R-spondin 3 governs secretory differentiation in the gastric oxyntic glands

• Published in: The Journal of clinical investigation Vol. 132; no. 21
• Main Authors: Kurokawa, Ken, Wang, Timothy C., Hayakawa, Yoku
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.11.2022
• Subjects: Animals; Cell Differentiation - physiology; Gastric Mucosa - metabolism; Mice; Organoids - metabolism; Stem Cell Niche; Stem Cells - metabolism
• ISSN: 1558-8238; 0021-9738; 1558-8238
• DOI: 10.1172/JCI163380

The gastric oxyntic glands are maintained by gastric stem cells that continuously supply all differentiated cell types within the corpus epithelium. Stem cells are supported by stromal cells that make up the stem cell niche. In this issue of the JCI, Fischer et al. report on their use of genetically...