ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome

• Published in: Journal of microbiology, immunology and infection Vol. 53; no. 3; pp. 425 - 435
• Main Authors: Devaux, Christian A., Rolain, Jean-Marc, Raoult, Didier
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.06.2020; Elsevier; Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC
• Subjects: ACE2; Amino Acid Sequence - genetics; Angiotensin-Converting Enzyme 2; Bacteriology; Betacoronavirus - metabolism; Cardiac failure; Cardiology and cardiovascular system; Coronavirus Infections - pathology; COVID-19; Emerging diseases; Female; Genetic Predisposition to Disease - genetics; Heart Failure - virology; Human health and pathology; Humans; Hypertension; Infectious diseases; Life Sciences; Male; Microbiology and Parasitology; Mini Review; Multiple Organ Failure - virology; Pandemics; Parasitology; Peptidyl-Dipeptidase A - genetics; Peptidyl-Dipeptidase A - metabolism; Pneumonia, Viral - pathology; Polymorphism, Single Nucleotide - genetics; SARS-CoV-2; Spike Glycoprotein, Coronavirus - metabolism; Virology; Virus Attachment; COVID-19; Hypertension; Cardiac failure; ACE2; SARS-CoV-2

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged in Chinese people in December 2019 and has currently spread worldwide causing the COVID-19 pandemic with more than 150,000 deaths. In order for a SARS-CoV like virus circulating in wild life for a very long time to infect...