Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity
Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well a...
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Published in | NeuroImage clinical Vol. 8; no. C; pp. 1 - 31 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Inc
01.01.2015
Elsevier |
Subjects | |
Online Access | Get full text |
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Abstract | Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at risk by exploring different neurobehavioral dimensions of the food choices and motivation processes. In the first part of this review, advantages and limitations of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), pharmacogenetic fMRI and functional near-infrared spectroscopy (fNIRS) will be discussed in the context of recent work dealing with eating behavior, with a particular focus on obesity. In the second part of the review, non-invasive strategies to modulate food-related brain processes and functions will be presented. At the leading edge of non-invasive brain-based technologies is real-time fMRI (rtfMRI) neurofeedback, which is a powerful tool to better understand the complexity of human brain–behavior relationships. rtfMRI, alone or when combined with other techniques and tools such as EEG and cognitive therapy, could be used to alter neural plasticity and learned behavior to optimize and/or restore healthy cognition and eating behavior. Other promising non-invasive neuromodulation approaches being explored are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). Converging evidence points at the value of these non-invasive neuromodulation strategies to study basic mechanisms underlying eating behavior and to treat its disorders. Both of these approaches will be compared in light of recent work in this field, while addressing technical and practical questions. The third part of this review will be dedicated to invasive neuromodulation strategies, such as vagus nerve stimulation (VNS) and deep brain stimulation (DBS). In combination with neuroimaging approaches, these techniques are promising experimental tools to unravel the intricate relationships between homeostatic and hedonic brain circuits. Their potential as additional therapeutic tools to combat pharmacorefractory morbid obesity or acute eating disorders will be discussed, in terms of technical challenges, applicability and ethics. In a general discussion, we will put the brain at the core of fundamental research, prevention and therapy in the context of obesity and eating disorders. First, we will discuss the possibility to identify new biological markers of brain functions. Second, we will highlight the potential of neuroimaging and neuromodulation in individualized medicine. Third, we will introduce the ethical questions that are concomitant to the emergence of new neuromodulation therapies.
•We review the neural vulnerability factors related to obesity and eating disorders.•We compare the pros and cons of neuroimaging techniques to study eating behavior.•We present non-invasive strategies to modulate food-related brain processes.•We also present invasive neuromodulation methods such as VNS and DBS.•We discuss about neuroimaging and neuromodulation for prevention and therapy. |
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AbstractList | Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at risk by exploring different neurobehavioral dimensions of the food choices and motivation processes. In the first part of this review, advantages and limitations of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), pharmacogenetic fMRI and functional near-infrared spectroscopy (fNIRS) will be discussed in the context of recent work dealing with eating behavior, with a particular focus on obesity. In the second part of the review, non-invasive strategies to modulate food-related brain processes and functions will be presented. At the leading edge of non-invasive brain-based technologies is real-time fMRI (rtfMRI) neurofeedback, which is a powerful tool to better understand the complexity of human brain-behavior relationships. rtfMRI, alone or when combined with other techniques and tools such as EEG and cognitive therapy, could be used to alter neural plasticity and learned behavior to optimize and/or restore healthy cognition and eating behavior. Other promising non-invasive neuromodulation approaches being explored are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). Converging evidence points at the value of these non-invasive neuromodulation strategies to study basic mechanisms underlying eating behavior and to treat its disorders. Both of these approaches will be compared in light of recent work in this field, while addressing technical and practical questions. The third part of this review will be dedicated to invasive neuromodulation strategies, such as vagus nerve stimulation (VNS) and deep brain stimulation (DBS). In combination with neuroimaging approaches, these techniques are promising experimental tools to unravel the intricate relationships between homeostatic and hedonic brain circuits. Their potential as additional therapeutic tools to combat pharmacorefractory morbid obesity or acute eating disorders will be discussed, in terms of technical challenges, applicability and ethics. In a general discussion, we will put the brain at the core of fundamental research, prevention and therapy in the context of obesity and eating disorders. First, we will discuss the possibility to identify new biological markers of brain functions. Second, we will highlight the potential of neuroimaging and neuromodulation in individualized medicine. Third, we will introduce the ethical questions that are concomitant to the emergence of new neuromodulation therapies. Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at risk by exploring different neurobehavioral dimensions of the food choices and motivation processes. In the first part of this review, advantages and limitations of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), pharmacogenetic fMRI and functional near-infrared spectroscopy (fNIRS) will be discussed in the context of recent work dealing with eating behavior, with a particular focus on obesity. In the second part of the review, non-invasive strategies to modulate food-related brain processes and functions will be presented. At the leading edge of non-invasive brain-based technologies is real-time fMRI (rtfMRI) neurofeedback, which is a powerful tool to better understand the complexity of human brain–behavior relationships. rtfMRI, alone or when combined with other techniques and tools such as EEG and cognitive therapy, could be used to alter neural plasticity and learned behavior to optimize and/or restore healthy cognition and eating behavior. Other promising non-invasive neuromodulation approaches being explored are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). Converging evidence points at the value of these non-invasive neuromodulation strategies to study basic mechanisms underlying eating behavior and to treat its disorders. Both of these approaches will be compared in light of recent work in this field, while addressing technical and practical questions. The third part of this review will be dedicated to invasive neuromodulation strategies, such as vagus nerve stimulation (VNS) and deep brain stimulation (DBS). In combination with neuroimaging approaches, these techniques are promising experimental tools to unravel the intricate relationships between homeostatic and hedonic brain circuits. Their potential as additional therapeutic tools to combat pharmacorefractory morbid obesity or acute eating disorders will be discussed, in terms of technical challenges, applicability and ethics. In a general discussion, we will put the brain at the core of fundamental research, prevention and therapy in the context of obesity and eating disorders. First, we will discuss the possibility to identify new biological markers of brain functions. Second, we will highlight the potential of neuroimaging and neuromodulation in individualized medicine. Third, we will introduce the ethical questions that are concomitant to the emergence of new neuromodulation therapies. •We review the neural vulnerability factors related to obesity and eating disorders.•We compare the pros and cons of neuroimaging techniques to study eating behavior.•We present non-invasive strategies to modulate food-related brain processes.•We also present invasive neuromodulation methods such as VNS and DBS.•We discuss about neuroimaging and neuromodulation for prevention and therapy. Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at risk by exploring different neurobehavioral dimensions of the food choices and motivation processes. In the first part of this review, advantages and limitations of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), pharmacogenetic fMRI and functional near-infrared spectroscopy (fNIRS) will be discussed in the context of recent work dealing with eating behavior, with a particular focus on obesity. In the second part of the review, non-invasive strategies to modulate food-related brain processes and functions will be presented. At the leading edge of non-invasive brain-based technologies is real-time fMRI (rtfMRI) neurofeedback, which is a powerful tool to better understand the complexity of human brain–behavior relationships. rtfMRI, alone or when combined with other techniques and tools such as EEG and cognitive therapy, could be used to alter neural plasticity and learned behavior to optimize and/or restore healthy cognition and eating behavior. Other promising non-invasive neuromodulation approaches being explored are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). Converging evidence points at the value of these non-invasive neuromodulation strategies to study basic mechanisms underlying eating behavior and to treat its disorders. Both of these approaches will be compared in light of recent work in this field, while addressing technical and practical questions. The third part of this review will be dedicated to invasive neuromodulation strategies, such as vagus nerve stimulation (VNS) and deep brain stimulation (DBS). In combination with neuroimaging approaches, these techniques are promising experimental tools to unravel the intricate relationships between homeostatic and hedonic brain circuits. Their potential as additional therapeutic tools to combat pharmacorefractory morbid obesity or acute eating disorders will be discussed, in terms of technical challenges, applicability and ethics. In a general discussion, we will put the brain at the core of fundamental