Plasma microRNAs biomarkers in mild cognitive impairment among patients with type 2 diabetes mellitus

To assess the potential value of some miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI) among patients with type2 diabetes mellitus (T2DM) and to identify other risk factors for MCI among them. This study enrolled 163 adults with T2DM using face to face interview. Cognitive functio...

Full description

Saved in:
Bibliographic Details
Published inPloS one Vol. 15; no. 7; p. e0236453
Main Authors Salama, Iman I., Sami, Samia M., Abdellatif, Ghada A., Mohsen, Amira, Rasmy, Hanaa, Kamel, Solaf Ahmed, Ibrahim, Mona Hamed, Mostafa, Mona, Fouad, Walaa A., Raslan, Hala M.
Format Journal Article
LanguageEnglish
Published San Francisco Public Library of Science 29.07.2020
Public Library of Science (PLoS)
Subjects
Alzheimer's disease
Biology and Life Sciences
Biomarkers
Blood plasma
Blood pressure
Cognition
Cognition & reasoning
Cognitive ability
Cognitive disorders
Complications and side effects
Dementia
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diagnosis
Diagnostic systems
Disease
Drugs
Education
Gender
Gene expression
Genetic aspects
Health aspects
Hemoglobin
Hypertension
Identification methods
Impairment
Internal medicine
Lipids
Medicine
Medicine and Health Sciences
MicroRNA
MicroRNAs
miRNA
Pathology
Plasma
Quality of life
Regression analysis
Risk analysis
Risk factors
Sensitivity
Type 2 diabetes
Egypt
Cairo Egypt
United States > US
Germany
Online AccessGet full text

Cover

Abstract To assess the potential value of some miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI) among patients with type2 diabetes mellitus (T2DM) and to identify other risk factors for MCI among them. This study enrolled 163 adults with T2DM using face to face interview. Cognitive function with its domains was assessed using Adenbrooke's Cognitive Examination III (ACE III). Lipid profile, glycated hemoglobin, and miR-128, miR-132, miR- 874, miR-134, miR-323, and miR-382 expressions, using quantitative real-time PCR, were assessed. MCI was detected among 59/163 (36.2%) patients with T2DM. Plasma expression of miR-132 was significantly higher in T2DM patients with MCI compared to those without MCI and to normal cognitive healthy individuals (median = 2, 1.1 and 1.2 respectively, P < 0.05. Logistic regression analysis showed that higher miR-132 expression with adjusted odds ratio (AOR): 1.2 (95% CI 1.0-1.3), female gender (AOR:2.1; 95%CI 1.0-4.3), education below postgraduate (secondary and university education with AOR: 9.5 & 19.4 respectively) were the significant predicting factors for MCI among T2DM patients. Using ROC curve, miR-132 was the only assayed miRNA that significantly differentiates T2DM patients with MCI from those with normal cognition with 72.3% sensitivity, 56.2% specificity, and 63.8% accuracy (P < 0.05). Other studied miRNAs showed lower sensitivity and specificity for detecting MCI among studied T2DM participants. MCI affects nearly one-third of adult patients with T2DM. A significantly over expression of miR-132 was detected among T2DM with MCI compared to those with normal cognition.
AbstractList Objectives To assess the potential value of some miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI) among patients with type2 diabetes mellitus (T2DM) and to identify other risk factors for MCI among them. Methods This study enrolled 163 adults with T2DM using face to face interview. Cognitive function with its domains was assessed using Adenbrooke’s Cognitive Examination III (ACE III). Lipid profile, glycated hemoglobin, and miR-128, miR-132, miR- 874, miR-134, miR-323, and miR-382 expressions, using quantitative real-time PCR, were assessed. Results MCI was detected among 59/163 (36.2%) patients with T2DM. Plasma expression of miR-132 was significantly higher in T2DM patients with MCI compared to those without MCI and to normal cognitive healthy individuals (median = 2, 1.1 and 1.2 respectively, P < 0.05. Logistic regression analysis showed that higher miR-132 expression with adjusted odds ratio (AOR): 1.2 (95% CI 1.0–1.3), female gender (AOR:2.1; 95%CI 1.0–4.3), education below postgraduate (secondary and university education with AOR: 9.5 & 19.4 respectively) were the significant predicting factors for MCI among T2DM patients. Using ROC curve, miR-132 was the only assayed miRNA that significantly differentiates T2DM patients with MCI from those with normal cognition with 72.3% sensitivity, 56.2% specificity, and 63.8% accuracy (P < 0.05). Other studied miRNAs showed lower sensitivity and specificity for detecting MCI among studied T2DM participants. Conclusion MCI affects nearly one-third of adult patients with T2DM. A significantly over expression of miR-132 was detected among T2DM with MCI compared to those with normal cognition.
