Antibacterial products of marine organisms

Marine organisms comprising microbes, plants, invertebrates, and vertebrates elaborate an impressive array of structurally diverse antimicrobial products ranging from small cyclic compounds to macromolecules such as proteins. Some of these biomolecules originate directly from marine animals while ot...

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Published inApplied microbiology and biotechnology Vol. 99; no. 10; pp. 4145 - 4173
Main Authors Ng, Tzi Bun, Cheung, Randy Chi Fai, Wong, Jack Ho, Bekhit, Adnan A, Bekhit, Alaa El-Din
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer-Verlag 01.05.2015
Springer Berlin Heidelberg
Springer
Springer Nature B.V
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Abstract Marine organisms comprising microbes, plants, invertebrates, and vertebrates elaborate an impressive array of structurally diverse antimicrobial products ranging from small cyclic compounds to macromolecules such as proteins. Some of these biomolecules originate directly from marine animals while others arise from microbes associated with the animals. It is noteworthy that some of the biomolecules referred to above are structurally unique while others belong to known classes of compounds, peptides, and proteins. Some of the antibacterial agents are more active against Gram-positive bacteria while others have higher effectiveness on Gram-negative bacteria. Some are efficacious against both Gram-positive and Gram-negative bacteria and against drug-resistant strains as well. The mechanism of antibacterial action of a large number of the chemically identified antibacterial agents, possible synergism with currently used antibiotics, and the issue of possible toxicity on mammalian cells and tissues await elucidation. The structural characteristics pivotal to antibacterial activity have been ascertained in only a few studies. Demonstration of efficacy of the antibacterial agents in animal models of bacterial infection is highly desirable. Structural characterization of the active principles present in aqueous and organic extracts of marine organisms with reportedly antibacterial activity would be desirable.
AbstractList Marine organisms comprising microbes, plants, invertebrates, and vertebrates elaborate an impressive array of structurally diverse antimicrobial products ranging from small cyclic compounds to macromolecules such as proteins. Some of these biomolecules originate directly from marine animals while others arise from microbes associated with the animals. It is noteworthy that some of the biomolecules referred to above are structurally unique while others belong to known classes of compounds, peptides, and proteins. Some of the antibacterial agents are more active against Gram-positive bacteria while others have higher effectiveness on Gram-negative bacteria. Some are efficacious against both Gram-positive and Gram-negative bacteria and against drug-resistant strains as well. The mechanism of antibacterial action of a large number of the chemically identified antibacterial agents, possible synergism with currently used antibiotics, and the issue of possible toxicity on mammalian cells and tissues await elucidation. The structural characteristics pivotal to antibacterial activity have been ascertained in only a few studies. Demonstration of efficacy of the antibacterial agents in animal models of bacterial infection is highly desirable. Structural characterization of the active principles present in aqueous and organic extracts of marine organisms with reportedly antibacterial activity would be desirable.
Audience Academic
Author Cheung, Randy Chi Fai
Bekhit, Adnan A
Ng, Tzi Bun
Wong, Jack Ho
Bekhit, Alaa El-Din
Author_xml – sequence: 1
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  fullname: Bekhit, Adnan A
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  fullname: Bekhit, Alaa El-Din
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25874533$$D View this record in MEDLINE/PubMed
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Snippet Marine organisms comprising microbes, plants, invertebrates, and vertebrates elaborate an impressive array of structurally diverse antimicrobial products...
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SubjectTerms Analysis
Animal models
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - pharmacology
Anti-infective agents
Antibacterial activity
Antibacterial agents
antibacterial properties
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Aquatic animals
Aquatic Organisms - chemistry
Aquatic Organisms - metabolism
Bacteria
Bacteria - drug effects
Bacterial diseases
Bacterial infections
Biomedical and Life Sciences
Biomolecules
Biosynthesis
Biotechnology
Cancer
Cyclic compounds
Drug resistance
Effectiveness
Gram-negative bacteria
Gram-positive bacteria
Health aspects
invertebrates
Life Sciences
Mammalian cells
mammals
Marine animals
Marine biology
Marine organisms
Medical research
Microbial Genetics and Genomics
Microbial Sensitivity Tests
Microbiology
Microorganisms
Mini-Review
Natural products
Organisms
Peptides
Pharmaceutical industry
Proteins
Structural analysis
Studies
Synergism
Testing
tissues
Toxicity
Vertebrates
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Title Antibacterial products of marine organisms
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