Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

• Published in: Nature cell biology Vol. 16; no. 4; pp. 367 - 375
• Main Authors: Chau, You-Ying, Bandiera, Roberto, Serrels, Alan, Martínez-Estrada, Ofelia M., Qing, Wei, Lee, Martin, Slight, Joan, Thornburn, Anna, Berry, Rachel, McHaffie, Sophie, Stimson, Roland H., Walker, Brian R., Chapuli, Ramon Muñoz, Schedl, Andreas, Hastie, Nick
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2014; Nature Publishing Group
• Subjects: 631/136/142; 631/136/334/1874; 631/136/532/2074; Adipocytes; Adipocytes - cytology; Adipocytes - metabolism; Adipose tissue; Adipose Tissue, Brown - cytology; Adipose Tissue, Brown - embryology; Adipose Tissue, Brown - metabolism; Adipose Tissue, White - cytology; Adipose Tissue, White - embryology; Adipose Tissue, White - metabolism; Adipose tissues; Animals; Antineoplastic Agents, Hormonal - pharmacology; Biology; Body fat; Cancer Research; Cell Biology; Cell Lineage - genetics; Cell research; Cellular control mechanisms; Development Biology; Developmental Biology; Epidemics; Gene Knock-In Techniques; Genetics; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; letter; Life Sciences; Lipid metabolism; Medical research; Mesoderm - cytology; Mesoderm - metabolism; Metabolisme dels lípids; Mice; Obesity; Physiological aspects; Stem Cells; Tamoxifen - pharmacology; Teixit adipós; WT1 Proteins - genetics; WT1 Proteins - metabolism; United Kingdom > UK; Spain

Increased visceral adipose tissue has been associated with metabolic dysfunction but the origin of the progenitors that give rise to this tissue, and whether they are the same as the progenitors contributing to the protective subcutaneous adipose tissue, was unclear. Hastie and colleagues have found...