IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion

• Published in: The Journal of clinical investigation Vol. 129; no. 8; pp. 3324 - 3338
• Main Authors: Chan, Li-Chuan, Li, Chia-Wei, Xia, Weiya, Hsu, Jung-Mao, Lee, Heng-Huan, Cha, Jong-Ho, Wang, Hung-Ling, Yang, Wen-Hao, Yen, Er-Yen, Chang, Wei-Chao, Zha, Zhengyu, Lim, Seung-Oe, Lai, Yun-Ju, Liu, Chunxiao, Liu, Jielin, Dong, Qiongzhu, Yang, Yi, Sun, Linlin, Wei, Yongkun, Nie, Lei, Hsu, Jennifer L., Li, Hui, Ye, Qinghai, Hassan, Manal M., Amin, Hesham M., Kaseb, Ahmed O., Lin, Xin, Wang, Shao-Chun, Hung, Mien-Chie
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.08.2019
• Subjects: Animal models; Animals; Antibodies; Apoptosis; B7-H1 Antigen - immunology; Biomedical research; Cancer; Carcinoma; Cell activation; Cell growth; Cell Line, Tumor; Chemokines; Cytokines; Endoplasmic reticulum; FDA approval; Federal regulation; Gene expression; Glycosylation; Glycosyltransferase; Growth factors; Hepatocellular carcinoma; Humans; Immune evasion; Immunoglobulins; Immunosuppression; Immunosurveillance; Immunotherapy; Intelligence gathering; Interleukin 6; Interleukin-6 - immunology; Janus kinase; Janus Kinase 1 - immunology; Kinases; Ligands; Liver cancer; Lymphocytes; Lymphocytes T; Male; Medical prognosis; Mice; Mucin; Mutation; Neoplasm Proteins - immunology; Neoplasms, Experimental - immunology; Neoplasms, Experimental - pathology; Neoplasms, Experimental - therapy; Nivolumab; Patients; PD-L1 protein; Phosphorylation; Protein expression; Protein Stability; Proteins; Regorafenib; Response rates; Ruxolitinib; Signal Transduction - immunology; Siltuximab; Sorafenib; T cell receptors; T cells; Tocilizumab; Tumor Escape; Tumors; South Korea; Texas; China; Liver cancer; Oncology; Cancer immunotherapy; Cell Biology

Glycosylation of immune receptors and ligands, such as T cell receptor and coinhibitory molecules, regulates immune signaling activation and immune surveillance. However, how oncogenic signaling initiates glycosylation of coinhibitory molecules to induce immunosuppression remains unclear. Here we sh...