The recombinant N-terminal domain of spike proteins is a potential vaccine against Middle East respiratory syndrome coronavirus (MERS-CoV) infection

• Published in: Vaccine Vol. 35; no. 1; pp. 10 - 18
• Main Authors: Jiaming, Lan, Yanfeng, Yao, Yao, Deng, Yawei, Hu, Linlin, Bao, Baoying, Huang, Jinghua, Yan, Gao, George F., Chuan, Qin, Wenjie, Tan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 03.01.2017; Elsevier Limited
• Subjects: adjuvants; Allergy and Immunology; Aluminum; Animal model; animal models; Animals; Antibodies, Neutralizing - blood; Antibodies, Viral - blood; Antigens; blood serum; cell-mediated immunity; Coronaviridae; Coronavirus Infections - prevention & control; cytokines; Disease Models, Animal; Enzymes; Female; Health risks; humans; humoral immunity; Immune response; Immunization; Immunoassay; Immunogenicity; immunoglobulin G; Immunoglobulin G - blood; Immunoglobulins; Infections; Laboratory animals; Lung - pathology; MERS-CoV; Mice; Mice, Inbred BALB C; Middle East respiratory syndrome coronavirus; Middle East Respiratory Syndrome Coronavirus - genetics; Middle East Respiratory Syndrome Coronavirus - immunology; neutralization; neutralizing antibodies; NTD; Proteins; Public health; R&D; RBD; Research & development; Respiratory diseases; Rodents; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; staining; Studies; T-lymphocytes; T-Lymphocytes - immunology; vaccination; Vaccine; Vaccines; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - genetics; Vaccines, Synthetic - immunology; Viral Vaccines - administration & dosage; Viral Vaccines - genetics; Viral Vaccines - immunology; Middle East; Animal model; MERS-CoV; Vaccine; Mice; RBD; NTD

The persistent public health threat of infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) highlights the need for an effective MERS-CoV vaccine. Previous studies have focused mainly on the receptor-binding domain (RBD) on the spike protein of MERS-CoV. Herein, we investigated...