A Road Map for Those Who Don't Know JAK-STAT

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transmits information received from extracellular polypeptide signals, through transmembrane receptors, directly to target gene promoters in the nucleus, providing a mechanism for transcriptional regulation without...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 296; no. 5573; pp. 1653 - 1655
Main Authors Aaronson, David S., Horvath, Curt M.
Format Journal Article
LanguageEnglish
Published United States American Society for the Advancement of Science 31.05.2002
American Association for the Advancement of Science
The American Association for the Advancement of Science
Subjects
Animals
Cancer
Cancer research
Cell cycle proteins
Cells
Cellular biology
Cytokines
Cytokines - metabolism
Dimerization
Dimers
DNA
DNA-Binding Proteins - chemistry
DNA-Binding Proteins - metabolism
Evaluation
Gene expression regulation
Genes
Genetic research
Humans
Inhibition
Integrins
Interferon Type I - metabolism
Interferon-gamma - metabolism
Jak kinase
Janus Kinase 1
Mammals
Membranes
Models, Biological
Oncology, Experimental
Peptides
Phosphorylation
Protein-Tyrosine Kinases - chemistry
Protein-Tyrosine Kinases - metabolism
Proteins
Receptors
Signal Transduction
Stat protein
STAT3 Transcription Factor
Stimuli
Trans-Activators - chemistry
Trans-Activators - metabolism
Transcription, Genetic
Tyrosine metabolism
Viewpoints and Connections Maps
United States
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Summary:The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transmits information received from extracellular polypeptide signals, through transmembrane receptors, directly to target gene promoters in the nucleus, providing a mechanism for transcriptional regulation without second messengers. Evolutionarily conserved in eukaryotic organisms from slime molds to humans, JAK-STAT signaling appears to be an early adaptation to facilitate intercellular communication that has co-evolved with myriad cellular signaling events. This co-evolution has given rise to highly adapted, ligand-specific signaling pathways that control gene expression. In addition, the JAK-STAT signaling pathways are regulated by a vast array of intrinsic and environmental stimuli, which can add plasticity to the response of a cell or tissue.
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.1071545