Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells - Palrasu, Manikandan; Zaika, Elena; El-Rifai, Wael; Garcia-Buitrago, Monica; Piazuelo, Maria Blanca; Wilson, Keith T.; Peek, Richard M.; Zaika, Alexander I. (The Journal of clinical investigation, 2020)
Keywords: 1-Phosphatidylinositol 3-kinase; AKT protein; Analysis; Antigens, Bacterial - genetics; Antigens, Bacterial - metabolism; Apoptosis; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; Bacteria; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Binding sites; Biodegradation; Biomedical research; CagA protein; Cancer; Cells (Biology); Deoxyribonucleic acid; Development and progression; DNA; DNA damage; Epithelial cells; Epithelial Cells - metabolism; Epithelial Cells - microbiology; Epithelial Cells - pathology; Experiments; Gastric cancer; Gastric Mucosa - metabolism; Gastric Mucosa - microbiology; Gastric Mucosa - pathology; Gastrointestinal diseases; Genetic aspects; HCT116 Cells; Health aspects; Helicobacter infections; Helicobacter pylori; Helicobacter pylori - genetics; Helicobacter pylori - metabolism; Homeostasis; Humans; Infection; Infections; Kinases; Ligases; Medical equipment industry; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Phosphorylation; Proteasomes; Proteins; Proteolysis; Risk factors; Stomach cancer; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Studies; Tumor suppressor genes; Tumorigenesis; Tumors; Ubiquitin; Ubiquitin-protein ligase; Ubiquitination; Virulence (Microbiology); Virulence factors; X-Linked Inhibitor of Apoptosis Protein - genetics; X-Linked Inhibitor of Apoptosis Protein - metabolism; XIAP protein; Florida; United States; Gastric cancer; Gastroenterology