Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals

• Published in: The Journal of clinical investigation Vol. 124; no. 7; pp. 3252 - 3262
• Main Authors: Kardava, Lela, Moir, Susan, Shah, Naisha, Wang, Wei, Wilson, Richard, Buckner, Clarisa M., Santich, Brian H., Kim, Leo J.Y., Spurlin, Emily E., Nelson, Amy K., Wheatley, Adam K., Harvey, Christopher J., McDermott, Adrian B., Wucherpfennig, Kai W., Chun, Tae-Wook, Tsang, John S., Li, Yuxing, Fauci, Anthony S.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.07.2014
• Subjects: Acquired immune deficiency syndrome; Acute Disease; AIDS; Anti-HIV Agents - therapeutic use; Antibodies, Neutralizing - blood; Antigens; B cells; B-Lymphocyte Subsets - immunology; B-Lymphocyte Subsets - metabolism; B-Lymphocyte Subsets - pathology; Binding sites; Biomedical research; Chronic Disease; env Gene Products, Human Immunodeficiency Virus - immunology; Gene expression; HIV; HIV Antibodies - blood; HIV Envelope Protein gp120 - immunology; HIV infection; HIV Infections - genetics; HIV Infections - immunology; HIV Infections - virology; Human immunodeficiency virus; Humans; Immune response; Immune system; Immunoglobulins; Immunologic Memory; Infections; Physiological aspects; Physiological research; Properties; Software; Statistical methods; Studies; Transcriptome; Viral Load

Recently, several neutralizing anti-HIV antibodies have been isolated from memory B cells of HIV-infected individuals. Despite extensive evidence of B cell dysfunction in HIV disease, little is known about the cells from which these rare HIV-specific antibodies originate. Accordingly, we used HIV en...