Mannose-binding lectin and mannose-binding lectin–associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults

• Published in: Journal of allergy and clinical immunology Vol. 122; no. 2; pp. 368 - 374.e2
• Main Authors: Garcia-Laorden, M. Isabel, BSc, Sole-Violan, Jordi, PhD, de Castro, Felipe Rodriguez, PhD, Aspa, Javier, PhD, Briones, M. Luisa, PhD, Garcia-Saavedra, Ayoze, BSc, Rajas, Olga, PhD, Blanquer, Jose, PhD, Caballero-Hidalgo, Araceli, BEc, Marcos-Ramos, J. Alberto, MD, Hernandez-Lopez, Javier, BSc, Rodriguez-Gallego, Carlos, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.08.2008; Elsevier; Elsevier Limited
• Subjects: Adult; Aged; Alleles; Allergy and Immunology; Biological and medical sciences; Case-Control Studies; Chronic obstructive pulmonary disease; Community-Acquired Infections - genetics; Community-acquired pneumonia; Drug therapy; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Kaplan-Meier Estimate; Male; mannose-binding lectin; Mannose-Binding Lectin - blood; Mannose-Binding Lectin - deficiency; Mannose-Binding Lectin - genetics; Mannose-Binding Lectin - physiology; mannose-binding lectin–associated serine protease 2; Mannose-Binding Protein-Associated Serine Proteases - analysis; Mannose-Binding Protein-Associated Serine Proteases - deficiency; Mannose-Binding Protein-Associated Serine Proteases - genetics; Medical sciences; Middle Aged; Mortality; Pneumonia; Pneumonia, Bacterial - genetics; Pneumonia, Bacterial - metabolism; Pneumonia, Bacterial - physiopathology; Pneumonia, Pneumococcal - genetics; Pneumonia, Pneumococcal - metabolism; Pneumonia, Pneumococcal - physiopathology; Polymorphism, Genetic; primary immunodeficiency; Prospective Studies; Respiratory distress syndrome; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; sepsis; Severity of Illness Index; Acute respiratory distress syndrome; LP; Severe sepsis; SSh; Intensive care unit; MODS; Mannose-binding lectin serine protease 2; MBL; primary immunodeficiency; ARDS; SS; OR; Lectin pathway; Multiple organ dysfunction syndrome; Septic shock; Community-acquired pneumonia; Peptidoglycan; CAP; ARF; MASP-2; PGN; Acute respiratory failure; Odds ratio; ICU; sepsis; mannose-binding lectin; mannose-binding lectin–associated serine protease 2; Pneumonia; Prognosis; Mannose binding lectin; mannose-binding lectin-associated serine protease 2; mannose- binding lectin; Sepsis syndrome; Immunology; Primary; Adult; Evolution; Human; Lung disease; Immunopathology; Serine endopeptidases; Enzyme; Respiratory disease; Severity; Immune deficiency; Bacteremia; Infection; Peptidases; Sensitivity; Community acquired infection; Bacteriosis; Hydrolases

Background Community-acquired pneumonia (CAP) is the leading cause of death from infection in developed countries. Mannose-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) deficiencies are common primary immunodeficiencies the clinical penetrance of which remains controversial. MBL...