTMS, deep transcranial magnetic stimulation
rCBF, regional cerebral blood flow
O2Hb, oxygenated-hemoglobin
lPFC, lateral prefrontal cortex
BS, bariatric surgery
AN, anorexia nervosa
BAT, brown adipose tissue
vmH, ventromedial hypothalamus
DBT, deep brain therapy
PYY, peptide tyrosine tyrosine
daCC, dorsal anterior cingulate cortex
MER, microelectrode recording
vlPFC, ventrolateral prefrontal cortex
vmPFC, ventromedial prefrontal cortex
DTI, diffusion tensor imaging
rTMS, repetitive transcranial magnetic stimulation
comportement alimentaire
trouble alimentaire
human health
hyperphagia
homme
cerveau
imagerie cerebrale
obésité
fonction cérébrale
santé humaine
food habits
human
Language English
License http://creativecommons.org/licenses/by-nc-nd/4.0
Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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Snippet Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating...
AbstractFunctional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and...
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SubjectTerms Brain
Brain - physiopathology
Eating disorders
Electric Stimulation Therapy - methods
Electroencephalography - methods
Feeding and Eating Disorders - physiopathology
Feeding and Eating Disorders - prevention & control
Feeding and Eating Disorders - therapy
Feeding Behavior - physiology
Human
Humans
Life Sciences
Neurofeedback - methods
Neuroimaging
Neuroimaging - methods
Neuromodulation
Obesity
Obesity - physiopathology
Obesity - prevention & control
Obesity - therapy
Radiology
Review
Transcranial Magnetic Stimulation - methods
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Title Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity
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