To assess the potential value of some miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI) among patients with type2 diabetes mellitus (T2DM) and to identify other risk factors for MCI among them. This study enrolled 163 adults with T2DM using face to face interview. Cognitive function with its domains was assessed using Adenbrooke's Cognitive Examination III (ACE III). Lipid profile, glycated hemoglobin, and miR-128, miR-132, miR- 874, miR-134, miR-323, and miR-382 expressions, using quantitative real-time PCR, were assessed. MCI was detected among 59/163 (36.2%) patients with T2DM. Plasma expression of miR-132 was significantly higher in T2DM patients with MCI compared to those without MCI and to normal cognitive healthy individuals (median = 2, 1.1 and 1.2 respectively, P < 0.05. Logistic regression analysis showed that higher miR-132 expression with adjusted odds ratio (AOR): 1.2 (95% CI 1.0-1.3), female gender (AOR:2.1; 95%CI 1.0-4.3), education below postgraduate (secondary and university education with AOR: 9.5 & 19.4 respectively) were the significant predicting factors for MCI among T2DM patients. Using ROC curve, miR-132 was the only assayed miRNA that significantly differentiates T2DM patients with MCI from those with normal cognition with 72.3% sensitivity, 56.2% specificity, and 63.8% accuracy (P < 0.05). Other studied miRNAs showed lower sensitivity and specificity for detecting MCI among studied T2DM participants. MCI affects nearly one-third of adult patients with T2DM. A significantly over expression of miR-132 was detected among T2DM with MCI compared to those with normal cognition.
ObjectivesTo assess the potential value of some miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI) among patients with type2 diabetes mellitus (T2DM) and to identify other risk factors for MCI among them.MethodsThis study enrolled 163 adults with T2DM using face to face interview. Cognitive function with its domains was assessed using Adenbrooke's Cognitive Examination III (ACE III). Lipid profile, glycated hemoglobin, and miR-128, miR-132, miR- 874, miR-134, miR-323, and miR-382 expressions, using quantitative real-time PCR, were assessed.ResultsMCI was detected among 59/163 (36.2%) patients with T2DM. Plasma expression of miR-132 was significantly higher in T2DM patients with MCI compared to those without MCI and to normal cognitive healthy individuals (median = 2, 1.1 and 1.2 respectively, P < 0.05. Logistic regression analysis showed that higher miR-132 expression with adjusted odds ratio (AOR): 1.2 (95% CI 1.0-1.3), female gender (AOR:2.1; 95%CI 1.0-4.3), education below postgraduate (secondary and university education with AOR: 9.5 & 19.4 respectively) were the significant predicting factors for MCI among T2DM patients. Using ROC curve, miR-132 was the only assayed miRNA that significantly differentiates T2DM patients with MCI from those with normal cognition with 72.3% sensitivity, 56.2% specificity, and 63.8% accuracy (P < 0.05). Other studied miRNAs showed lower sensitivity and specificity for detecting MCI among studied T2DM participants.ConclusionMCI affects nearly one-third of adult patients with T2DM. A significantly over expression of miR-132 was detected among T2DM with MCI compared to those with normal cognition.
Objectives To assess the potential value of some miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI) among patients with type2 diabetes mellitus (T2DM) and to identify other risk factors for MCI among them. Methods This study enrolled 163 adults with T2DM using face to face interview. Cognitive function with its domains was assessed using Adenbrooke’s Cognitive Examination III (ACE III). Lipid profile, glycated hemoglobin, and miR-128, miR-132, miR- 874, miR-134, miR-323, and miR-382 expressions, using quantitative real-time PCR, were assessed. Results MCI was detected among 59/163 (36.2%) patients with T2DM. Plasma expression of miR-132 was significantly higher in T2DM patients with MCI compared to those without MCI and to normal cognitive healthy individuals (median = 2, 1.1 and 1.2 respectively, P < 0.05. Logistic regression analysis showed that higher miR-132 expression with adjusted odds ratio (AOR): 1.2 (95% CI 1.0–1.3), female gender (AOR:2.1; 95%CI 1.0–4.3), education below postgraduate (secondary and university education with AOR: 9.5 & 19.4 respectively) were the significant predicting factors for MCI among T2DM patients. Using ROC curve, miR-132 was the only assayed miRNA that significantly differentiates T2DM patients with MCI from those with normal cognition with 72.3% sensitivity, 56.2% specificity, and 63.8% accuracy (P < 0.05). Other studied miRNAs showed lower sensitivity and specificity for detecting MCI among studied T2DM participants. Conclusion MCI affects nearly one-third of adult patients with T2DM. A significantly over expression of miR-132 was detected among T2DM with MCI compared to those with normal cognition.
