Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes

• Published in: The Journal of clinical investigation Vol. 127; no. 6; pp. 2133 - 2147
• Main Authors: Kraakman, Michael J., Lee, Man K.S., Al-Sharea, Annas, Dragoljevic, Dragana, Barrett, Tessa J., Montenont, Emilie, Basu, Debapriya, Heywood, Sarah, Kammoun, Helene L., Flynn, Michelle, Whillas, Alexandra, Hanssen, Nordin M.J., Febbraio, Mark A., Westein, Erik, Fisher, Edward A., Chin-Dusting, Jaye, Cooper, Mark E., Berger, Jeffrey S., Goldberg, Ira J., Nagareddy, Prabhakara R., Murphy, Andrew J.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.06.2017
• Subjects: Advanced glycosylation end products; Animals; Antiplatelet therapy; Atherogenesis; Atherosclerosis; Atherosclerosis - immunology; Atherosclerosis - metabolism; Biomedical research; Blood platelets; Blood Platelets - physiology; Bone marrow; Calcium; Calcium binding proteins; Calgranulin A - physiology; Calgranulin B - physiology; Cardiovascular disease; Cardiovascular diseases; Cell proliferation; Chemokines; Complications and side effects; Cytokines; Development and progression; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - immunology; Diabetes Mellitus, Experimental - metabolism; Glucose; Glycosylation; Health aspects; Hemoglobin; Hepatocytes; Humans; Hyperglycemia; Inflammation; Interleukin 6; Ischemia; Kupffer cells; Leukocytes (neutrophilic); Lupus; Male; Megakaryocytes; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Mortality; Myocardial ischemia; Na+/glucose cotransporter; Neutrophils; Neutrophils - metabolism; Osteoprogenitor cells; Platelets; Proteins; Rodents; Sodium; Stem cells; Thrombocytosis; Thrombocytosis - immunology; Thrombocytosis - metabolism; Thrombosis

Platelets play a critical role in atherogenesis and thrombosis-mediated myocardial ischemia, processes that are accelerated in diabetes. Whether hyperglycemia promotes platelet production and whether enhanced platelet production contributes to enhanced atherothrombosis remains unknown. Here we found...