Airway epithelium–shifted mast cell infiltration regulates asthmatic inflammation via IL-33 signaling

• Published in: The Journal of clinical investigation Vol. 129; no. 11; pp. 4979 - 4991
• Main Authors: Altman, Matthew C., Lai, Ying, Nolin, James D., Long, Sydney, Chen, Chien-Chang, Piliponsky, Adrian M., Altemeier, William A., Larmore, Megan, Frevert, Charles W., Mulligan, Michael S., Ziegler, Steven F., Debley, Jason S., Peters, Michael C., Hallstrand, Teal S.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.11.2019
• Subjects: Asthma; Asthma - immunology; Asthma - pathology; Biomedical research; Cytokines; Epithelial cells; Epithelium; Female; Genomes; Genotype & phenotype; Histamine; Humans; Inflammation; Inflammation - immunology; Inflammation - pathology; Interleukin-33 - immunology; Male; Mast cells; Mast Cells - immunology; Mast Cells - pathology; Morphometry; Phenotypes; Respiratory Mucosa - immunology; Respiratory Mucosa - pathology; Respiratory tract; Signal Transduction - immunology; Studies; Pulmonology; Mast cells; Immunology; Th2 response; Asthma

Asthma is a heterogeneous syndrome that has been subdivided into physiologic phenotypes and molecular endotypes. The most specific phenotypic manifestation of asthma is indirect airway hyperresponsiveness (AHR), and a prominent molecular endotype is the presence of type 2 inflammation. The underlyin...