RB1-deficient prostate tumor growth and metastasis are vulnerable to ferroptosis induction via the E2F/ACSL4 axis

• Published in: The Journal of clinical investigation Vol. 133; no. 10; pp. 1 - 12
• Main Authors: Wang, Mu-En, Chen, Jiaqi, Lu, Yi, Bawcom, Alyssa R., Wu, Jinjin, Ou, Jianhong, Asara, John M., Armstrong, Andrew J., Wang, Qianben, Li, Lei, Wang, Yuzhuo, Huang, Jiaoti, Chen, Ming
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 15.05.2023
• Subjects: Acetyl coenzyme A synthetase; Androgens; Animals; Apoptosis; Arachidonic acid; Biomedical research; Cancer therapies; Castration; Cell activation; Cell cycle; Cell death; Cell Line; Coenzyme A Ligases - genetics; Coenzyme A Ligases - metabolism; Development and progression; E2F protein; Ferroptosis; Ferroptosis - genetics; Genes; Genetic aspects; Genetic engineering; Health aspects; Humans; Kinases; Lipid peroxidation; Lipids; Male; Malignancy; Metastases; Metastasis; Mice; Oncology; Phospholipids; Physiological aspects; Prostate cancer; Prostatic Neoplasms - pathology; Retinoblastoma; Retinoblastoma Binding Proteins - genetics; Retinoblastoma Binding Proteins - metabolism; Transcription factors; Tumor suppressor genes; Tumors; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; United States; Oncology; Prostate cancer

Inactivation of the RB1 tumor suppressor gene is common in several types of therapy-resistant cancers, including metastatic castration-resistant prostate cancer, and predicts poor clinical outcomes. Effective therapeutic strategies against RB1-deficient cancers remain elusive. Here, we showed that R...