Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization - Shibata, Takehiko; Makino, Airi; Ogata, Ruiko; Nakamura, Shigeki; Ito, Toshihiro; Nagata, Kisaburo; Terauchi, Yoshihiko; Oishi, Taku; Fujieda, Mikiya; Takahashi, Yoshimasa; Ato, Manabu (The Journal of clinical investigation, 2020)
Keywords: Alveoli; Animals; Antibacterial activity; Antibacterial agents; Axl protein; Bacterial infections; Biomedical research; Caspase-1; Cytokines - genetics; Cytokines - immunology; Disease susceptibility; Genotype & phenotype; Health aspects; Infection; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - immunology; Interleukin 18; Killer cells; Macrophages; Macrophages, Alveolar - immunology; Macrophages, Alveolar - microbiology; Macrophages, Alveolar - pathology; Macrophages, Alveolar - virology; Male; Mice; Mice, Knockout; Natural killer cells; Neutrophils; Phenotypes; Pneumococcal pneumonia; Pneumonia; Pneumonia, Pneumococcal - genetics; Pneumonia, Pneumococcal - immunology; Pneumonia, Pneumococcal - pathology; Pneumonia, Pneumococcal - virology; Protein expression; Proteins; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - immunology; Receptor Protein-Tyrosine Kinases - genetics; Receptor Protein-Tyrosine Kinases - immunology; Respiratory syncytial virus; Respiratory Syncytial Virus Infections - genetics; Respiratory Syncytial Virus Infections - immunology; Respiratory Syncytial Virus Infections - pathology; Respiratory Syncytial Viruses - immunology; Software industry; Streptococcus infections; Therapeutic applications; Tumor necrosis factor-α; Virus diseases; γ-Interferon; United States; Japan; Infectious disease; Innate immunity; Immunology; Cytokines