Deletion polymorphism of the UGT2B17 gene is associated with increased risk for prostate cancer and correlated to gene expression in the prostate

• Published in: The pharmacogenomics journal Vol. 8; no. 2; pp. 147 - 151
• Main Authors: Karypidis, A-H, Olsson, M, Andersson, S-O, Rane, A, Ekström, L
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2008; Nature Publishing Group
• Subjects: Aged; Alleles; Analysis; Androgens; Androgens - metabolism; Biomedical and Life Sciences; Biomedicine; Case-Control Studies; Clinical genetics; Dermatologi och venerologi, klinisk genetik, invärtesmedicin; Dermatology and venerology,clinical genetics, internal medicine; FARMACI; Gene Deletion; Gene Expression; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Frequency; Gene polymorphism; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease; Glucuronosyltransferase - analysis; Glucuronosyltransferase - genetics; Glucuronosyltransferase/analysis/genetics; Health aspects; Heterozygotes; Homozygote; Human Genetics; Humans; Insertion; Kirurgi; Klinisk genetik; Male; Medical Genetics; MEDICIN; Medicin och hälsovetenskap; MEDICINE; Medicinsk genetik; Middle Aged; Minor Histocompatibility Antigens; Odds Ratio; Oncology; Onkologi; original-article; Pharmacotherapy; PHARMACY; Phenotype; Physiological aspects; Polymerase Chain Reaction; Polymorphism; Population studies; Prostate - enzymology; Prostate cancer; Prostatic Neoplasms - enzymology; Prostatic Neoplasms - genetics; Prostatic Neoplasms/enzymology/genetics; Psychopharmacology; Risk Assessment; Risk Factors; RNA, Messenger - analysis; Steroids; Surgery; Sweden; Testosterone; Up-Regulation; Sweden; androgen metabolism; UGT2B17; prostate cancer; testosterone; deletion; dihydrotestosterone; Enzymologic; Messenger/analysis; RNA; Neoplastic; Gene Expression Regulation

Metabolism of androgens includes glucuronidation, the major pathway of steroid elimination in several steroid target tissues. Glucuronidation is catalysed by UDP-glucuronosyltransferases (UGTs). UGT2B17 has been shown to be particularly active against androgens and is highly abundant in the prostate...