Potential metabolic resistance mechanisms to ivermectin in Anopheles gambiae: a synergist bioassay study
Background Despite remarkable success obtained with current malaria vector control strategies in the last 15 years, additional innovative measures will be needed to achieve the ambitious goals for malaria control set for 2030 by the World Health Organization (WHO). New tools will need to address ins...
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| Published in | Parasites & vectors Vol. 14; no. 1; p. 172 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
BioMed Central
20.03.2021
BioMed Central Ltd BMC |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1756-3305 1756-3305 |
| DOI | 10.1186/s13071-021-04675-9 |
Cover
| Abstract | Background
Despite remarkable success obtained with current malaria vector control strategies in the last 15 years, additional innovative measures will be needed to achieve the ambitious goals for malaria control set for 2030 by the World Health Organization (WHO). New tools will need to address insecticide resistance and residual transmission as key challenges. Endectocides such as ivermectin are drugs that kill mosquitoes which feed on treated subjects. Mass administration of ivermectin can effectively target outdoor and early biting vectors, complementing the still effective conventional tools. Although this approach has garnered attention, development of ivermectin resistance is a potential pitfall. Herein, we evaluate the potential role of xenobiotic pumps and cytochrome P450 enzymes in protecting mosquitoes against ivermectin by active efflux and metabolic detoxification, respectively.
Methods
We determined the lethal concentration 50 for ivermectin in colonized
Anopheles gambiae
; then we used chemical inhibitors and inducers of xenobiotic pumps and cytochrome P450 enzymes in combination with ivermectin to probe the mechanism of ivermectin detoxification.
Results
Dual inhibition of xenobiotic pumps and cytochromes was found to have a synergistic effect with ivermectin, greatly increasing mosquito mortality. Inhibition of xenobiotic pumps alone had no effect on ivermectin-induced mortality. Induction of xenobiotic pumps and cytochromes may confer partial protection from ivermectin.
Conclusion
There is a clear pathway for development of ivermectin resistance in malaria vectors. Detoxification mechanisms mediated by cytochrome P450 enzymes are more important than xenobiotic pumps in protecting mosquitoes against ivermectin.
Graphical Abstract |
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| AbstractList | BACKGROUND: Despite remarkable success obtained with current malaria vector control strategies in the last 15 years, additional innovative measures will be needed to achieve the ambitious goals for malaria control set for 2030 by the World Health Organization (WHO). New tools will need to address insecticide resistance and residual transmission as key challenges. Endectocides such as ivermectin are drugs that kill mosquitoes which feed on treated subjects. Mass administration of ivermectin can effectively target outdoor and early biting vectors, complementing the still effective conventional tools. Although this approach has garnered attention, development of ivermectin resistance is a potential pitfall. Herein, we evaluate the potential role of xenobiotic pumps and cytochrome P450 enzymes in protecting mosquitoes against ivermectin by active efflux and metabolic detoxification, respectively. METHODS: We determined the lethal concentration 50 for ivermectin in colonized Anopheles gambiae; then we used chemical inhibitors and inducers of xenobiotic pumps and cytochrome P450 enzymes in combination with ivermectin to probe the mechanism of ivermectin detoxification. RESULTS: Dual inhibition of xenobiotic pumps and cytochromes was found to have a synergistic effect with ivermectin, greatly increasing mosquito mortality. Inhibition of xenobiotic pumps alone had no effect on ivermectin-induced mortality. Induction of xenobiotic pumps and cytochromes may confer partial protection from ivermectin. CONCLUSION: There is a clear pathway for development of ivermectin resistance in malaria vectors. Detoxification mechanisms mediated by cytochrome P450 enzymes are more important than xenobiotic pumps in protecting mosquitoes against ivermectin. Despite remarkable success obtained with current malaria vector control strategies in the last 