To assess the potential value of some miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI) among patients with type2 diabetes mellitus (T2DM) and to identify other risk factors for MCI among them.OBJECTIVESTo assess the potential value of some miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI) among patients with type2 diabetes mellitus (T2DM) and to identify other risk factors for MCI among them.This study enrolled 163 adults with T2DM using face to face interview. Cognitive function with its domains was assessed using Adenbrooke's Cognitive Examination III (ACE III). Lipid profile, glycated hemoglobin, and miR-128, miR-132, miR- 874, miR-134, miR-323, and miR-382 expressions, using quantitative real-time PCR, were assessed.METHODSThis study enrolled 163 adults with T2DM using face to face interview. Cognitive function with its domains was assessed using Adenbrooke's Cognitive Examination III (ACE III). Lipid profile, glycated hemoglobin, and miR-128, miR-132, miR- 874, miR-134, miR-323, and miR-382 expressions, using quantitative real-time PCR, were assessed.MCI was detected among 59/163 (36.2%) patients with T2DM. Plasma expression of miR-132 was significantly higher in T2DM patients with MCI compared to those without MCI and to normal cognitive healthy individuals (median = 2, 1.1 and 1.2 respectively, P < 0.05. Logistic regression analysis showed that higher miR-132 expression with adjusted odds ratio (AOR): 1.2 (95% CI 1.0-1.3), female gender (AOR:2.1; 95%CI 1.0-4.3), education below postgraduate (secondary and university education with AOR: 9.5 & 19.4 respectively) were the significant predicting factors for MCI among T2DM patients. Using ROC curve, miR-132 was the only assayed miRNA that significantly differentiates T2DM patients with MCI from those with normal cognition with 72.3% sensitivity, 56.2% specificity, and 63.8% accuracy (P < 0.05). Other studied miRNAs showed lower sensitivity and specificity for detecting MCI among studied T2DM participants.RESULTSMCI was detected among 59/163 (36.2%) patients with T2DM. Plasma expression of miR-132 was significantly higher in T2DM patients with MCI compared to those without MCI and to normal cognitive healthy individuals (median = 2, 1.1 and 1.2 respectively, P < 0.05. Logistic regression analysis showed that higher miR-132 expression with adjusted odds ratio (AOR): 1.2 (95% CI 1.0-1.3), female gender (AOR:2.1; 95%CI 1.0-4.3), education below postgraduate (secondary and university education with AOR: 9.5 & 19.4 respectively) were the significant predicting factors for MCI among T2DM patients. Using ROC curve, miR-132 was the only assayed miRNA that significantly differentiates T2DM patients with MCI from those with normal cognition with 72.3% sensitivity, 56.2% specificity, and 63.8% accuracy (P < 0.05). Other studied miRNAs showed lower sensitivity and specificity for detecting MCI among studied T2DM participants.MCI affects nearly one-third of adult patients with T2DM. A significantly over expression of miR-132 was detected among T2DM with MCI compared to those with normal cognition.CONCLUSIONMCI affects nearly one-third of adult patients with T2DM. A significantly over expression of miR-132 was detected among T2DM with MCI compared to those with normal cognition.
Audience Academic
Author Mostafa, Mona
Fouad, Walaa A.
Kamel, Solaf Ahmed
Sami, Samia M.
Salama, Iman I.
Mohsen, Amira
Raslan, Hala M.
Abdellatif, Ghada A.
Ibrahim, Mona Hamed
Rasmy, Hanaa
AuthorAffiliation 2 Child Health Department, National Research Centre, Cairo, Egypt
Nathan S Kline Institute, UNITED STATES
3 Clinical and Chemical Pathology Department, Centre of Excellence, National Research Centre, Cairo, Egypt
1 Community Medicine Department, National Research Centre, Cairo, Egypt
4 Internal Medicine Department, National Research Centre, Cairo, Egypt
AuthorAffiliation_xml – name: 3 Clinical and Chemical Pathology Department, Centre of Excellence, National Research Centre, Cairo, Egypt
– name: 4 Internal Medicine Department, National Research Centre, Cairo, Egypt
– name: Nathan S Kline Institute, UNITED STATES
– name: 1 Community Medicine Department, National Research Centre, Cairo, Egypt
– name: 2 Child Health Department, National Research Centre, Cairo, Egypt
Author_xml – sequence: 1
  givenname: Iman I.
  orcidid: 0000-0001-8901-4625
  surname: Salama
  fullname: Salama, Iman I.
– sequence: 2
  givenname: Samia M.
  surname: Sami
  fullname: Sami, Samia M.
– sequence: 3
  givenname: Ghada A.
  surname: Abdellatif
  fullname: Abdellatif, Ghada A.
