Proteins, peptides, polysaccharides, and nucleotides with inhibitory activity on human immunodeficiency virus and its enzymes

Human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome, has claimed innumerable lives in the past. Many biomolecules which suppress HIV replication and also other biomolecules that inhibit enzymes essential to HIV replication have been reported. Proteins inclu...

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Published inApplied microbiology and biotechnology Vol. 99; no. 24; pp. 10399 - 10414
Main Authors Ng, Tzi Bun, Cheung, Randy Chi Fai, Wong, Jack Ho, Chan, Wai Yee
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2015
Springer
Springer Nature B.V
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Abstract Human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome, has claimed innumerable lives in the past. Many biomolecules which suppress HIV replication and also other biomolecules that inhibit enzymes essential to HIV replication have been reported. Proteins including a variety of milk proteins, ribosome-inactivating proteins, ribonucleases, antifungal proteins, and trypsin inhibitors; peptides comprising cathelicidins, defensins, synthetic peptides, and others; polysaccharides and polysaccharopeptides; nucleosides, nucleotides, and ribozymes, demonstrated anti-HIV activity. In many cases, the mechanism of anti-HIV action has been elucidated. Strategies have been devised to augment the anti-HIV potency of these compounds.
AbstractList Human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome, has claimed innumerable lives in the past. Many biomolecules which suppress HIV replication and also other biomolecules that inhibit enzymes essential to HIV replication have been reported. Proteins including a variety of milk proteins, ribosome-inactivating proteins, ribonucleases, antifungal proteins, and trypsin inhibitors; peptides comprising cathelicidins, defensins, synthetic peptides, and others; polysaccharides and polysaccharopeptides; nucleosides, nucleotides, and ribozymes, demonstrated anti-HIV activity. In many cases, the mechanism of anti-HIV action has been elucidated. Strategies have been devised to augment the anti-HIV potency of these compounds.
Human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome, has claimed innumerable lives in the past. Many biomolecules which suppress HIV replication and also other biomolecules that inhibit enzymes essential to HIV replication have been reported. Proteins including a variety of milk proteins, ribosome-inactivating proteins, ribonucleases, antifungal proteins, and trypsin inhibitors; peptides comprising cathelicidins, defensins, synthetic peptides, and others; polysaccharides and polysaccharopeptides; nucleosides, nucleotides, and ribozymes, demonstrated anti-HIV activity. In many cases, the mechanism of anti-HIV action has been elucidated. Strategies have been devised to augment the anti-HIV potency of these compounds.Human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome, has claimed innumerable lives in the past. Many biomolecules which suppress HIV replication and also other biomolecules that inhibit enzymes essential to HIV replication have been reported. Proteins including a variety of milk proteins, ribosome-inactivating proteins, ribonucleases, antifungal proteins, and trypsin inhibitors; peptides comprising cathelicidins, defensins, synthetic peptides, and others; polysaccharides and polysaccharopeptides; nucleosides, nucleotides, and ribozymes, demonstrated anti-HIV activity. In many cases, the mechanism of anti-HIV action has been elucidated. Strategies have been devised to augment the anti-HIV potency of these compounds.
Audience Academic
Author Cheung, Randy Chi Fai
Chan, Wai Yee
Ng, Tzi Bun
Wong, Jack Ho
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/26411457$$D View this record in MEDLINE/PubMed
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Issue 24
Keywords Proteins
Polysaccharides
Anti-HIV
Ribozymes
Nucleic acids
Peptides
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Snippet Human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome, has claimed innumerable lives in the past. Many biomolecules...
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SubjectTerms Acquired immune deficiency syndrome
acquired immunodeficiency syndrome
AIDS
AIDS (Disease)
Analysis
Anti-HIV agents
Anti-HIV Agents - pharmacology
Antifungal agents
antifungal proteins
antiretroviral agents
antiretroviral properties
Antiviral activity
Apoptosis
Biological Products - pharmacology
Biomedical and Life Sciences
Biomolecules
Biotechnology
Breast cancer
Cathelicidins
Chitinase
Defensins
Drug therapy
Enzyme Inhibitors - pharmacology
Enzymes
Fungicides
Health aspects
HIV
HIV - drug effects
Human immunodeficiency virus
Immune system
Inhibitor drugs
Lectins
Lentivirus
Life Sciences
Microbial Genetics and Genomics
Microbiology
Milk
milk proteins
Mini-Review
Natural products
nucleosides
Nucleotides
Nucleotides - pharmacology
Peptides
Polysaccharides
Polysaccharides - pharmacology
Proteins
Proteins - pharmacology
Replication
Retroviridae
ribonucleases
Ribonucleic acid
Ribozymes
RNA
Saccharides
Seeds
Studies
Synthetic peptides
Trypsin
Trypsin inhibitors
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Title Proteins, peptides, polysaccharides, and nucleotides with inhibitory activity on human immunodeficiency virus and its enzymes
URI https://link.springer.com/article/10.1007/s00253-015-6997-z
https://www.ncbi.nlm.nih.gov/pubmed/26411457
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Volume 99
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