15 years, additional innovative measures will be needed to achieve the ambitious goals for malaria control set for 2030 by the World Health Organization (WHO). New tools will need to address insecticide resistance and residual transmission as key challenges. Endectocides such as ivermectin are drugs that kill mosquitoes which feed on treated subjects. Mass administration of ivermectin can effectively target outdoor and early biting vectors, complementing the still effective conventional tools. Although this approach has garnered attention, development of ivermectin resistance is a potential pitfall. Herein, we evaluate the potential role of xenobiotic pumps and cytochrome P450 enzymes in protecting mosquitoes against ivermectin by active efflux and metabolic detoxification, respectively. We determined the lethal concentration 50 for ivermectin in colonized Anopheles gambiae; then we used chemical inhibitors and inducers of xenobiotic pumps and cytochrome P450 enzymes in combination with ivermectin to probe the mechanism of ivermectin detoxification. Dual inhibition of xenobiotic pumps and cytochromes was found to have a synergistic effect with ivermectin, greatly increasing mosquito mortality. Inhibition of xenobiotic pumps alone had no effect on ivermectin-induced mortality. Induction of xenobiotic pumps and cytochromes may confer partial protection from ivermectin. There is a clear pathway for development of ivermectin resistance in malaria vectors. Detoxification mechanisms mediated by cytochrome P450 enzymes are more important than xenobiotic pumps in protecting mosquitoes against ivermectin. Despite remarkable success obtained with current malaria vector control strategies in the last 15 years, additional innovative measures will be needed to achieve the ambitious goals for malaria control set for 2030 by the World Health Organization (WHO). New tools will need to address insecticide resistance and residual transmission as key challenges. Endectocides such as ivermectin are drugs that kill mosquitoes which feed on treated subjects. Mass administration of ivermectin can effectively target outdoor and early biting vectors, complementing the still effective conventional tools. Although this approach has garnered attention, development of ivermectin resistance is a potential pitfall. Herein, we evaluate the potential role of xenobiotic pumps and cytochrome P450 enzymes in protecting mosquitoes against ivermectin by active efflux and metabolic detoxification, respectively. We determined the lethal concentration 50 for ivermectin in colonized Anopheles gambiae; then we used chemical inhibitors and inducers of xenobiotic pumps and cytochrome P450 enzymes in combination with ivermectin to probe the mechanism of ivermectin detoxification. Dual inhibition of xenobiotic pumps and cytochromes was found to have a synergistic effect with ivermectin, greatly increasing mosquito mortality. Inhibition of xenobiotic pumps alone had no effect on ivermectin-induced mortality. Induction of xenobiotic pumps and cytochromes may confer partial protection from ivermectin. There is a clear pathway for development of ivermectin resistance in malaria vectors. Detoxification mechanisms mediated by cytochrome P450 enzymes are more important than xenobiotic pumps in protecting mosquitoes against ivermectin. Background Despite remarkable success obtained with current malaria vector control strategies in the last 15 years, additional innovative measures will be needed to achieve the ambitious goals for malaria control set for 2030 by the World Health Organization (WHO). New tools will need to address insecticide resistance and residual transmission as key challenges. Endectocides such as ivermectin are drugs that kill mosquitoes which feed on treated subjects. Mass administration of ivermectin can effectively target outdoor and early biting vectors, complementing the still effective conventional tools. Although this approach has garnered attention, development of ivermectin resistance is a potential pitfall. Herein, we evaluate the potential role of xenobiotic pumps and cytochrome P450 enzymes in protecting mosquitoes against ivermectin by active efflux and metabolic detoxification, respectively. Methods We determined the lethal concentration 50 for ivermectin in colonized Anopheles gambiae ; then we used chemical inhibitors and inducers of xenobiotic pumps and cytochrome P450 enzymes in combination with