Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor - Ressler, Kerry J.; Mercer, Kristina B.; Bradley, Bekh; Jovanovic, Tanja; Mahan, Amy; Kerley, Kimberly; Norrholm, Seth D.; Kilaru, Varun; Smith, Alicia K.; Myers, Amanda J.; Ramirez, Manuel; Engel, Anzhelika; et al. (Nature (London), 2011)
Keywords: 631/378/1689/1830; 692/420/2489/144; 692/53; Adult and adolescent clinical studies; Amygdala - metabolism; Animals; Anxiety disorders. Neuroses; Biological and medical sciences; Causes of; Conditioning, Classical - physiology; CpG Islands - genetics; DNA Methylation; Estrogens - metabolism; Estrogens - pharmacology; Fear - physiology; Female; Females; Gene expression; Gene Expression Regulation - drug effects; Genetic aspects; Genetic Association Studies; Genetic Predisposition to Disease - genetics; Humanities and Social Sciences; Humans; Male; Males; Medical sciences; Mice; multidisciplinary; Physiological aspects; Pituitary Adenylate Cyclase-Activating Polypeptide - blood; Pituitary Adenylate Cyclase-Activating Polypeptide - chemistry; Polymorphism, Single Nucleotide - genetics; Polypeptides; Post traumatic stress disorder; Psychological aspects; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Rats; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics; Response Elements - genetics; RNA, Messenger - analysis; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Rodents; Science; Science (multidisciplinary); Septal Nuclei - drug effects; Septal Nuclei - metabolism; Sex Characteristics; Stress Disorders, Post-Traumatic - blood; Stress Disorders, Post-Traumatic - genetics; Stress Disorders, Post-Traumatic - physiopathology; Stress Disorders, Post-Traumatic - psychology; Studies; United States; Affect affectivity; Animal model; Amygdala; Rat; Central nervous system; Anxiety disorder; Estrogen; Neuroendocrine regulation; Posttraumatic stress disorder; Bed nucleus of the stria terminalis; Genetic determinism; Neuropeptide; Encephalon; Messenger RNA; Genetics; Woman; Amygdaloid nucleus; Pituitary adenylate cyclase activating peptide; Human; Rodentia; Basal ganglion; Gene expression; Ovarian hormone; PAC1 receptor; Stress; Fear; Vertebrata; Mammalia; Mouse; Animal; Single nucleotide polymorphism; Sex steroid hormone; Methylation