Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

• Published in: The Journal of clinical investigation Vol. 120; no. 3; pp. 694 - 705
• Main Authors: Kioi, Mitomu, Vogel, Hannes, Schultz, Geoffrey, Hoffman, Robert M, Harsh, Griffith R, Brown, J Martin
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.03.2010
• Subjects: Angiogenesis; Animal models in research; Animals; Anti-HIV Agents; Antibodies, Neutralizing; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Biomedical research; Bone Marrow Cells - metabolism; Bone Marrow Cells - pathology; Brain cancer; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; Brain Neoplasms - therapy; Care and treatment; CD11b Antigen - metabolism; Cell Line, Tumor; Cell Movement - drug effects; Cell Movement - radiation effects; Chemokine CXCL12 - antagonists & inhibitors; Chemokine CXCL12 - metabolism; Endothelium; Genetic aspects; Glioblastoma - metabolism; Glioblastoma - pathology; Glioblastoma - therapy; Glioblastoma multiforme; Health aspects; Heterocyclic Compounds - pharmacology; Heterocyclic Compounds - therapeutic use; Humans; Hypotheses; Hypoxia; Hypoxia-Inducible Factor 1 - metabolism; Ischemia; Mice; Mice, Nude; Monocytes - metabolism; Monocytes - pathology; Neoplasm Recurrence, Local - metabolism; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - therapy; Neoplasm Transplantation; Neovascularization; Neovascularization, Pathologic - metabolism; Neovascularization, Pathologic - pathology; Neovascularization, Pathologic - therapy; Physiological aspects; Radiation therapy; Radiotherapy; Receptors, CXCR4 - antagonists & inhibitors; Receptors, CXCR4 - metabolism; Recruitment; Risk factors; Transplantation, Heterologous; Tumors; Whole-Body Irradiation; United States

Despite the high doses of radiation delivered in the treatment of patients with glioblastoma multiforme (GBM), the tumors invariably recur within the irradiation field, resulting in a low cure rate. Understanding the mechanism of such recurrence is therefore important. Here we have shown in an intra...