Evaluation of early-phase [18F]-florbetaben PET acquisition in clinical routine cases

• Published in: NeuroImage clinical Vol. 14; no. C; pp. 77 - 86
• Main Authors: Daerr, Sonja, Brendel, Matthias, Zach, Christian, Mille, Erik, Schilling, Dorothee, Zacherl, Mathias Johannes, Bürger, Katharina, Danek, Adrian, Pogarell, Oliver, Schildan, Andreas, Patt, Marianne, Barthel, Henryk, Sabri, Osama, Bartenstein, Peter, Rominger, Axel
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2017; Elsevier
• Subjects: [18F]-florbetaben PET; Aged; Alzheimer's disease; Amyloidogenic Proteins - metabolism; Aniline Compounds - metabolism; Dementia - diagnostic imaging; Dementia - etiology; FDG Pet; Female; Humans; Imaging, Three-Dimensional - methods; Male; Metabolism; Middle Aged; Neurodegenerative Diseases - complications; Perfusion; Positron-Emission Tomography; Radiology; Regular; Statistics as Topic; Stereotaxic Techniques; Stilbenes - metabolism; Time Factors; ß-amyloid; [18F]-florbetaben PET; CBF; FBB; FDG; GLM; MNI; CBL; L; SPECT; 3D-SSP; R; Alzheimer's disease; FDG Pet; AD; FTLD; p.i; CN; Metabolism; VOI; PCC; MCI; Perfusion; ß-amyloid; SUVR; PET; [ 18F]-florbetaben PET; volume of interest; post injection; cerebellum; posterior cingulate cortex; [ 18F]-fluorodeoxyglucose; standardized uptake value ratio; single photon emission computed tomography; 3-dimensional stereotactic surface projections; right; Montreal Neurological Institute; left; [ 18 F]florbetaben; cerebral blood flow; mild cognitive impairment; cognitively normal; Positron emission tomography; global mean; frontotemporal lobar degeneration; FDG, [18F]-fluorodeoxyglucose; GLM, global mean; MNI, Montreal Neurological Institute; MCI, mild cognitive impairment; FBB, [18F]florbetaben; SUVR, standardized uptake value ratio; p.i., post injection; PCC, posterior cingulate cortex; R, right; VOI, volume of interest; PET, Positron emission tomography; L, left; SPECT, single photon emission computed tomography; CN, cognitively normal; CBF, cerebral blood flow; 3D-SSP, 3-dimensional stereotactic surface projections; CBL, cerebellum; FTLD, frontotemporal lobar degeneration; AD, Alzheimer's disease

In recent years several [18F]-labelled amyloid PET tracers have been developed and have obtained clinical approval. There is accumulating evidence that early (post injection) acquisitions with these tracers are equally informative as conventional blood flow and metabolism studies for diagnosis of Al...