Significant decrease of maternal mitochondria carryover using optimized spindle-chromosomal complex transfer

• Published in: PLoS biology Vol. 21; no. 10; p. e3002313
• Main Authors: Liao, Xiaoyu, Li, Wenzhi, Lin, Kaibo, Jin, Wei, Zhang, Shaozhen, Wang, Yao, Ma, Meng, Xie, Yating, Yu, Weina, Yan, Zhiguang, Gao, Hongyuan, Zhao, Leiwen, Si, Jiqiang, Wang, Yun, Lin, Jiaying, Chen, Chen, Chen, Li, Kuang, Yanping, Lyu, Qifeng
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 05.10.2023; Public Library of Science (PLoS)
• Subjects: Animal models; Biocompatibility; Biological research; Biology and life sciences; Biology, Experimental; Blastocysts; Chromosomes; Copy number; Cytoplasm; Disease transmission; Eggs; Embryo cells; Embryogenesis; Embryos; Ethics; Fertilization; Gametocytes; Genetic aspects; Genetic drift; Health services; Hospitals; Medical research; Metaphase; Methods and Resources; Mineral oils; Mitochondria; Mitochondrial DNA; Mutation (Biology); Offspring; Oocytes; Residues; Sperm; Spindle (Cell division); Stem cells; Strategy; China; United States > US

Mutations in mitochondrial DNA (mtDNA) contribute to a variety of serious multi-organ human diseases, which are strictly inherited from the maternal germline. However, there is currently no curative treatment. Attention has been focused on preventing the transmission of mitochondrial diseases throug...