Transcriptional Dysregulation in NIPBL and Cohesin Mutant Human Cells

• Published in: PLoS biology Vol. 7; no. 5; p. e1000119
• Main Authors: Liu, Jinglan, Zhang, Zhe, Bando, Masashige, Itoh, Takehiko, Deardorff, Matthew A., Clark, Dinah, Kaur, Maninder, Tandy, Stephany, Kondoh, Tatsuro, Rappaport, Eric, Spinner, Nancy B., Vega, Hugo, Jackson, Laird G., Shirahige, Katsuhiko, Krantz, Ian D.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.05.2009; Public Library of Science (PLoS)
• Subjects: Analysis; Binding sites; Cell Biology/Gene Expression; Cell cycle; Cell Cycle Proteins - genetics; Chondroitin Sulfate Proteoglycans - genetics; Chromatin Immunoprecipitation; Chromosomal Proteins, Non-Histone - genetics; Databases, Genetic; De Lange Syndrome - genetics; Developmental Biology/Developmental Molecular Mechanisms; Developmental Biology/Molecular Development; Gene Expression Regulation; Genetic transcription; Genetics; Genetics and Genomics/Chromosome Biology; Genetics and Genomics/Epigenetics; Genetics and Genomics/Gene Expression; Genetics and Genomics/Genetics of Disease; Genetics and Genomics/Genomics; Genetics and Genomics/Medical Genetics; Genomes; Human cell culture; Oligonucleotide Array Sequence Analysis; Pediatrics and Child Health/Child Development; Polymerase Chain Reaction; Promoter Regions, Genetic - genetics; Proteins; Proteins - genetics; United States; Proteins; Promoter Regions, Genetic; Chromatin Immunoprecipitation; Oligonucleotide Array Sequence Analysis; Chromosomal Proteins, Non-Histone; Gene Expression Regulation; Polymerase Chain Reaction; Databases, Genetic; De Lange Syndrome; Cell Cycle Proteins; Chondroitin Sulfate Proteoglycans

Cohesin regulates sister chromatid cohesion during the mitotic cell cycle with Nipped-B-Like (NIPBL) facilitating its loading and unloading. In addition to this canonical role, cohesin has also been demonstrated to play a critical role in regulation of gene expression in nondividing cells. Heterozyg...