Individual risk of post-ivermectin serious adverse events in subjects infected with Loa loa

• Published in: EClinicalMedicine Vol. 28; p. 100582
• Main Authors: Chesnais, Cédric B., Pion, Sébastien D., Boullé, Charlotte, Gardon, Jacques, Gardon-Wendel, Nathalie, Fokom-Domgue, Joël, Kamgno, Joseph, Boussinesq, Michel
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2020; Elsevier
• Subjects: Africa; Human health and pathology; Infectious diseases; Internal Medicine; Life Sciences; Loiasis; Pharmaceutical sciences; Pharmacology; Research Paper; Serious adverse events; Loiasis; Africa; Serious adverse events

Implementation of onchocerciasis elimination programmes has been delayed in Central Africa because of the risk of ivermectin-related serious adverse events (SAEs) in individuals with high Loa loa microfilarial densities (MFD). We developed the first statistical models enabling prediction of SAE risk...