– sequence: 4
  givenname: Amira
  surname: Mohsen
  fullname: Mohsen, Amira
– sequence: 5
  givenname: Hanaa
  surname: Rasmy
  fullname: Rasmy, Hanaa
– sequence: 6
  givenname: Solaf Ahmed
  surname: Kamel
  fullname: Kamel, Solaf Ahmed
– sequence: 7
  givenname: Mona Hamed
  surname: Ibrahim
  fullname: Ibrahim, Mona Hamed
– sequence: 8
  givenname: Mona
  surname: Mostafa
  fullname: Mostafa, Mona
– sequence: 9
  givenname: Walaa A.
  surname: Fouad
  fullname: Fouad, Walaa A.
– sequence: 10
  givenname: Hala M.
  surname: Raslan
  fullname: Raslan, Hala M.
BookMark eNqNk9tq3DAQhk1JaQ7tGxQqKJT2Yrc6WLKdi8ISelgITUkPt0KWZa-2suVactq8fWezDsQhlOILj8bf_KMZzxwnB53vTJI8J3hJWEbebv04dMote3AvMWUi5exRckQKRheCYnZwxz5MjkPYYsxZLsST5JDRjApGi6PEfHEqtAq1Vg_-8vMqoNL6Vg0_zRCQ7cDvKqR909lorwyyba_s0JouItX6rkG9ihZOAf22cYPidW8QRZVVpYkmoNY4Z-MYniaPa-WCeTa9T5LvH95_O_u0OL_4uD5bnS-0EEVcqCxVouIF4RxjbTQpKqxqhlmeldjUlda5Mqnmua7LqswJ4cykpc44E3VFhWAnyYu9bu98kFOHgqQpzVOC05QCsd4TlVdb2Q8War2WXll54_BDI9UQrXZGMgioBc6xAovQvCxSXGQ8B4uXFc1A692UbSxbU2now6DcTHT-pbMb2fgrmbECM05A4PUkMPhfowlRtjZo6JnqjB9v7l1gnkJGQF_eQx-ubqIaBQXYrvaQV-9E5UowXLA85Ryo5QMUPJWBMYBxqi34ZwFvZgHARPMnNmoMQa6_Xv4_e_Fjzr66w26McnETvBuj9V2Yg6d7EIY0hMHUUtuodhjc3DpJsNztxG1P5G4n5LQTEJzeC779Q_8M-ws5IRDn
CitedBy_id crossref_primary_10_1038_s41598_022_21045_2
crossref_primary_10_12998_wjcc_v12_i3_525
crossref_primary_10_1111_1753_0407_13456
crossref_primary_10_1007_s00210_021_02154_7
crossref_primary_10_2144_fsoa_2022_0060
crossref_primary_10_4254_wjh_v14_i6_1053
crossref_primary_10_1371_journal_pone_0243177
crossref_primary_10_1186_s13098_021_00772_y
crossref_primary_10_3390_ijms23116144
crossref_primary_10_2298_VSP221107099L
crossref_primary_10_3233_JAD_215589
crossref_primary_10_1016_j_brainres_2024_148791
Cites_doi 10.1212/WNL.52.5.971
10.1016/j.neurobiolaging.2005.01.004
10.3389/fphar.2017.00770
10.3349/ymj.2018.59.9.1096
10.1371/journal.pone.0069807
10.2967/jnumed.113.132647
10.1016/j.neurobiolaging.2013.07.005
10.1371/journal.pone.0182932
10.3889/oamjms.2019.834
10.1038/s41574-018-0048-7
10.1016/j.diabres.2008.08.020
10.1016/j.diabres.2015.05.019
10.1038/nn.3599
10.1038/nature04367
10.18632/aging.100624
10.1038/s41598-018-20959-0
10.1002/emmm.201201974
10.1007/s12035-016-0365-6
10.1016/j.arr.2018.11.005
10.18632/aging.100486
10.1007/s00401-010-0756-0
10.3889/oamjms.2020.4245
10.1101/lm.039578.115
10.1001/jamainternmed.2013.13656
10.1371/journal.pone.0055064
10.3389/fnagi.2016.00017
10.1016/j.neuropharm.2014.01.026
10.1038/nature09271
10.1155/2014/862473
10.3389/fnagi.2017.00323
10.1007/s00429-012-0431-4
10.1093/occmed/kqv041
10.3945/ajcn.115.111872
10.1007/s11055-017-0427-x
10.3233/JAD-142847
10.1080/15548627.2016.1159375
10.1136/jnnp-2014-310095
10.3390/ijerph120708281
10.3389/fncel.2015.00191
10.1007/s00401-018-1880-5
10.1186/s13195-015-0130-5
10.1515/revneuro-2017-0016
10.3389/fphar.2019.00665
10.1111/acel.13046
10.1016/j.brainres.2011.12.001
10.2147/NDT.S189905
10.1038/s41467-018-04445-9
10.1016/j.neurobiolaging.2016.09.019
10.1016/j.neurobiolaging.2005.08.021
10.1517/14728222.2014.855201
10.3109/1354750X.2013.814073
ContentType Journal Article
Copyright COPYRIGHT 2020 Public Library of Science
2020 Salama et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2020 Salama et al 2020 Salama et al
Copyright_xml – notice: COPYRIGHT 2020 Public Library of Science
– notice: 2020 Salama et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2020 Salama et al 2020 Salama et al
DBID AAYXX
CITATION
IOV
ISR
3V.
