Hematological and gene co-expression network analyses of high-risk beef cattle defines immunological mechanisms and biological complexes involved in bovine respiratory disease and weight gain

• Published in: PloS one Vol. 17; no. 11; p. e0277033
• Main Authors: Scott, Matthew A., Woolums, Amelia R., Swiderski, Cyprianna E., Finley, Abigail, Perkins, Andy D., Nanduri, Bindu, Karisch, Brandi B.
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 03.11.2022; Public Library of Science (PLoS)
• Subjects: Analysis; Beef; Beef cattle; Biomarkers; Blood; Bovine respiratory disease complex; Care and treatment; Cattle; Cattle production; Clustering; Connectivity; Correlation; Diagnosis; Diseases; Eosinophils; Erythrocytes; Gene expression; Gene set enrichment analysis; Genes; Genetic aspects; Growth; Hematology; Hemoglobin; Immunology; Leukocytes (eosinophilic); Lymphocytes T; Metabolism; Mitochondria; Modules; Network analysis; Neutrophils; Preservation; Proteins; Respiratory diseases; Ribonucleic acid; RNA; RNA sequencing; rRNA; United States; United States > US; Mississippi

Bovine respiratory disease (BRD), the leading disease complex in beef cattle production systems, remains highly elusive regarding diagnostics and disease prediction. Previous research has employed cellular and molecular techniques to describe hematological and gene expression variation that coincide...