Mitochondrial replacement therapy and assisted reproductive technology: A paradigm shift toward treatment of genetic diseases in gametes or in early embryos

• Published in: Reproductive medicine and biology Vol. 17; no. 4; pp. 421 - 433
• Main Authors: Tachibana, Masahito, Kuno, Takashi, Yaegashi, Nobuo
• Format: Journal Article
• Language: English
• Published: Japan John Wiley & Sons, Inc 01.10.2018; John Wiley and Sons Inc; Wiley
• Subjects: Ataxia; Biosynthesis; Cytoplasm; Defects; Deoxyribonucleic acid; Disease; DNA; Embryology; Fertilization; Gametes; Gene therapy; Genes; Genetic counseling; Genetic disorders; Genetic research; Genetically modified organisms; Genomes; Genotype & phenotype; germ line gene therapy; Haplotypes; maternal spindle transfer (MST); Medical research; Medicine, Experimental; Mitochondria; mitochondrial bottleneck effect; mitochondrial diseases; Mitochondrial DNA; mitochondrial replacement therapy (MRT); Mutation; Phosphorylation; Political aspects; Reproductive technology; Reversion; Review; Sperm; Stem cells; United Kingdom > UK; mitochondrial bottleneck effect; mitochondrial diseases; maternal spindle transfer (MST); germ line gene therapy; mitochondrial replacement therapy (MRT)

Background Recent technological development allows nearly complete replacement of the cytoplasm of egg/embryo, eliminating the transmission of undesired defective mitochondria (mutated mitochondrial DNA: mtDNA) for patients with inherited mitochondrial diseases, which is called mitochondrial replace...