7QG
7QL
7QO
7RV
7SN
7SS
7T5
7TG
7TM
7U9
7X2
7X7
7XB
88E
8AO
8C1
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABJCF
ABUWG
AEUYN
AFKRA
ARAPS
ATCPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
D1I
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
KB.
KB0
KL.
L6V
LK8
M0K
M0S
M1P
M7N
M7P
M7S
NAPCQ
P5Z
P62
P64
PATMY
PDBOC
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PTHSS
PYCSY
RC3
7X8
5PM
DOA
DOI 10.1371/journal.pone.0236453
DatabaseName CrossRef
Gale In Context: Opposing Viewpoints
Gale In Context: Science
ProQuest Central (Corporate)
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Biotechnology Research Abstracts
Nursing & Allied Health Database
Ecology Abstracts
Entomology Abstracts (Full archive)
Immunology Abstracts
Meteorological & Geoastrophysical Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Agricultural Science Collection
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Materials Science & Engineering Collection
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
ProQuest Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One
ProQuest Materials Science Collection
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Materials Science Database
Nursing & Allied Health Database (Alumni Edition)
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest Engineering Collection
Biological Sciences
Agriculture Science Database
Health & Medical Collection (Alumni)
Medical Database
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Engineering Database
Nursing & Allied Health Premium
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Environmental Science Database
Materials Science Collection
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
Engineering Collection
Environmental Science Collection
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
Agricultural Science Database
Publicly Available Content Database
ProQuest Central Student
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Meteorological & Geoastrophysical Abstracts
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Engineering Collection
Advanced Technologies & Aerospace Collection
Engineering Database
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Agricultural Science Collection
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
Entomology Abstracts
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Environmental Science Database
ProQuest Nursing & Allied Health Source (Alumni)
Engineering Research Database
ProQuest One Academic
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
ProQuest Engineering Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Agricultural & Environmental Science Collection
AIDS and Cancer Research Abstracts
Materials Science Database
ProQuest Materials Science Collection
ProQuest Public Health
ProQuest Nursing & Allied Health Source
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Animal Behavior Abstracts
Materials Science & Engineering Collection
Immunology Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Agricultural Science Database





MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
Medicine
Education
DocumentTitleAlternate Plasma microRNAs biomarkers in MCI among patients with T2DM
EISSN 1932-6203
ExternalDocumentID 2428410442
oai_doaj_org_article_3044f6080a304128b940975828b5bd27
PMC7390351
A630938455
10_1371_journal_pone_0236453
GeographicLocations Egypt
Cairo Egypt
United States--US
Germany
GeographicLocations_xml – name: Egypt
– name: Cairo Egypt
– name: Germany
– name: United States--US
GrantInformation_xml – fundername: ;
  grantid: 15026 and 4880
GroupedDBID ---
123
29O
2WC
53G
5VS
7RV
7X2
7X7
7XC
88E
8AO
8C1
8CJ
8FE
8FG
8FH
8FI
8FJ
A8Z
AAFWJ
AAUCC
AAWOE
AAYXX
ABDBF
ABIVO
ABJCF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ACUHS
ADBBV
AEAQA
AENEX
AEUYN
AFKRA
AFPKN
AFRAH
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
APEBS
ARAPS
ATCPS
BAWUL
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BKEYQ
BPHCQ
BVXVI
BWKFM
CCPQU
CITATION
CS3
D1I
D1J
D1K
DIK
DU5
E3Z
EAP
EAS
EBD
EMOBN
ESX
EX3
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
IAO
IEA
IGS
IHR
IHW
INH
INR
IOV
IPY
ISE
ISR
ITC
K6-
KB.
KQ8
L6V
LK5
LK8
M0K
M1P
M48
M7P
M7R
M7S
M~E
NAPCQ
O5R
O5S
OK1
OVT
P2P
P62
PATMY
PDBOC
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
PTHSS
PV9
PYCSY
RNS
RPM
RZL
SV3
TR2
UKHRP
WOQ
WOW
~02
~KM
BBORY
PMFND
3V.
7QG
7QL
7QO
7SN
7SS
7T5
7TG
7TM
7U9
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
KL.
