Establishment of a lethal mouse model of emerging tick-borne orthonairovirus infections

Emerging and reemerging tick-borne virus infections caused by orthonairoviruses (family Nairoviridae ), which are genetically distinct from Crimean-Congo hemorrhagic fever virus, have been recently reported in East Asia. Here, we have established a mouse infection model using type-I/II interferon re...

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Published inPLoS pathogens Vol. 20; no. 3; p. e1012101
Main Authors Ariizumi, Takuma, Tabata, Koshiro, Itakura, Yukari, Kobayashi, Hiroko, Hall, William W., Sasaki, Michihito, Sawa, Hirofumi, Matsuno, Keita, Orba, Yasuko
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.03.2024
Public Library of Science (PLoS)
Subjects
Analysis
Analysis and chemistry
Antigens
Antiviral agents
Antiviral drugs
Arachnids
Biochemistry
Biological response modifiers
Bites and stings
Blood
Body weight
Body weight loss
Care and treatment
Crimean hemorrhagic fever
Diagnosis
Dosage and administration
Enzymes
Fatalities
Females
Glucose
Health aspects
Hemorrhagic fever
Hepatitis
Infections
Insect bites
Interferon
Kinases
Leukopenia
Liver
Pathogenesis
Pathogenicity
Pathogens
Proteins
Risk factors
Spleen
Standard deviation
Thrombocytopenia
Tick-borne diseases
Viruses
Weight loss
Congo (Kinshasa)
Japan
China
Ukraine
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Abstract Emerging and reemerging tick-borne virus infections caused by orthonairoviruses (family Nairoviridae ), which are genetically distinct from Crimean-Congo hemorrhagic fever virus, have been recently reported in East Asia. Here, we have established a mouse infection model using type-I/II interferon receptor-knockout mice (AG129 mice) both for a better understanding of the pathogenesis of these infections and validation of antiviral agents using Yezo virus (YEZV), a novel orthonairovirus causing febrile illnesses associated with tick bites in Japan and China. YEZV-inoculated AG129 mice developed hepatitis with body weight loss and died by 6 days post infection. Blood biochemistry tests showed elevated liver enzyme levels, similar to YEZV-infected human patients. AG129 mice treated with favipiravir survived lethal YEZV infection, demonstrating the anti-YEZV effect of this drug. The present mouse model will help us better understand the pathogenicity of the emerging tick-borne orthonairoviruses and the development of specific antiviral agents for their treatment.
AbstractList Emerging and reemerging tick-borne virus infections caused by orthonairoviruses (family Nairoviridae), which are genetically distinct from Crimean-Congo hemorrhagic fever virus, have been recently reported in East Asia. Here, we have established a mouse infection model using type-I/II interferon receptor-knockout mice (AG129 mice) both for a better understanding of the pathogenesis of these infections and validation of antiviral agents using Yezo virus (YEZV), a novel orthonairovirus causing febrile illnesses associated with tick bites in Japan and China. YEZV-inoculated AG129 mice developed hepatitis with body weight loss and died by 6 days post infection. Blood biochemistry tests showed elevated liver enzyme levels, similar to YEZV-infected human patients. AG129 mice treated with favipiravir survived lethal YEZV infection, demonstrating the anti-YEZV effect of this drug. The present mouse model will help us better understand the pathogenicity of the emerging tick-borne orthonairoviruses and the development of specific antiviral agents for their treatment.