research, prevention and therapy in the context of obesity and eating disorders. First, we will discuss the possibility to identify new biological markers of brain functions. Second, we will highlight the potential of neuroimaging and neuromodulation in individualized medicine. Third, we will introduce the ethical questions that are concomitant to the emergence of new neuromodulation therapies. • We review the neural vulnerability factors related to obesity and eating disorders. • We compare the pros and cons of neuroimaging techniques to study eating behavior. • We present non-invasive strategies to modulate food-related brain processes. • We also present invasive neuromodulation methods such as VNS and DBS. • We discuss about neuroimaging and neuromodulation for prevention and therapy. AbstractFunctional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at risk by exploring different neurobehavioral dimensions of the food choices and motivation processes. In the first part of this review, advantages and limitations of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), pharmacogenetic fMRI and functional near-infrared spectroscopy (fNIRS) will be discussed in the context of recent work dealing with eating behavior, with a particular focus on obesity. In the second part of the review, non-invasive strategies to modulate food-related brain processes and functions will be presented. At the leading edge of non-invasive brain-based technologies is real-time fMRI (rtfMRI) neurofeedback, which is a powerful tool to better understand the complexity of human brain–behavior relationships. rtfMRI, alone or when combined with other techniques and tools such as EEG and cognitive therapy, could be used to alter neural plasticity and learned behavior to optimize and/or restore healthy cognition and eating behavior. Other promising non-invasive neuromodulation approaches being explored are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). Converging evidence points at the value of these non-invasive neuromodulation strategies to study basic mechanisms underlying eating behavior and to treat its disorders. Both of these approaches will be compared in light of recent work in this field, while addressing technical and practical questions. The third part of this review will be dedicated to invasive neuromodulation strategies, such as vagus nerve stimulation (VNS) and deep brain stimulation (DBS). In combination with neuroimaging approaches, these techniques are promising experimental tools to unravel the intricate relationships between homeostatic and hedonic brain circuits. Their potential as additional therapeutic tools to combat pharmacorefractory morbid obesity or acute eating disorders will be discussed, in terms of technical challenges, applicability and ethics. In a general discussion, we will put the brain at the core of fundamental research, prevention and therapy in the context of obesity and eating disorders. First, we will discuss the possibility to identify new biological markers of brain functions. Second, we will highlight the potential of neuroimaging and neuromodulation in individualized medicine. Third, we will introduce the ethical questions that are concomitant to the emergence of new neuromodulation therapies. Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at risk by exploring different neurobehavioral dimensions of the food choices and motivation processes. In the first part of this review, advantages and limitations of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), pharmacogenetic fMRI and functional near-infrared spectroscopy (fNIRS) will be discussed in the context of recent work dealing with eating behavior, with a particular focus on obesity. In the second part of the review, non-invasive strategies to modulate food-related brain processes and functions will be presented. At the leading edge of non-invasive brain-based technologies is real-time fMRI (rtfMRI) neurofeedback, which is a powerful tool to better understand the complexity of human brain-behavior relationships. rtfMRI, alone or when combined with other techniques and tools such as EEG and cognitive therapy, could be used to alter neural plasticity and learned behavior to optimize and/or restore healthy cognition and eating behavior. Other promising non-invasive neuromodulation approaches being explored are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). Converging evidence points at the value of these non-invasive neuromodulation strategies to study basic mechanisms underlying eating behavior and to treat its disorders. Both of these approaches will be compared in light of recent work in this field, while addressing technical and practical questions. The third part of this review will be dedicated to invasive neuromodulation strategies, such as vagus nerve stimulation (VNS) and deep brain stimulation (DBS). In combination with neuroimaging approaches, these techniques are promising experimental tools to unravel the intricate relationships between homeostatic and hedonic brain circuits. Their potential as additional therapeutic tools to combat pharmacorefractory morbid obesity or acute eating disorders will be discussed, in terms of technical challenges, applicability and ethics. In a general discussion, we will put the brain at the core of fundamental research, prevention and therapy in the context of obesity and eating disorders. First, we will discuss the possibility to identify new biological markers of brain functions. Second, we will highlight the potential of neuroimaging and neuromodulation in individualized medicine. Third, we will introduce the ethical questions that are concomitant to the emergence of new neuromodulation therapies.Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at risk by exploring different neurobehavioral dimensions of the food choices and motivation processes. In the first part of this review, advantages and limitations of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), pharmacogenetic fMRI and functional near-infrared spectroscopy (fNIRS) will be discussed in the context of recent work dealing with eating behavior, with a particular focus on obesity. In the second part of the review, non-invasive strategies to modulate food-related brain processes and functions will be presented. At the leading edge of non-invasive brain-based technologies is real-time fMRI (rtfMRI) neurofeedback, which is a powerful tool to better understand the complexity of human brain-behavior relationships. rtfMRI, alone or when combined with other techniques and tools such as EEG and cognitive therapy, could be used to alter neural plasticity and learned behavior to optimize and/or restore healthy cognition and eating behavior. Other promising non-invasive neuromodulation approaches being explored are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). Converging evidence points at the value of these non-invasive neuromodulation strategies to study basic mechanisms underlying eating behavior and to treat its disorders. Both of these approaches will be compared in light of recent work in this field, while addressing technical and practical questions. The third part of this review will be dedicated to invasive neuromodulation strategies, such as vagus nerve stimulation (VNS) and deep brain stimulation (DBS). In combination with neuroimaging approaches, these techniques are promising experimental tools to unravel the intricate relationships between homeostatic and hedonic brain circuits. Their potential as additional therapeutic tools to combat pharmacorefractory morbid obesity or acute eating disorders will be discussed, in terms of technical challenges, applicability and ethics. In a general discussion, we will put the brain at the core of fundamental research, prevention and therapy in the context of obesity and eating disorders. First, we will discuss the possibility to identify new biological markers of brain functions. Second, we will highlight the potential of neuroimaging and neuromodulation in individualized medicine. Third, we will introduce the ethical questions that are concomitant to the emergence of new neuromodulation therapies. |
Author | Alonso-Alonso, M. Malbert, C.H. Quaresima, V. Stoeckel, L.E. Audette, M. Ferrari, M. Aarts, E. Stice, E. Weber, B. Val-Laillet, D. |
AuthorAffiliation | i Oregon Research Institute, USA e Massachusetts General Hospital, Harvard Medical School, USA f Beth Israel Deaconess Medical Center, Harvard Medical School, USA d Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy b Radboud University, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands h INRA, US1395 Ani-Scans, France c Department of Epileptology, University Hospital Bonn, Germany g Old Dominion University, USA a INRA, UR1341 ADNC, France |
AuthorAffiliation_xml | – name: a INRA, UR1341 ADNC, France – name: i Oregon Research Institute, USA – name: c Department of Epileptology, University Hospital Bonn, Germany – name: g Old Dominion University, USA – name: d Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy – name: e Massachusetts General Hospital, Harvard Medical School, USA – name: f Beth Israel Deaconess Medical Center, Harvard Medical School, USA – name: b Radboud University, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands – name: h INRA, US1395 Ani-Scans, France |
Author_xml | – sequence: 1 givenname: D. surname: Val-Laillet fullname: Val-Laillet, D. email: david.val-laillet@rennes.inra.fr organization: INRA, UR1341 ADNC, France – sequence: 2 givenname: E. surname: Aarts fullname: Aarts, E. organization: Radboud University, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands – sequence: 3 givenname: B. surname: Weber fullname: Weber, B. organization: Department of Epileptology, University Hospital Bonn, Germany – sequence: 4 givenname: M. surname: Ferrari fullname: Ferrari, M. organization: Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy – sequence: 5 givenname: V. surname: Quaresima fullname: Quaresima, V. organization: Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy – sequence: 6 givenname: L.E. surname: Stoeckel fullname: Stoeckel, L.E. organization: Massachusetts General Hospital, Harvard Medical School, USA – sequence: 7 givenname: M. surname: Alonso-Alonso fullname: Alonso-Alonso, M. organization: Beth Israel Deaconess Medical Center, Harvard Medical School, USA – sequence: 8 givenname: M. orcidid: 0000-0003-0011-1731 surname: Audette fullname: Audette, M. organization: Old Dominion University, USA – sequence: 9 givenname: C.H. orcidid: 0000-0002-0665-4545 surname: Malbert fullname: Malbert, C.H. organization: INRA, US1395 Ani-Scans, France – sequence: 10 givenname: E. surname: Stice fullname: Stice, E. organization: Oregon Research Institute, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26110109$$D View this record in MEDLINE/PubMed https://hal.science/hal-01417725$$DView record in HAL |