M7N
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
RC3
7X8
5PM
PUEGO
AAPBV
ABPTK
ESTFP
ID FETCH-LOGICAL-c669t-a74a6d5915500cec19d0af30387b0efdcc8ae4c58cfbdb81153e4bc7536fd2663
IEDL.DBID M48
ISSN 1932-6203
IngestDate Sun Nov 05 00:20:32 EDT 2023
Wed Aug 27 01:21:11 EDT 2025
Thu Aug 21 14:25:29 EDT 2025
Mon Jul 21 10:15:25 EDT 2025
Fri Jul 25 11:23:44 EDT 2025
Tue Jun 17 20:55:34 EDT 2025
Tue Jun 10 20:29:21 EDT 2025
Fri Jun 27 03:57:47 EDT 2025
Fri Jun 27 04:55:02 EDT 2025
Thu May 22 21:24:20 EDT 2025
Thu Apr 24 22:53:13 EDT 2025
Tue Jul 01 01:11:06 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 7
Language English
License This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Creative Commons Attribution License
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c669t-a74a6d5915500cec19d0af30387b0efdcc8ae4c58cfbdb81153e4bc7536fd2663
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
ORCID 0000-0001-8901-4625
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pone.0236453
PMID 32726329
PQID 2428410442
PQPubID 1436336
PageCount e0236453
ParticipantIDs plos_journals_2428410442
doaj_primary_oai_doaj_org_article_3044f6080a304128b940975828b5bd27
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7390351
proquest_miscellaneous_2429054828
proquest_journals_2428410442
gale_infotracmisc_A630938455
gale_infotracacademiconefile_A630938455
gale_incontextgauss_ISR_A630938455
gale_incontextgauss_IOV_A630938455
gale_healthsolutions_A630938455
crossref_citationtrail_10_1371_journal_pone_0236453
crossref_primary_10_1371_journal_pone_0236453
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-07-29
PublicationDateYYYYMMDD 2020-07-29
PublicationDate_xml – month: 07
  year: 2020
  text: 2020-07-29
  day: 29
PublicationDecade 2020
PublicationPlace San Francisco
PublicationPlace_xml – name: San Francisco
– name: San Francisco, CA USA
PublicationTitle PloS one
PublicationYear 2020
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References KS Sheinerman (pone.0236453.ref033) 2012; 4
BJ Saab (pone.0236453.ref020) 2014; 80
F Angelucci (pone.0236453.ref010) 2019; 18
A Rani (pone.0236453.ref048) 2017; 9
Y Gao (pone.0236453.ref002) 2015; 109
WX Wang (pone.0236453.ref049) 2011; 121
P. Noone (pone.0236453.ref011) 2015; 65
RO Roberts (pone.0236453.ref054) 2014; 55
S Pichler (pone.0236453.ref023) 2017; 50
I Feinkohl (pone.0236453.ref004) 2015; 7
LM Bekris (pone.0236453.ref028) 2013; 18
GM Schratt (pone.0236453.ref038) 2006; 439
KF Hansen (pone.0236453.ref026) 2016; 23
JD Curb (pone.0236453.ref001) 1999; 52
S. Craft (pone.0236453.ref019) 2005; 26
KF Hansen (pone.0236453.ref029) 2013; 218
O Albai (pone.0236453.ref013) 2019; 15
L. Caracciolo (pone.0236453.ref041) 2018; 9
O Butovsky (pone.0236453.ref008) 2014; 17
JD Williamson (pone.0236453.ref005) 2014; 174
GJ Biessels (pone.0236453.ref006) 2018; 14
HZ Wu (pone.0236453.ref025) 2016; 49
S. Moradifard (pone.0236453.ref037) 2018; 8
II Salama (pone.0236453.ref014) 2019; 7
SM Son (pone.0236453.ref016) 2016; 12
D Klein (pone.0236453.ref042) 2013; 8
Y Qian (pone.0236453.ref022) 2017; 25
M Zhou (pone.0236453.ref047) 2018; 55
SA Ebady (pone.0236453.ref053) 2008; 82
M Muller (pone.0236453.ref032) 2014; 35
B Xie (pone.0236453.ref024) 2015; 45
KS Sheinerman (pone.0236453.ref009) 2013; 5
P Piscopo (pone.0236453.ref050) 2019; 50
D O'Carroll (pone.0236453.ref021) 2013; 38
NF Butte (pone.0236453.ref036) 2015; 102
Q Zhang (pone.0236453.ref034) 2014; 2014
GA Abdel-Latif (pone.0236453.ref052) 2020; 8
WQ Qiu (pone.0236453.ref015) 2006; 27
J Gao (pone.0236453.ref039) 2010; 466
O Ojo (pone.0236453.ref012) 2015; 12
P Kumar (pone.0236453.ref045) 2013; 8
XY Yuan (pone.0236453.ref051) 2017; 28
J. Q. Li (pone.0236453.ref003) 2016; 87
T Xu (pone.0236453.ref044) 2014; 18
R El Fatimy (pone.0236453.ref027) 2018; 136
L Geng (pone.0236453.ref031) 2018; 59
P Piscopo (pone.0236453.ref007) 2016; 8
N Baby (pone.0236453.ref040) 2020; 19
G Iacomino (pone.0236453.ref035) 2019; 14
P Lau (pone.0236453.ref030) 2013; 5
VN Mukhin (pone.0236453.ref017) 2017; 47
ST Ferreira (pone.0236453.ref018) 2015; 9
KJ Belongie (pone.0236453.ref043) 2017; 12
I Pichardo-Casas (pone.0236453.ref046) 2012; 3
References_xml – volume: 52
  start-page: 971