Emerging and reemerging tick-borne virus infections caused by orthonairoviruses (family Nairoviridae), which are genetically distinct from Crimean-Congo hemorrhagic fever virus, have been recently reported in East Asia. Here, we have established a mouse infection model using type-I/II interferon receptor-knockout mice (AG129 mice) both for a better understanding of the pathogenesis of these infections and validation of antiviral agents using Yezo virus (YEZV), a novel orthonairovirus causing febrile illnesses associated with tick bites in Japan and China. YEZV-inoculated AG129 mice developed hepatitis with body weight loss and died by 6 days post infection. Blood biochemistry tests showed elevated liver enzyme levels, similar to YEZV-infected human patients. AG129 mice treated with favipiravir survived lethal YEZV infection, demonstrating the anti-YEZV effect of this drug. The present mouse model will help us better understand the pathogenicity of the emerging tick-borne orthonairoviruses and the development of specific antiviral agents for their treatment.Emerging and reemerging tick-borne virus infections caused by orthonairoviruses (family Nairoviridae), which are genetically distinct from Crimean-Congo hemorrhagic fever virus, have been recently reported in East Asia. Here, we have established a mouse infection model using type-I/II interferon receptor-knockout mice (AG129 mice) both for a better understanding of the pathogenesis of these infections and validation of antiviral agents using Yezo virus (YEZV), a novel orthonairovirus causing febrile illnesses associated with tick bites in Japan and China. YEZV-inoculated AG129 mice developed hepatitis with body weight loss and died by 6 days post infection. Blood biochemistry tests showed elevated liver enzyme levels, similar to YEZV-infected human patients. AG129 mice treated with favipiravir survived lethal YEZV infection, demonstrating the anti-YEZV effect of this drug. The present mouse model will help us better understand the pathogenicity of the emerging tick-borne orthonairoviruses and the development of specific antiviral agents for their treatment.
Emerging and reemerging tick-borne virus infections caused by orthonairoviruses (family Nairoviridae ), which are genetically distinct from Crimean-Congo hemorrhagic fever virus, have been recently reported in East Asia. Here, we have established a mouse infection model using type-I/II interferon receptor-knockout mice (AG129 mice) both for a better understanding of the pathogenesis of these infections and validation of antiviral agents using Yezo virus (YEZV), a novel orthonairovirus causing febrile illnesses associated with tick bites in Japan and China. YEZV-inoculated AG129 mice developed hepatitis with body weight loss and died by 6 days post infection. Blood biochemistry tests showed elevated liver enzyme levels, similar to YEZV-infected human patients. AG129 mice treated with favipiravir survived lethal YEZV infection, demonstrating the anti-YEZV effect of this drug. The present mouse model will help us better understand the pathogenicity of the emerging tick-borne orthonairoviruses and the development of specific antiviral agents for their treatment.
Audience Academic
Author Tabata, Koshiro
Ariizumi, Takuma
Itakura, Yukari
Orba, Yasuko
Sawa, Hirofumi
Matsuno, Keita
Kobayashi, Hiroko
Hall, William W.
Sasaki, Michihito
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CitedBy_id crossref_primary_10_1016_S1473_3099_24_00658_3
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crossref_primary_10_1016_S1473_3099_24_00616_9
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Snippet Emerging and reemerging tick-borne virus infections caused by orthonairoviruses (family Nairoviridae ), which are genetically distinct from Crimean-Congo...
Emerging and reemerging tick-borne virus infections caused by orthonairoviruses (family Nairoviridae), which are genetically distinct from Crimean-Congo...
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StartPage e1012101
SubjectTerms Analysis
Analysis and chemistry
Antigens
Antiviral agents
Antiviral drugs
Arachnids
Biochemistry
Biological response modifiers
Bites and stings
Blood
Body weight
Body weight loss
Care and treatment
Crimean hemorrhagic fever
Diagnosis
Dosage and administration
Enzymes
Fatalities
Females
Glucose
Health aspects
Hemorrhagic fever
Hepatitis
Infections
Insect bites
Interferon
Kinases
Leukopenia
Liver
Pathogenesis
Pathogenicity
Pathogens
Proteins
Risk factors
Spleen
Standard deviation
Thrombocytopenia
Tick-borne diseases
Viruses
Weight loss
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Title Establishment of a lethal mouse model of emerging tick-borne orthonairovirus infections
URI https://www.ncbi.nlm.nih.gov/pubmed/38502642
https://www.proquest.com/docview/3069183773
https://www.proquest.com/docview/2972702037
https://doaj.org/article/0beaf9e9271e459d8707edbe54304a4e
http://dx.doi.org/10.1371/journal.ppat.1012101
Volume 20
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