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Keywords | aCC Brain HFD TRD HD-tDCS PFC STN Neuromodulation lPFC DBS tRNS DBT BOLD VNS ED VBM Human rCBF Obesity EEG vlPFC AN fMRI daCC dlPFC DTI dTMS VN O2Hb MER 5-HT VS Neuroimaging ADHD VTA LHA CBF ANT vmPFC tACS OFC SPECT MRS BS pCC Cg25 BMI BED fNIRS HHb Eating disorders GP CCK B N vmH Nac OCD PYY PD BAT tDCS DAT rtfMRI TMS DA rTMS PET Parkinson's disease attention deficit hyperactivity disorder magnetic resonance spectroscopy eating disorders transcranial magnetic stimulation serotonin O 2Hb transcranial random noise stimulation orbitofrontal cortex transcranial alternate current stimulation anterior cingulate cortex bulimia nervosa subgenual cingulate cortex blood oxygenation level dependent treatment-resistant depression cerebral blood flow cholecystokinin deoxygenated-hemoglobin obsessive–compulsive disorder dorsal anterior cingulate cortex vagus nerve binge eating disorder deep brain therapy ventromedial hypothalamus vagus nerve stimulation lateral prefrontal cortex dopamine transporter brown adipose tissue ventromedial prefrontal cortex regional cerebral blood flow dopamine ventral striatum peptide tyrosine tyrosine anterior nucleus of the thalamus dorsolateral prefrontal cortex transcranial direct current stimulation ventrolateral prefrontal cortex globus pallidus repetitive transcranial magnetic stimulation body mass index single photon emission computed tomography nucleus accumbens deep brain stimulation ventral tegmental area functional near-infrared spectroscopy subthalamic nucleus high-fat diet diffusion tensor imaging functional magnetic resonance imaging prefrontal cortex lateral hypothalamus anorexia nervosa oxygenated-hemoglobin posterior cingulate cortex electroencephalography microelectrode recording bariatric surgery deep transcranial magnetic stimulation voxel-based morphometry real-time functional magnetic resonance imaging high-definition transcranial direct current stimulation positron emission tomography VN, vagus nerve DBS, deep brain stimulation VS, ventral striatum rtfMRI, real-time functional magnetic resonance imaging tDCS, transcranial direct current stimulation TMS, transcranial magnetic stimulation STN, subthalamic nucleus VBM, voxel-based morphometry BMI, body mass index BED, binge eating disorder GP, globus pallidus tACS, transcranial alternate current stimulation MRS, magnetic resonance spectroscopy pCC, posterior cingulate cortex HD-tDCS, high-definition transcranial direct current stimulation DA, dopamine DAT, dopamine transporter PET, positron emission tomography HHb, deoxygenated-hemoglobin OFC, orbitofrontal cortex SPECT, single photon emission computed tomography CCK, cholecystokinin fMRI, functional magnetic resonance imaging tRNS, transcranial random noise stimulation CBF, cerebral blood flow B N, bulimia nervosa EEG, electroencephalography PD, Parkinson's disease BOLD, blood oxygenation level dependent ANT, anterior nucleus of the thalamus TRD, treatment-resistant depression dlPFC, dorsolateral prefrontal cortex ED, eating disorders VNS, vagus nerve stimulation OCD, obsessive–compulsive disorder PFC, prefrontal cortex Nac, nucleus accumbens ADHD, attention deficit hyperactivity disorder Cg25, subgenual cingulate cortex LHA, lateral hypothalamus VTA, ventral tegmental area fNIRS, functional near-infrared spectroscopy aCC, anterior cingulate cortex HFD, high-fat diet 5-HT, serotonin dTMS, deep transcranial magnetic stimulation rCBF, regional cerebral blood flow O2Hb, oxygenated-hemoglobin lPFC, lateral prefrontal cortex BS, bariatric surgery AN, anorexia nervosa BAT, brown adipose tissue vmH, ventromedial hypothalamus DBT, deep brain therapy PYY, peptide tyrosine tyrosine daCC, dorsal anterior cingulate cortex MER, microelectrode recording vlPFC, ventrolateral prefrontal cortex vmPFC, ventromedial prefrontal cortex DTI, diffusion tensor imaging rTMS, repetitive transcranial magnetic stimulation comportement alimentaire trouble alimentaire human health hyperphagia homme cerveau imagerie cerebrale obésité fonction cérébrale santé humaine food habits human |
Language | English |
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Snippet | Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating... AbstractFunctional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and... |
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SubjectTerms | Brain Brain - physiopathology Eating disorders Electric Stimulation Therapy - methods Electroencephalography - methods Feeding and Eating Disorders - physiopathology Feeding and Eating Disorders - prevention & control Feeding and Eating Disorders - therapy Feeding Behavior - physiology Human Humans Life Sciences Neurofeedback - methods Neuroimaging Neuroimaging - methods Neuromodulation Obesity Obesity - physiopathology Obesity - prevention & control Obesity - therapy Radiology Review Transcranial Magnetic Stimulation - methods |
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Title | Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity |
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