Dynamic regulation of CTCF stability and sub-nuclear localization in response to stress

• Published in: PLoS genetics Vol. 17; no. 1; p. e1009277
• Main Authors: Lehman, Bettina J., Lopez-Diaz, Fernando J., Santisakultarm, Thom P., Fang, Linjing, Shokhirev, Maxim N., Diffenderfer, Kenneth E., Manor, Uri, Emerson, Beverly M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.01.2021; Public Library of Science (PLoS)
• Subjects: Binding Sites; Biology and Life Sciences; CCCTC-Binding Factor - genetics; Cell Differentiation; Cell Line, Tumor; Cell nuclei; Chromatin; Chromosomes; Control; DNA-Binding Proteins - genetics; Epigenesis, Genetic - genetics; Gene Expression Regulation; Genetic aspects; Genetic regulation; Genomics; Humans; Mammary Glands, Human - cytology; Mammary Glands, Human - metabolism; Medicine and Health Sciences; Methods; Neoplasms - genetics; Neoplasms - pathology; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - pathology; Neurons - metabolism; Neurons - pathology; Oxidative Stress - genetics; Physiological aspects; Pluripotent Stem Cells - metabolism; Pluripotent Stem Cells - pathology; Protein Binding; RNA Processing, Post-Transcriptional - genetics; Serine-Arginine Splicing Factors - genetics; Stress (Physiology); Stress, Physiological - genetics; Transcription factors

The nuclear protein CCCTC-binding factor (CTCF) has diverse roles in chromatin architecture and gene regulation. Functionally, CTCF associates with thousands of genomic sites and interacts with proteins, such as cohesin, or non-coding RNAs to facilitate specific transcriptional programming. In this...