Mouse models of neutropenia reveal progenitor-stage-specific defects

• Published in: Nature (London) Vol. 582; no. 7810; pp. 109 - 114
• Main Authors: Muench, David E., Olsson, Andre, Ferchen, Kyle, Pham, Giang, Serafin, Rachel A., Chutipongtanate, Somchai, Dwivedi, Pankaj, Song, Baobao, Hay, Stuart, Chetal, Kashish, Trump-Durbin, Lisa R., Mookerjee-Basu, Jayati, Zhang, Kejian, Yu, Jennifer C., Lutzko, Carolyn, Myers, Kasiani C., Nazor, Kristopher L., Greis, Kenneth D., Kappes, Dietmar J., Way, Sing Sing, Salomonis, Nathan, Grimes, H. Leighton
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2020; Nature Publishing Group
• Subjects: 13; 13/100; 13/31; 38; 38/1; 38/35; 45; 45/23; 45/91; 631/136/1425; 631/208/199; 631/250/232/2059; 64; 64/60; 692/699/1541; 82; 82/81; 96; 96/21; Animal models; Animal models in research; Animals; Candida albicans - immunology; Candida albicans - pathogenicity; Cell cycle; Cell differentiation; Cell Lineage; Defects; Disease Models, Animal; DNA-Binding Proteins - genetics; Female; Gene expression; Genes; Genetic aspects; Genetics; Genomics; Granulocyte Precursor Cells - pathology; Granulocytes; Health aspects; Humanities and Social Sciences; Humans; Immunity, Innate; Male; Mice; Mice, Transgenic; Molecular modelling; multidisciplinary; Mutants; Mutation; Mutation (Biology); Neutropenia; Neutropenia - congenital; Neutropenia - genetics; Neutropenia - immunology; Neutropenia - pathology; Neutrophils; Neutrophils - immunology; Neutrophils - pathology; Patients; Physiological aspects; Proteins; Science; Science (multidisciplinary); Stem cells; Transcription factors; Transcription Factors - genetics; Transplants & implants; United States

Advances in genetics and sequencing have identified a plethora of disease-associated and disease-causing genetic alterations. To determine causality between genetics and disease, accurate models for molecular dissection are required; however, the rapid expansion of transcriptional populations identi...