Galectin-3 is elevated in CSF and is associated with Aβ deposits and tau aggregates in brain tissue in Alzheimer’s disease

• Published in: Acta neuropathologica Vol. 144; no. 5; pp. 843 - 859
• Main Authors: Boza-Serrano, Antonio, Vrillon, Agathe, Minta, Karolina, Paulus, Agnes, Camprubí-Ferrer, Lluís, Garcia, Megg, Andreasson, Ulf, Antonell, Anna, Wennström, Malin, Gouras, Gunnar, Dumurgier, Julien, Cognat, Emmanuel, Molina-Porcel, Laura, Balasa, Mircea, Vitorica, Javier, Sánchez-Valle, Raquel, Paquet, Claire, Venero, Jose Luis, Blennow, Kaj, Deierborg, Tomas
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2022; Springer Nature B.V
• Subjects: Age; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Animal models; Animals; Basic Medicine; beta-Galactosidase - metabolism; Biomarkers; Biomarkers - cerebrospinal fluid; Brain - pathology; Central nervous system; Cerebrospinal fluid; Chitinase-3-Like Protein 1 - metabolism; Galectin 3; GAP-43 protein; GAP-43 Protein - metabolism; Glial fibrillary acidic protein; Hippocampus; Humans; Immunohistochemistry; Inflammation; Medical and Health Sciences; Medicin och hälsovetenskap; Medicine; Medicine & Public Health; Medicinska och farmaceutiska grundvetenskaper; Mice; microglia; Microglial cells; Neurodegeneration; Neurodegenerative diseases; Neurogranin; Neurosciences; Neurosciences & Neurology; Neurovetenskaper; Original Paper; Pathology; pathway; Plaque, Amyloid - pathology; Principal components analysis; receptor; Senile plaques; strem2; Tau protein; tau Proteins - metabolism; β-Amyloid; β-Galactosidase

Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial activation in the central nervous system (CNS). We previously demonstrated the crucial deleterious role of Gal-3 in microglial activation in Alzheimer’s disease (AD). Under AD conditions, Gal-3 is primarily expressed b...