ivermectin to probe the mechanism of ivermectin detoxification. Results Dual inhibition of xenobiotic pumps and cytochromes was found to have a synergistic effect with ivermectin, greatly increasing mosquito mortality. Inhibition of xenobiotic pumps alone had no effect on ivermectin-induced mortality. Induction of xenobiotic pumps and cytochromes may confer partial protection from ivermectin. Conclusion There is a clear pathway for development of ivermectin resistance in malaria vectors. Detoxification mechanisms mediated by cytochrome P450 enzymes are more important than xenobiotic pumps in protecting mosquitoes against ivermectin. Graphical Abstract Despite remarkable success obtained with current malaria vector control strategies in the last 15 years, additional innovative measures will be needed to achieve the ambitious goals for malaria control set for 2030 by the World Health Organization (WHO). New tools will need to address insecticide resistance and residual transmission as key challenges. Endectocides such as ivermectin are drugs that kill mosquitoes which feed on treated subjects. Mass administration of ivermectin can effectively target outdoor and early biting vectors, complementing the still effective conventional tools. Although this approach has garnered attention, development of ivermectin resistance is a potential pitfall. Herein, we evaluate the potential role of xenobiotic pumps and cytochrome P450 enzymes in protecting mosquitoes against ivermectin by active efflux and metabolic detoxification, respectively.BACKGROUNDDespite remarkable success obtained with current malaria vector control strategies in the last 15 years, additional innovative measures will be needed to achieve the ambitious goals for malaria control set for 2030 by the World Health Organization (WHO). New tools will need to address insecticide resistance and residual transmission as key challenges. Endectocides such as ivermectin are drugs that kill mosquitoes which feed on treated subjects. Mass administration of ivermectin can effectively target outdoor and early biting vectors, complementing the still effective conventional tools. Although this approach has garnered attention, development of ivermectin resistance is a potential pitfall. Herein, we evaluate the potential role of xenobiotic pumps and cytochrome P450 enzymes in protecting mosquitoes against ivermectin by active efflux and metabolic detoxification, respectively.We determined the lethal concentration 50 for ivermectin in colonized Anopheles gambiae; then we used chemical inhibitors and inducers of xenobiotic pumps and cytochrome P450 enzymes in combination with ivermectin to probe the mechanism of ivermectin detoxification.METHODSWe determined the lethal concentration 50 for ivermectin in colonized Anopheles gambiae; then we used chemical inhibitors and inducers of xenobiotic pumps and cytochrome P450 enzymes in combination with ivermectin to probe the mechanism of ivermectin detoxification.Dual inhibition of xenobiotic pumps and cytochromes was found to have a synergistic effect with ivermectin, greatly increasing mosquito mortality. Inhibition of xenobiotic pumps alone had no effect on ivermectin-induced mortality. Induction of xenobiotic pumps and cytochromes may confer partial protection from ivermectin.RESULTSDual inhibition of xenobiotic pumps and cytochromes was found to have a synergistic effect with ivermectin, greatly increasing mosquito mortality. Inhibition of xenobiotic pumps alone had no effect on ivermectin-induced mortality. Induction of xenobiotic pumps and cytochromes may confer partial protection from ivermectin.There is a clear pathway for development of ivermectin resistance in malaria vectors. Detoxification mechanisms mediated by cytochrome P450 enzymes are more important than xenobiotic pumps in protecting mosquitoes against ivermectin.CONCLUSIONThere is a clear pathway for development of ivermectin resistance in malaria vectors. Detoxification mechanisms mediated by cytochrome P450 enzymes are more important than xenobiotic pumps in protecting mosquitoes against ivermectin. Background Despite remarkable success obtained with current malaria vector control strategies in the last 15 years, additional innovative measures will be needed to achieve the ambitious goals for malaria control set for 2030 by the World Health Organization (WHO). New tools will need to address insecticide resistance and residual