TRPV1 activation counters diet-induced obesity through sirtuin-1 activation and PRDM-16 deacetylation in brown adipose tissue

• Published in: International Journal of Obesity Vol. 41; no. 5; pp. 739 - 749
• Main Authors: Baskaran, P, Krishnan, V, Fettel, K, Gao, P, Zhu, Z, Ren, J, Thyagarajan, B
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2017; Nature Publishing Group
• Subjects: 13; 13/106; 13/95; 631/80/458; 631/80/458/1275; 631/80/86; 64/60; 692/699/2743/393; 82; 82/80; Acetylation; Acetylation - drug effects; Adipose tissue; Adipose tissue (brown); Adipose Tissue, Brown - drug effects; Adipose Tissue, Brown - metabolism; Animals; Anti-Obesity Agents - pharmacology; Body fat; Body weight loss; Calcium (intracellular); Calcium ions; Calcium permeability; Capsaicin; Capsaicin - pharmacology; Capsaicin receptors; Capsazepine; Care and treatment; Chelation; Deacetylation; Diet; Diet, High-Fat - adverse effects; Dietary supplements; Disease Models, Animal; DNA-Binding Proteins - metabolism; Energy; Energy expenditure; Energy intake; Energy Intake - physiology; Energy metabolism; Energy Metabolism - physiology; Epidemiology; Experiments; Genetic aspects; Glucagon; Glucagon-like peptide 1; Glucose tolerance; Health Promotion and Disease Prevention; High fat diet; Hypercholesterolemia; Hypertension; Immunoblotting; Internal Medicine; Intolerance; Lipolysis; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Mice; Mice, Knockout; Nutritional aspects; Obesity; Obesity - drug therapy; Obesity - metabolism; Obesity - prevention & control; original-article; Peroxisome proliferator-activated receptors; Pharmacy; Phosphorylation; Proteins; Public Health; Quotients; Receptors; Sirtuin 1 - metabolism; Thermogenesis; Thermogenesis - drug effects; Transcription Factors - metabolism; TRPV Cation Channels - agonists; TRPV Cation Channels - metabolism; Up-Regulation; Weight control; Weight loss; Zinc finger proteins; United States > US

Background/objective: An imbalance between energy intake and expenditure leads to obesity. Increasing metabolism and thermogenesis in brown adipose tissue (BAT) can help in overcoming obesity. Here, we investigated the effect of activation of transient receptor potential vanilloid subfamily 1 (TRPV1...