  year: 1999
  ident: pone.0236453.ref001
  article-title: Longitudinal association of vascular and Alzheimer’s dementias, diabetes, and glucose tolerance
  publication-title: Neurology
  doi: 10.1212/WNL.52.5.971
– volume: 27
  start-page: 190
  issue: 2
  year: 2006
  ident: pone.0236453.ref015
  article-title: Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer’s disease: review and hypothesis
  publication-title: Neurobiol. Aging
  doi: 10.1016/j.neurobiolaging.2005.01.004
– volume: 25
  start-page: 770
  issue: 8
  year: 2017
  ident: pone.0236453.ref022
  article-title: Advances in Roles of miR-132 in the Nervous System
  publication-title: Front. Pharmacol
  doi: 10.3389/fphar.2017.00770
– volume: 59
  start-page: 1096
  issue: 9
  year: 2018
  ident: pone.0236453.ref031
  article-title: Inhibition of miR-128 Abates Aβ-Mediated Cytotoxicity by Targeting PPAR-γ via NF-κB Inactivation in Primary Mouse Cortical Neurons and Neuro2a Cells
  publication-title: Yonsei Med J
  doi: 10.3349/ymj.2018.59.9.1096
– volume: 8
  start-page: e69807
  issue: 7
  year: 2013
  ident: pone.0236453.ref045
  article-title: Circulating miRNA Biomarkers for Alzheimer’s Disease
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0069807
– volume: 55
  start-page: 759
  issue: 5
  year: 2014
  ident: pone.0236453.ref054
  article-title: Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation
  publication-title: Journal of Nuclear Medicine
  doi: 10.2967/jnumed.113.132647
– volume: 35
  start-page: 152
  year: 2014
  ident: pone.0236453.ref032
  article-title: MicroRNAs in Alzheimer’s disease: differential expression in hippocampus and cell-free cerebrospinal fluid
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2013.07.005
– volume: 12
  start-page: e0182932
  issue: 8
  year: 2017
  ident: pone.0236453.ref043
  article-title: Identification of novel biomarkers to monitor β-cell function and enable early detection of type 2 diabetes risk
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0182932
– volume: 7
  start-page: 3253
  issue: 19
  year: 2019
  ident: pone.0236453.ref014
  article-title: Risk Factors Associated with Mild Cognitive Impairment аmong Apparently Healthy People and the Role of MicroRNAs
  publication-title: Open Access Macedonian Journal of Medical Sciences
  doi: 10.3889/oamjms.2019.834
– volume: 14
  start-page: 591
  year: 2018
  ident: pone.0236453.ref006
  article-title: Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications
  publication-title: Nat Rev Endocrinol
  doi: 10.1038/s41574-018-0048-7
– volume: 82
  start-page: 305
  issue: 3
  year: 2008
  ident: pone.0236453.ref053
  article-title: Investigation on the relationship between diabetes mellitus type 2 and cognitive impairment
  publication-title: Diabetes Research and Clinical Practice
  doi: 10.1016/j.diabres.2008.08.020
– volume: 109
  start-page: 299
  issue: 2
  year: 2015
  ident: pone.0236453.ref002
  article-title: The characteristic of cognitive function in Type2 diabetes mellitus
  publication-title: Diabetes research and clinical practice
  doi: 10.1016/j.diabres.2015.05.019
– volume: 17
  start-page: 131
  year: 2014
  ident: pone.0236453.ref008
  article-title: Identification of a unique TGF-b-dependent molecular and functional signature in microglia
  publication-title: Nat. Neurosci
  doi: 10.1038/nn.3599
– volume: 439
  start-page: 283
  issue: 7074
  year: 2006
  ident: pone.0236453.ref038
  article-title: A brain‐specific microRNA regulates dendritic spine development
  publication-title: Nature
  doi: 10.1038/nature04367
– volume: 5
  start-page: 925
  issue: 12
  year: 2013
  ident: pone.0236453.ref009
  article-title: Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study
  publication-title: AGING
  doi: 10.18632/aging.100624
– volume: 8
  start-page: 4767
  issue: 1
  year: 2018
  ident: pone.0236453.ref037
  article-title: Analysis of microrna and gene expression profiles in alzheimer’s disease:A meta‐analysis approach
  publication-title: Scientific Reports
  doi: 10.1038/s41598-018-20959-0
– volume: 14
  issue: 2
  year: 2019
  ident: pone.0236453.ref035
  article-title: Circulating microRNAs are associated with early childhood obesity: Results of the I.Family Study