transmission as key challenges. Endectocides such as ivermectin are drugs that kill mosquitoes which feed on treated subjects. Mass administration of ivermectin can effectively target outdoor and early biting vectors, complementing the still effective conventional tools. Although this approach has garnered attention, development of ivermectin resistance is a potential pitfall. Herein, we evaluate the potential role of xenobiotic pumps and cytochrome P450 enzymes in protecting mosquitoes against ivermectin by active efflux and metabolic detoxification, respectively. Methods We determined the lethal concentration 50 for ivermectin in colonized Anopheles gambiae; then we used chemical inhibitors and inducers of xenobiotic pumps and cytochrome P450 enzymes in combination with ivermectin to probe the mechanism of ivermectin detoxification. Results Dual inhibition of xenobiotic pumps and cytochromes was found to have a synergistic effect with ivermectin, greatly increasing mosquito mortality. Inhibition of xenobiotic pumps alone had no effect on ivermectin-induced mortality. Induction of xenobiotic pumps and cytochromes may confer partial protection from ivermectin. Conclusion There is a clear pathway for development of ivermectin resistance in malaria vectors. Detoxification mechanisms mediated by cytochrome P450 enzymes are more important than xenobiotic pumps in protecting mosquitoes against ivermectin. Keywords: Ivermectin, Endectocide, Resistance, Insecticide resistance, CYP, P-gp, ABC transporter, Synergists, Bioassay Abstract Background Despite remarkable success obtained with current malaria vector control strategies in the last 15 years, additional innovative measures will be needed to achieve the ambitious goals for malaria control set for 2030 by the World Health Organization (WHO). New tools will need to address insecticide resistance and residual transmission as key challenges. Endectocides such as ivermectin are drugs that kill mosquitoes which feed on treated subjects. Mass administration of ivermectin can effectively target outdoor and early biting vectors, complementing the still effective conventional tools. Although this approach has garnered attention, development of ivermectin resistance is a potential pitfall. Herein, we evaluate the potential role of xenobiotic pumps and cytochrome P450 enzymes in protecting mosquitoes against ivermectin by active efflux and metabolic detoxification, respectively. Methods We determined the lethal concentration 50 for ivermectin in colonized Anopheles gambiae; then we used chemical inhibitors and inducers of xenobiotic pumps and cytochrome P450 enzymes in combination with ivermectin to probe the mechanism of ivermectin detoxification. Results Dual inhibition of xenobiotic pumps and cytochromes was found to have a synergistic effect with ivermectin, greatly increasing mosquito mortality. Inhibition of xenobiotic pumps alone had no effect on ivermectin-induced mortality. Induction of xenobiotic pumps and cytochromes may confer partial protection from ivermectin. Conclusion There is a clear pathway for development of ivermectin resistance in malaria vectors. Detoxification mechanisms mediated by cytochrome P450 enzymes are more important than xenobiotic pumps in protecting mosquitoes against ivermectin. |
| ArticleNumber | 172 |
| Audience | Academic |
| Author | Nicolas, Patricia Maia, Marta Chaccour, Carlos Wagah, Martin G. Muturi, Martha Hammann, Felix Duthaler, Urs Kiuru, Caroline |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33743783$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1186/s12936-016-1540-y 10.1016/j.ijpara.2011.08.004 10.1186/s13071-018-2823-7 10.1186/s12936-019-2988-3 10.1073/pnas.1610992113 10.1146/annurev-ento-010814-020828 10.1016/S1473-3099(18)30163-4 10.1093/ije/28.2.319 10.2165/00003088-199835040-00002 10.1001/jama.1919.26110150003011c 10.1111/j.1752-4571.2009.00072.x 10.1186/s13071-020-04170-7 10.1007/s40122-017-0070-9 10.1186/1475-2875-11-381 10.1038/srep01300 10.2165/00003088-200342090-00003 10.1186/s12936-017-1801-4 10.4269/ajtmh.19-0620 10.1086/653208 10.1603/ME11164 10.1186/1475-2875-12-13 10.1093/cid/ciu797 10.1002/cpt.1716 10.1093/jac/dkw032 10.1016/j.pt.2015.11.010 10.1371/journal.pntd.0003507 10.1093/biomet/91.2.263 10.1158/1078-0432.CCR-06-2414 10.1186/s13071-017-2563-0 10.2174/138920112800399248 10.1124/dmd.105.008615 10.1080/004982598239597 10.1186/1475-2875-13-417 10.1111/imb.12351 10.1016/j.actatropica.2010.06.001 10.1002/ieam.96 10.1038/s41598-018-30907-7 10.1016/j.ibmb.2004.03.018 10.1179/000349809X12459740922138 10.1177/1060028017717018 10.2147/HIV.S70836 10.1016/j.ibmb.2013.11.001 10.1371/journal.pntd.0000270 10.1186/1475-2875-10-80 10.1186/s12936-018-2296-3 10.1111/imb.12204 10.1046/j.1365-2915.2002.00365.x 10.1080/14787210.2017.1271713 10.1016/j.ijantimicag.2018.07.005 |
