Proteins, peptides, polysaccharides, and nucleotides with inhibitory activity on human immunodeficiency virus and its enzymes

• Published in: Applied microbiology and biotechnology Vol. 99; no. 24; pp. 10399 - 10414
• Main Authors: Ng, Tzi Bun, Cheung, Randy Chi Fai, Wong, Jack Ho, Chan, Wai Yee
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2015; Springer; Springer Nature B.V
• Subjects: Acquired immune deficiency syndrome; acquired immunodeficiency syndrome; AIDS; AIDS (Disease); Analysis; Anti-HIV agents; Anti-HIV Agents - pharmacology; Antifungal agents; antifungal proteins; antiretroviral agents; antiretroviral properties; Antiviral activity; Apoptosis; Biological Products - pharmacology; Biomedical and Life Sciences; Biomolecules; Biotechnology; Breast cancer; Cathelicidins; Chitinase; Defensins; Drug therapy; Enzyme Inhibitors - pharmacology; Enzymes; Fungicides; Health aspects; HIV; HIV - drug effects; Human immunodeficiency virus; Immune system; Inhibitor drugs; Lectins; Lentivirus; Life Sciences; Microbial Genetics and Genomics; Microbiology; Milk; milk proteins; Mini-Review; Natural products; nucleosides; Nucleotides; Nucleotides - pharmacology; Peptides; Polysaccharides; Polysaccharides - pharmacology; Proteins; Proteins - pharmacology; Replication; Retroviridae; ribonucleases; Ribonucleic acid; Ribozymes; RNA; Saccharides; Seeds; Studies; Synthetic peptides; Trypsin; Trypsin inhibitors; China; Proteins; Polysaccharides; Anti-HIV; Ribozymes; Nucleic acids; Peptides
• ISSN: 0175-7598; 1432-0614; 1432-0614
• DOI: 10.1007/s00253-015-6997-z

Human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome, has claimed innumerable lives in the past. Many biomolecules which suppress HIV replication and also other biomolecules that inhibit enzymes essential to HIV replication have been reported. Proteins including a variety of milk proteins, ribosome-inactivating proteins, ribonucleases, antifungal proteins, and trypsin inhibitors; peptides comprising cathelicidins, defensins, synthetic peptides, and others; polysaccharides and polysaccharopeptides; nucleosides, nucleotides, and ribozymes, demonstrated anti-HIV activity. In many cases, the mechanism of anti-HIV action has been elucidated. Strategies have been devised to augment the anti-HIV potency of these compounds.