RB1-deficient prostate tumor growth and metastasis are vulnerable to ferroptosis induction via the E2F/ACSL4 axis - Wang, Mu-En; Chen, Jiaqi; Lu, Yi; Bawcom, Alyssa R.; Wu, Jinjin; Ou, Jianhong; Asara, John M.; Armstrong, Andrew J.; Wang, Qianben; Li, Lei; Wang, Yuzhuo; Huang, Jiaoti; et al. (The Journal of clinical investigation, 2023)
Keywords: Acetyl coenzyme A synthetase; Androgens; Animals; Apoptosis; Arachidonic acid; Biomedical research; Cancer therapies; Castration; Cell activation; Cell cycle; Cell death; Cell Line; Coenzyme A Ligases - genetics; Coenzyme A Ligases - metabolism; Development and progression; E2F protein; Ferroptosis; Ferroptosis - genetics; Genes; Genetic aspects; Genetic engineering; Health aspects; Humans; Kinases; Lipid peroxidation; Lipids; Male; Malignancy; Metastases; Metastasis; Mice; Oncology; Phospholipids; Physiological aspects; Prostate cancer; Prostatic Neoplasms - pathology; Retinoblastoma; Retinoblastoma Binding Proteins - genetics; Retinoblastoma Binding Proteins - metabolism; Transcription factors; Tumor suppressor genes; Tumors; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; United States; Oncology; Prostate cancer