Circulating MicroRNA Expression Profiles Associated With Systemic Lupus Erythematosus

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 65; no. 5; pp. 1324 - 1334
• Main Authors: Carlsen, Anting Liu, Schetter, Aaron J., Nielsen, Christoffer T., Lood, Christian, Knudsen, Steen, Voss, Anne, Harris, Curtis C., Hellmark, Thomas, Segelmark, Mårten, Jacobsen, Søren, Bengtsson, Anders A., Heegaard, Niels H. H.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.05.2013; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - diagnosis; Arthritis, Rheumatoid - genetics; Biomarkers - blood; Clinical Medicine; Cohort Studies; Female; Gene Expression Profiling; Humans; Immunocompromised Host; Klinisk medicin; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - diagnosis; Lupus Erythematosus, Systemic - genetics; Male; Medical and Health Sciences; MEDICIN; Medicin och hälsovetenskap; MEDICINE; MicroRNAs - blood; MicroRNAs - classification; Middle Aged; Signal Transduction - genetics; Transforming Growth Factor beta - genetics; Transforming Growth Factor beta - metabolism; Vasculitis - blood; Vasculitis - genetics; Young Adult

Objective To evaluate the specificity of expression patterns of cell‐free circulating microRNAs (miRNAs) in systemic lupus erythematosus (SLE). Methods Total RNA was purified from plasma, and 45 different specific, mature miRNAs were determined using quantitative reverse transcription–polymerase cha...