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| Keywords | Resistance Endectocide Insecticide resistance P-gp Bioassay CYP ABC transporter Ivermectin Synergists |
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| References | JI Blanford (4675_CR26) 2013; 3 KC Kobylinski (4675_CR47) 2020; 107 X Wang (4675_CR57) 2016 Z Zeng (4675_CR39) 1998 4675_CR49 PJ Hotez (4675_CR12) 2008 KC Kobylinski (4675_CR27) 2010 W Mekuriaw (4675_CR17) 2019; 18 C Chaccour (4675_CR14) 2017 PC Pohl (4675_CR24) 2011 N Liu (4675_CR22) 2015; 60 4675_CR34 S Sougoufara (4675_CR7) 2020 4675_CR32 4675_CR31 M Niemi (4675_CR38) 2003 J Rautio (4675_CR37) 2006 C Chaccour (4675_CR11) 2010 VDS Sampaio (4675_CR48) 2017 VL Le Gall (4675_CR25) 2018 4675_CR36 H Alout (4675_CR10) 2014 WHO (4675_CR55) 2017 A Hsu (4675_CR35) 1998; 35 A Tseng (4675_CR51) 2017 M Liebig (4675_CR54) 2010 J Hemingway (4675_CR58) 2004 DJ Siria (4675_CR41) 2018; 11 KM Deus (4675_CR43) 2012 JC Koella (4675_CR53) 2009 RE Gangnon (4675_CR30) 2004; 91 J Lawrence (4675_CR19) 2015; 9 H Alout (4675_CR56) 2017; 15 C Bass (4675_CR15) 2016; 113 N Amanzougaghene (4675_CR18) 2018; 52 DS Buss (4675_CR23) 2002 VS Sampaio (4675_CR16) 2016; 15 P Gonzalez (4675_CR13) 2012 MR Smit (4675_CR46) 2018; 18 RJ Hayes (4675_CR28) 1999; 28 FHK Reynolds (4675_CR40) 1919 ML Fritz (4675_CR44) 2009 C Marzolini (4675_CR50) 2016 IELM Kuppens (4675_CR33) 2007; 13 KC Kobylinski (4675_CR45) 2012 W Dermauw (4675_CR20) 2014 N von Hentig (4675_CR52) 2015 AL Ouédraogo (4675_CR29) 2015; 60 SM Dreyer (4675_CR42) 2018 H Ranson (4675_CR6) 2016 P Pignatelli (4675_CR21) 2018; 27 4675_CR8 4675_CR5 P Billingsley (4675_CR9) 2020 4675_CR4 4675_CR3 4675_CR2 4675_CR1 |
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Parasitol doi: 10.1179/000349809X12459740922138 – ident: 4675_CR1 – year: 2017 ident: 4675_CR51 publication-title: Ann Pharmacother doi: 10.1177/1060028017717018 – year: 2015 ident: 4675_CR52 publication-title: HIV/AIDS Res Palliative Care doi: 10.2147/HIV.S70836 – year: 2014 ident: 4675_CR20 publication-title: Insect Biochem Mol Biol doi: 10.1016/j.ibmb.2013.11.001 – year: 2008 ident: 4675_CR12 publication-title: PLoS Negl Trop Dis doi: 10.1371/journal.pntd.0000270 – ident: 4675_CR5 doi: 10.1186/1475-2875-10-80 – year: 2018 ident: 4675_CR42 publication-title: Malar J doi: 10.1186/s12936-018-2296-3 – year: 2016 ident: 4675_CR57 publication-title: Insect Mol Biol doi: 10.1111/imb.12204 – ident: 4675_CR34 – year: 2002 ident: 4675_CR23 publication-title: Med Vet Entomol doi: 10.1046/j.1365-2915.2002.00365.x – volume: 15 start-page: 231 year: 2017 ident: 4675_CR56 publication-title: Expert Rev Anti Infect Ther doi: 10.1080/14787210.2017.1271713 – volume: 52 start-page: 593 year: 2018 ident: 4675_CR18 publication-title: Int J Antimicrob Agents doi: 10.1016/j.ijantimicag.2018.07.005 |
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Despite remarkable success obtained with current malaria vector control strategies in the last 15 years, additional innovative measures will be... Despite remarkable success obtained with current malaria vector control strategies in the last 15 years, additional innovative measures will be needed to... Despite remarkable success obtained with current malaria vector control strategies in the last 15 years, additional innovative measures will be needed to... Background Despite remarkable success obtained with current malaria vector control strategies in the last 15 years, additional innovative measures will be... BACKGROUND: Despite remarkable success obtained with current malaria vector control strategies in the last 15 years, additional innovative measures will be... Abstract Background Despite remarkable success obtained with current malaria vector control strategies in the last 15 years, additional innovative measures... |
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| Title | Potential metabolic resistance mechanisms to ivermectin in Anopheles gambiae: a synergist bioassay study |
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