Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation

• Published in: Mediators of inflammation Vol. 2019; no. 2019; pp. 1 - 14
• Main Authors: Cunha, Fernando Queiroz, Casagrande, Rúbia, Verri, Waldiceu A., Alves-Filho, José C., Bernardy, Catia C. F., Zaninelli, Tiago H., Borghi, Sergio M., Rossaneis, Ana C., Domiciano, Talita P., Fattori, Victor, Lourenco-Gonzalez, Yuri, Cunha, Thiago Mattar
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2019; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Abdomen; Analgesics; Analysis; Anti-inflammatory drugs; Antioxidants; Arthritis; Care and treatment; Central nervous system agents; Cognitive enhancement; Disease; Drug development; Drug dosages; Edema; Experiments; Gene expression; Hyperalgesia; IL-1β; Immunology; Inflammation; Kidneys; Neurons; Neutrophils; NF-κB protein; Nonsteroidal anti-inflammatory drugs; Oxidation; Pain; Pain perception; Peritoneum; Potassium; Reactive oxygen species; Scientific equipment and supplies industry; Skin; Superoxide; Tumor necrosis factor-α; Vinpocetine; Brazil; United States; United States > US

Clinically active drugs for the treatment of acute pain have their prescription limited due to the significant side effects they induce. An increase in reactive oxygen species (ROS) has been linked to several conditions, including inflammation and pain processing. Therefore, new or repurposed drugs...