Yb Integrates piRNA Intermediates and Processing Factors into Perinuclear Bodies to Enhance piRISC Assembly
PIWI-interacting RNAs (piRNAs) direct Piwi to repress transposons and maintain genome integrity in Drosophila ovarian somatic cells. piRNA maturation and association with Piwi occur at perinuclear Yb bodies, the centers of piRNA biogenesis. Here, we show that piRNA intermediates arising from the piR...
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Published in | Cell reports (Cambridge) Vol. 8; no. 1; pp. 103 - 113 |
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Main Authors | , , , , , , , , , |
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Abstract | PIWI-interacting RNAs (piRNAs) direct Piwi to repress transposons and maintain genome integrity in Drosophila ovarian somatic cells. piRNA maturation and association with Piwi occur at perinuclear Yb bodies, the centers of piRNA biogenesis. Here, we show that piRNA intermediates arising from the piRNA cluster flamenco (flam) localize to perinuclear foci adjacent to Yb bodies, termed Flam bodies. RNAi-based screening of piRNA factors revealed that Flam body formation depends on Yb, the core component of Yb bodies, while Piwi and another Yb body component, Armitage, are dispensable for formation. Abolishing the RNA-binding activity of Yb disrupts both Flam bodies and Yb bodies. Yb directly binds flam, but not transcripts from neighboring protein-coding genes. Thus, Yb integrates piRNA intermediates and piRNA processing factors selectively into Flam bodies and Yb bodies, respectively. We suggest that Yb is a key upstream factor in the cytoplasmic phase of the piRNA pathway in ovarian somatic cells.
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•piRNA intermediates localize to perinuclear Flam bodies adjacent to Yb bodies•The RNA-binding activity of Yb is required for Flam body and Yb body formation•Yb directly binds flam transcripts, but not neighboring protein-coding gene mRNAs•Yb is the most upstream factor in the cytoplasmic phase of the piRNA pathway
piRNAs form complexes with Piwi protein and direct these piRISCs to repress transposons and maintain genome integrity in the gonads. piRNA maturation and piRISC formation occur at Yb bodies. In this study, Murota et al. find that piRNA intermediates arising from the flam locus localize to Flam bodies adjacent to Yb bodies. Yb, crucial for piRNA-mediated silencing, integrates piRNA intermediates and piRNA factors selectively into Flam bodies and Yb bodies, respectively. |
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AbstractList | PIWI-interacting RNAs (piRNAs) direct Piwi to repress transposons and maintain genome integrity in Drosophila ovarian somatic cells. piRNA maturation and association with Piwi occur at perinuclear Yb bodies, the centers of piRNA biogenesis. Here, we show that piRNA intermediates arising from the piRNA cluster flamenco (flam) localize to perinuclear foci adjacent to Yb bodies, termed Flam bodies. RNAi-based screening of piRNA factors revealed that Flam body formation depends on Yb, the core component of Yb bodies, while Piwi and another Yb body component, Armitage, are dispensable for formation. Abolishing the RNA-binding activity of Yb disrupts both Flam bodies and Yb bodies. Yb directly binds flam, but not transcripts from neighboring protein-coding genes. Thus, Yb integrates piRNA intermediates and piRNA processing factors selectively into Flam bodies and Yb bodies, respectively. We suggest that Yb is a key upstream factor in the cytoplasmic phase of the piRNA pathway in ovarian somatic cells.
