The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children

• Published in: The Journal of clinical investigation Vol. 131; no. 20; pp. 1 - 17
• Main Authors: Porritt, Rebecca A., Binek, Aleksandra, Paschold, Lisa, Rivas, Magali Noval, McArdle, Angela, Yonker, Lael M., Alter, Galit, Chandnani, Harsha K., Lopez, Merrick, Fasano, Alessio, Van Eyk, Jennifer E., Binder, Mascha, Arditi, Moshe
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 15.10.2021
• Subjects: Adaptive Immunity; Adolescent; Antigens; Autoantibodies; Autoimmunity; B-cell receptor; Biomarkers; Biomarkers - metabolism; Biomedical research; Case-Control Studies; Cell activation; Child; Child, Preschool; Children; Cohort Studies; Complement activation; Coronaviruses; COVID-19; COVID-19 - complications; COVID-19 - genetics; COVID-19 - immunology; COVID-19 - metabolism; Cytokine Release Syndrome - immunology; Cytokine storm; Disease; Female; Genetic aspects; Health aspects; Humans; Immune response; Immune response (humoral); Immunoglobulin G; Immunopathogenesis; Infant; Inflammation; Inflammation - immunology; Intensive care; Leukocytes (neutrophilic); Lymphocytes; Lymphocytes T; Male; Mucocutaneous Lymph Node Syndrome - genetics; Mucocutaneous Lymph Node Syndrome - immunology; Mucocutaneous Lymph Node Syndrome - metabolism; Multisystem inflammatory syndrome in children; Neutrophil Activation; Neutrophils; Pandemics; Pathogenesis; Patients; Pediatric research; Pediatrics; Peptides; Plasma; Proteins; Proteomics; Receptors, Antigen, B-Cell - genetics; RNA-Seq; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Systemic Inflammatory Response Syndrome - genetics; Systemic Inflammatory Response Syndrome - immunology; Systemic Inflammatory Response Syndrome - metabolism; T cell receptors; Variable region; United States; COVID-19; Inflammation; Cytokines; Autoimmune diseases; Cellular immune response

Multisystem inflammatory syndrome in children (MIS-C) manifests as a severe and uncontrolled inflammatory response with multiorgan involvement, occurring weeks after SARS-CoV-2 infection. Here, we utilized proteomics, RNA sequencing, autoantibody arrays, and B cell receptor (BCR) repertoire analysis...