Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor

• Published in: Nature (London) Vol. 470; no. 7335; pp. 492 - 497
• Main Authors: Ressler, Kerry J., Mercer, Kristina B., Bradley, Bekh, Jovanovic, Tanja, Mahan, Amy, Kerley, Kimberly, Norrholm, Seth D., Kilaru, Varun, Smith, Alicia K., Myers, Amanda J., Ramirez, Manuel, Engel, Anzhelika, Hammack, Sayamwong E., Toufexis, Donna, Braas, Karen M., Binder, Elisabeth B., May, Victor
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.02.2011; Nature Publishing Group
• Subjects: 631/378/1689/1830; 692/420/2489/144; 692/53; Adult and adolescent clinical studies; Amygdala - metabolism; Animals; Anxiety disorders. Neuroses; Biological and medical sciences; Causes of; Conditioning, Classical - physiology; CpG Islands - genetics; DNA Methylation; Estrogens - metabolism; Estrogens - pharmacology; Fear - physiology; Female; Females; Gene expression; Gene Expression Regulation - drug effects; Genetic aspects; Genetic Association Studies; Genetic Predisposition to Disease - genetics; Humanities and Social Sciences; Humans; Male; Males; Medical sciences; Mice; multidisciplinary; Physiological aspects; Pituitary Adenylate Cyclase-Activating Polypeptide - blood; Pituitary Adenylate Cyclase-Activating Polypeptide - chemistry; Polymorphism, Single Nucleotide - genetics; Polypeptides; Post traumatic stress disorder; Psychological aspects; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Rats; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics; Response Elements - genetics; RNA, Messenger - analysis; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Rodents; Science; Science (multidisciplinary); Septal Nuclei - drug effects; Septal Nuclei - metabolism; Sex Characteristics; Stress Disorders, Post-Traumatic - blood; Stress Disorders, Post-Traumatic - genetics; Stress Disorders, Post-Traumatic - physiopathology; Stress Disorders, Post-Traumatic - psychology; Studies; United States; Affect affectivity; Animal model; Amygdala; Rat; Central nervous system; Anxiety disorder; Estrogen; Neuroendocrine regulation; Posttraumatic stress disorder; Bed nucleus of the stria terminalis; Genetic determinism; Neuropeptide; Encephalon; Messenger RNA; Genetics; Woman; Amygdaloid nucleus; Pituitary adenylate cyclase activating peptide; Human; Rodentia; Basal ganglion; Gene expression; Ovarian hormone; PAC1 receptor; Stress; Fear; Vertebrata; Mammalia; Mouse; Animal; Single nucleotide polymorphism; Sex steroid hormone; Methylation

Pituitary adenylate cyclase-activating polypeptide (PACAP) is known to broadly regulate the cellular stress response. In contrast, it is unclear if the PACAP–PAC1 receptor pathway has a role in human psychological stress responses, such as post-traumatic stress disorder (PTSD). Here we find, in heav...