Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2 - Shi, Guoli; Chiramel, Abhilash I.; Li, Tiansheng; Lai, Kin Kui; Kenney, Adam D.; Zani, Ashley; Eddy, Adrian C.; Majdoul, Saliha; Zhang, Lizhi; Dempsey, Tirhas; Beare, Paul A.; Kar, Swagata; et al. (The Journal of clinical investigation, 2022)
Keywords: Adaptive immunity; Animal models; Antiviral drugs; Autoimmune diseases; Autoimmunity; Biomedical research; Cancer; Care and treatment; Cell culture; Cell growth; Coronaviruses; COVID-19; Disease transmission; Host-virus relationships; Humans; Immune response; Immunity, Innate; Immunocompromised host; Infections; Influenza; Inhibitor drugs; Kinases; Membrane Proteins; MTOR Inhibitors; Nuclear transport; Phosphorylation; Proteins; Rapamycin; RNA-Binding Proteins; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Sirolimus - pharmacology; Targeted cancer therapy; Testing; Tissue culture; TOR protein; Viral diseases; Viral infections; Virus Internalization; Viruses; United States; COVID-19; Lysosomes; Innate immunity; Autophagy