Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney

• Published in: The Journal of clinical investigation Vol. 130; no. 3; pp. 1513 - 1526
• Main Authors: Simic, Petra, Kim, Wondong, Zhou, Wen, Pierce, Kerry A., Chang, Wenhan, Sykes, David B., Aziz, Najihah B., Elmariah, Sammy, Ngo, Debby, Pajevic, Paola Divieti, Govea, Nicolas, Kestenbaum, Bryan R., de Boer, Ian H., Cheng, Zhiqiang, Christov, Marta, Chun, Jerold, Leaf, David E., Waikar, Sushrut S., Tager, Andrew M., Gerszten, Robert E., Thadhani, Ravi I., Clish, Clary B., Jüppner, Harald, Wein, Marc N., Rhee, Eugene P.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.03.2020
• Subjects: Acute Kidney Injury - genetics; Acute Kidney Injury - metabolism; Acute Kidney Injury - pathology; Acyltransferase; Animals; Aptamers; Biomedical research; Bone marrow; Calcitriol; Cell Line; Chromatography; Female; Fibroblast Growth Factor-23; Fibroblast growth factors; Fibroblast Growth Factors - genetics; Fibroblast Growth Factors - metabolism; Fibroblasts; Glycerol; Glycerol-3-phosphate; Glycerophosphates - metabolism; Growth factors; Heart surgery; Homeostasis; Hormones; Human subjects; Humans; Kidney - metabolism; Kidney - pathology; Kidneys; Liquid chromatography; Lysophosphatidic acid; Male; Mass spectrometry; Mass spectroscopy; Metabolites; Metabolomics; Mice; Mice, Knockout; Morbidity; Mortality; Phosphates; Physiological aspects; Proteins; Proteomics; Receptors, Lysophosphatidic Acid - genetics; Receptors, Lysophosphatidic Acid - metabolism; Renal function; Scientific equipment industry; Spectroscopy; Veins & arteries; Vitamin D3; United States; Massachusetts; Bone Biology; Homeostasis; Nephrology; Bone disease; Chronic kidney disease

Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that controls blood phosphate levels by increasing renal phosphate excretion and reducing 1,25-dihydroxyvitamin D3 [1,25(OH)2D] production. Disorders of FGF23 homeostasis are associated with significant morbidity and mortality, but a fund...