Association between nitric oxide synthase T-786C genetic polymorphism and chronic kidney disease: Meta-analysis incorporating trial sequential analysis

• Published in: PloS one Vol. 16; no. 10; p. e0258789
• Main Authors: Hsiao, Po-Jen, Chiu, Chih-Chien, Tsai, Dung-Jang, Ko, Pi-Shao, Chen, Ying-Kai, Cheng, Hao, Su, Wen, Lu, Kuo-Cheng, Su, Sui-Lung
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 18.10.2021; Public Library of Science (PLoS)
• Subjects: Analysis; Armed forces; Biology and Life Sciences; Chronic kidney failure; Confidence intervals; Diabetes; Dialysis; Functional analysis; Gene expression; Gene polymorphism; Genetic aspects; Genetic polymorphisms; Glomerular filtration rate; Hemodialysis; Hospitals; Hypertension; Internal medicine; Kidney diseases; Kidneys; Life sciences; Medicine; Medicine and Health Sciences; Meta-analysis; Nephrology; Nitric oxide; Nitric-oxide synthase; Physical Sciences; Polymorphism; Public health; Research and Analysis Methods; Sample size; Sequential analysis; Taiwan

Several meta-analyses of the relationship between endothelial nitric oxide synthase (eNOS) T-786C gene polymorphism and chronic kidney disease (CKD) have been published. However, the results of these studies were inconsistent, and it is undetermined whether sample sizes are sufficient to reach a def...