Antibacterial products of marine organisms
Marine organisms comprising microbes, plants, invertebrates, and vertebrates elaborate an impressive array of structurally diverse antimicrobial products ranging from small cyclic compounds to macromolecules such as proteins. Some of these biomolecules originate directly from marine animals while ot...
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Published in | Applied microbiology and biotechnology Vol. 99; no. 10; pp. 4145 - 4173 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer-Verlag
01.05.2015
Springer Berlin Heidelberg Springer Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Abstract | Marine organisms comprising microbes, plants, invertebrates, and vertebrates elaborate an impressive array of structurally diverse antimicrobial products ranging from small cyclic compounds to macromolecules such as proteins. Some of these biomolecules originate directly from marine animals while others arise from microbes associated with the animals. It is noteworthy that some of the biomolecules referred to above are structurally unique while others belong to known classes of compounds, peptides, and proteins. Some of the antibacterial agents are more active against Gram-positive bacteria while others have higher effectiveness on Gram-negative bacteria. Some are efficacious against both Gram-positive and Gram-negative bacteria and against drug-resistant strains as well. The mechanism of antibacterial action of a large number of the chemically identified antibacterial agents, possible synergism with currently used antibiotics, and the issue of possible toxicity on mammalian cells and tissues await elucidation. The structural characteristics pivotal to antibacterial activity have been ascertained in only a few studies. Demonstration of efficacy of the antibacterial agents in animal models of bacterial infection is highly desirable. Structural characterization of the active principles present in aqueous and organic extracts of marine organisms with reportedly antibacterial activity would be desirable. |
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AbstractList | Marine organisms comprising microbes, plants, invertebrates, and vertebrates elaborate an impressive array of structurally diverse antimicrobial products ranging from small cyclic compounds to macromolecules such as proteins. Some of these biomolecules originate directly from marine animals while others arise from microbes associated with the animals. It is noteworthy that some of the biomolecules referred to above are structurally unique while others belong to known classes of compounds, peptides, and proteins. Some of the antibacterial agents are more active against Gram-positive bacteria while others have higher effectiveness on Gram-negative bacteria. Some are efficacious against both Gram-positive and Gram-negative bacteria and against drug-resistant strains as well. The mechanism of antibacterial action of a large number of the chemically identified antibacterial agents, possible synergism with currently used antibiotics, and the issue of possible toxicity on mammalian cells and tissues await elucidation. The structural characteristics pivotal to antibacterial activity have been ascertained in only a few studies. Demonstration of efficacy of the antibacterial agents in animal models of bacterial infection is highly desirable. Structural characterization of the active principles present in aqueous and organic extracts of marine organisms with reportedly antibacterial activity would be desirable. |
Audience | Academic |
Author | Cheung, Randy Chi Fai Bekhit, Adnan A Ng, Tzi Bun Wong, Jack Ho Bekhit, Alaa El-Din |
Author_xml | – sequence: 1 fullname: Ng, Tzi Bun – sequence: 2 fullname: Cheung, Randy Chi Fai – sequence: 3 fullname: Wong, Jack Ho – sequence: 4 fullname: Bekhit, Adnan A – sequence: 5 fullname: Bekhit, Alaa El-Din |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25874533$$D View this record in MEDLINE/PubMed |
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Snippet | Marine organisms comprising microbes, plants, invertebrates, and vertebrates elaborate an impressive array of structurally diverse antimicrobial products... |
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SubjectTerms | Analysis Animal models Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Anti-infective agents Antibacterial activity Antibacterial agents antibacterial properties Antibiotics Antiinfectives and antibacterials Antimicrobial agents Aquatic animals Aquatic Organisms - chemistry Aquatic Organisms - metabolism Bacteria Bacteria - drug effects Bacterial diseases Bacterial infections Biomedical and Life Sciences Biomolecules Biosynthesis Biotechnology Cancer Cyclic compounds Drug resistance Effectiveness Gram-negative bacteria Gram-positive bacteria Health aspects invertebrates Life Sciences Mammalian cells mammals Marine animals Marine biology Marine organisms Medical research Microbial Genetics and Genomics Microbial Sensitivity Tests Microbiology Microorganisms Mini-Review Natural products Organisms Peptides Pharmaceutical industry Proteins Structural analysis Studies Synergism Testing tissues Toxicity Vertebrates |
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Title | Antibacterial products of marine organisms |
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