Dynamic regulation of B cell complement signaling is integral to germinal center responses

• Published in: Nature Immunology Vol. 22; no. 6; pp. 757 - 768
• Main Authors: Cumpelik, Arun, Heja, David, Hu, Yuan, Varano, Gabriele, Ordikhani, Farideh, Roberto, Mark P., He, Zhengxiang, Homann, Dirk, Lira, Sergio A., Dominguez-Sola, David, Heeger, Peter S.
• Format: Journal Article
• Language: English
• Published: New York Springer Science and Business Media LLC 01.06.2021; Nature Publishing Group US; Nature Publishing Group
• Subjects: 631/250/2152/2153/1982; 631/250/2501; Affinity; Animals; Animals, B-Lymphocytes, CD55 Antigens, CD59 Antigens, Clonal Hematopoiesis, Lymphocyte Activation; Animals, Genetically Modified; Antigens; B cells; B-cell receptor; B-Lymphocytes; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Bcl-6 protein; Biomedical and Life Sciences; Biomedicine; CD40 antigen; CD55 Antigens; CD55 Antigens - genetics; CD55 Antigens - metabolism; CD59 antigen; CD59 Antigens; CD59 Antigens - metabolism; Cell activation; Cell Line, Tumor; Cellular signal transduction; Clonal Hematopoiesis; Clonal Hematopoiesis - immunology; Clonal selection; Complement (Immunology); Complement Activation; Complement C3a; Complement C3a - metabolism; Complement C5a; Complement C5a - metabolism; Complement component C3; Complement component C5a; Complement regulatory proteins; Decay-accelerating factor; Genetic aspects; Germinal Center; Germinal Center - cytology; Germinal Center - immunology; Germinal Center - metabolism; Germinal centers; Health aspects; Humans; Immunology; Infectious Diseases; Lymphocyte Activation; Lymphocytes B; Lymphocytes T; Lymphoid tissue; Membrane attack complex; Mice; Palatine Tonsil; Palatine Tonsil - cytology; Palatine Tonsil - pathology; Physiological aspects; Positive selection; Proto-Oncogene Proteins c-bcl-6; Proto-Oncogene Proteins c-bcl-6 - metabolism; Rapamycin; Receptor, Anaphylatoxin C5a; Receptor, Anaphylatoxin C5a - genetics; Receptor, Anaphylatoxin C5a - metabolism; Receptors, Antigen, B-Cell; Receptors, Antigen, B-Cell - metabolism; Receptors, Complement; Receptors, Complement - genetics; Receptors, Complement - metabolism; Signal Transduction; Signal Transduction - immunology; TOR protein; TOR Serine-Threonine Kinases; TOR Serine-Threonine Kinases - metabolism; Transcription factors; United States

Maturation of B cells within germinal centers (GCs) generates diversified B cell pools and high-affinity B cell antigen receptors (BCRs) for pathogen clearance. Increased receptor affinity is achieved by iterative cycles of T cell–dependent, affinity-based B cell positive selection and clonal expans...