[Display omitted]
•piRNA intermediates localize to perinuclear Flam bodies adjacent to Yb bodies•The RNA-binding activity of Yb is required for Flam body and Yb body formation•Yb directly binds flam transcripts, but not neighboring protein-coding gene mRNAs•Yb is the most upstream factor in the cytoplasmic phase of the piRNA pathway
piRNAs form complexes with Piwi protein and direct these piRISCs to repress transposons and maintain genome integrity in the gonads. piRNA maturation and piRISC formation occur at Yb bodies. In this study, Murota et al. find that piRNA intermediates arising from the flam locus localize to Flam bodies adjacent to Yb bodies. Yb, crucial for piRNA-mediated silencing, integrates piRNA intermediates and piRNA factors selectively into Flam bodies and Yb bodies, respectively. PIWI-interacting RNAs (piRNAs) direct Piwi to repress transposons and maintain genome integrity in Drosophila ovarian somatic cells. piRNA maturation and association with Piwi occur at perinuclear Yb bodies, the centers of piRNA biogenesis. Here, we show that piRNA intermediates arising from the piRNA cluster flamenco (flam) localize to perinuclear foci adjacent to Yb bodies, termed Flam bodies. RNAi-based screening of piRNA factors revealed that Flam body formation depends on Yb, the core component of Yb bodies, while Piwi and another Yb body component, Armitage, are dispensable for formation. Abolishing the RNA-binding activity of Yb disrupts both Flam bodies and Yb bodies. Yb directly binds flam, but not transcripts from neighboring protein-coding genes. Thus, Yb integrates piRNA intermediates and piRNA processing factors selectively into Flam bodies and Yb bodies, respectively. We suggest that Yb is a key upstream factor in the cytoplasmic phase of the piRNA pathway in ovarian somatic cells. PIWI-interacting RNAs (piRNAs) direct Piwi to repress transposons and maintain genome integrity in Drosophila ovarian somatic cells. piRNA maturation and association with Piwi occur at perinuclear Yb bodies, the centers of piRNA biogenesis. Here, we show that piRNA intermediates arising from the piRNA cluster flamenco (flam) localize to perinuclear foci adjacent to Yb bodies, termed Flam bodies. RNAi-based screening of piRNA factors revealed that Flam body formation depends on Yb, the core component of Yb bodies, while Piwi and another Yb body component, Armitage, are dispensable for formation. Abolishing the RNA-binding activity of Yb disrupts both Flam bodies and Yb bodies. Yb directly binds flam, but not transcripts from neighboring protein-coding genes. Thus, Yb integrates piRNA intermediates and piRNA processing factors selectively into Flam bodies and Yb bodies, respectively. We suggest that Yb is a key upstream factor in the cytoplasmic phase of the piRNA pathway in ovarian somatic cells. |
Author | Shibata, Shinsuke Saito, Kuniaki Kamatani, Miharu K. Ishizu, Hirotsugu Murota, Yukiko Iwasaki, Yuka W. Siomi, Mikiko C. Nakagawa, Shinichi Siomi, Haruhiko Okano, Hideyuki |
Author_xml | – sequence: 1 givenname: Yukiko surname: Murota fullname: Murota, Yukiko organization: Institute for Genome Research, University of Tokushima, Tokushima 770-8503, Japan – sequence: 2 givenname: Hirotsugu surname: Ishizu fullname: Ishizu, Hirotsugu organization: Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0032, Japan – sequence: 3 givenname: Shinichi surname: Nakagawa fullname: Nakagawa, Shinichi organization: RIKEN, Wako, Saitama 351-0198, Japan – sequence: 4 givenname: Yuka W. surname: Iwasaki fullname: Iwasaki, Yuka W. organization: Department of Molecular Biology, Keio University School of Medicine, Tokyo 160-8582, Japan – sequence: 5 givenname: Shinsuke surname: Shibata fullname: Shibata, Shinsuke organization: Department of Biomedical Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan – sequence: 6 givenname: Miharu K. surname: Kamatani fullname: Kamatani, Miharu K. organization: Department of Molecular Biology, Keio University School of Medicine, Tokyo 160-8582, Japan – sequence: 7 givenname: Kuniaki surname: Saito fullname: Saito, Kuniaki organization: Department of Molecular Biology, Keio University School of Medicine, Tokyo 160-8582, Japan – sequence: 8 givenname: Hideyuki surname: Okano fullname: Okano, Hideyuki organization: Department of Biomedical Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan – sequence: 9 givenname: Haruhiko surname: Siomi fullname: Siomi, Haruhiko organization: Department of Molecular Biology, Keio University School of Medicine, Tokyo 160-8582, Japan – sequence: 10 givenname: Mikiko C. surname: Siomi fullname: Siomi, Mikiko C. email: siomim@bs.s.u-tokyo.ac.jp organization: Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0032, Japan |
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SubjectTerms | Animals Argonaute Proteins - genetics Argonaute Proteins - metabolism Cells, Cultured Drosophila - genetics Drosophila Proteins - genetics Drosophila Proteins - metabolism Female Ovary - cytology Ovary - metabolism Protein Binding RNA Helicases - genetics RNA Helicases - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNA-Induced Silencing Complex - metabolism |
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Title | Yb Integrates piRNA Intermediates and Processing Factors into Perinuclear Bodies to Enhance piRISC Assembly |
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