  publication-title: Genes Nutr
– volume: 5
  start-page: 1613
  issue: 10
  year: 2013
  ident: pone.0236453.ref030
  article-title: (2013) Alteration of the microRNA network during the progression of Alzheimer’s disease
  publication-title: EMBO Mol. Med
  doi: 10.1002/emmm.201201974
– volume: 55
  start-page: 917
  issue: 2
  year: 2018
  ident: pone.0236453.ref047
  article-title: Abnormal Expression of MicroRNAs Induced by Chronic Unpredictable Mild Stress in Rat Hippocampal Tissues
  publication-title: Molecular eurobiology
  doi: 10.1007/s12035-016-0365-6
– volume: 50
  start-page: 131
  year: 2019
  ident: pone.0236453.ref050
  article-title: MicroRNAs and Mild Cognitive Impairment: a systematic review
  publication-title: Ageing Res Rev
  doi: 10.1016/j.arr.2018.11.005
– volume: 4
  start-page: 590
  issue: 9
  year: 2012
  ident: pone.0236453.ref033
  article-title: Plasma microRNA biomarkers for detection of mild cognitive impairment
  publication-title: Aging
  doi: 10.18632/aging.100486
– volume: 121
  start-page: 193
  issue: 2
  year: 2011
  ident: pone.0236453.ref049
  article-title: Patterns of microRNA expression in normal and early Alzheimer’s disease human temporal cortex: white matter versus gray matter
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-010-0756-0
– volume: 8
  start-page: 105
  issue: E
  year: 2020
  ident: pone.0236453.ref052
  article-title: Mild Cognitive Impairment among Type II Diabetes Mellitus Patients Attending University Teaching Hospital
  publication-title: Open Access Macedonian Journal of Medical Sciences
  doi: 10.3889/oamjms.2020.4245
– volume: 23
  start-page: 61
  issue: 2
  year: 2016
  ident: pone.0236453.ref026
  article-title: Targeted deletion of miR-132/−212 impairs memory and alters the hippocampal transcriptome
  publication-title: Learn. Mem
  doi: 10.1101/lm.039578.115
– volume: 174
  start-page: 324
  year: 2014
  ident: pone.0236453.ref005
  article-title: Action to Control Cardiovascular Risk in DiabetesMemory in Diabetes Investigators. Cognitive function and brain structure in persons with type 2 diabetesmellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial
  publication-title: JAMA Intern Med
  doi: 10.1001/jamainternmed.2013.13656
– volume: 38
  start-page: 39
  year: 2013
  ident: pone.0236453.ref021
  article-title: General Principals of miR Biogenesis and Regulation in the Brain. Neuropsychopharmacology
  publication-title: REVIEWS
– volume: 8
  start-page: e55064
  issue: 1
  year: 2013
  ident: pone.0236453.ref042
  article-title: MicroRNA Expression in Alpha and Beta Cells of Human Pancreatic Islets
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0055064
– volume: 8
  start-page: 17
  year: 2016
  ident: pone.0236453.ref007
  article-title: Fronto temporal Lobar Degeneration and MicroRNAs
  publication-title: Front Aging Neurosci
  doi: 10.3389/fnagi.2016.00017
– volume: 80
  start-page: 61
  year: 2014
  ident: pone.0236453.ref020
  article-title: Neuroepigenetics of memory formation and impairment: The role of microRNAs
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2014.01.026
– volume: 466
  start-page: 1105
  year: 2010
  ident: pone.0236453.ref039
  article-title: A novel pathway regulates memory and plasticity via SIRT1 and miR-134
  publication-title: Nature
  doi: 10.1038/nature09271
– volume: 2014
  start-page: 862473
  year: 2014
  ident: pone.0236453.ref034
  article-title: miR-375 and miR-30d in the effect of chromium-containing Chinese medicine moderating glucose metabolism
  publication-title: J Diabetes Res
  doi: 10.1155/2014/862473
– volume: 9
  start-page: 323
  year: 2017
  ident: pone.0236453.ref048
  article-title: miRNA in Circulating Microvesicles as Biomarkers for Age-Related Cognitive Decline
  publication-title: Front. Aging Neurosci
  doi: 10.3389/fnagi.2017.00323
– volume: 218
  start-page: 817
  issue: 3
  year: 2013
  ident: pone.0236453.ref029
  article-title: miR‐132: A dynamic regulator of cognitive capacity
  publication-title: Brain Struct Funct
  doi: 10.1007/s00429-012-0431-4
– volume: 65
  start-page: 418
  issue: 5
  year: 2015
  ident: pone.0236453.ref011
  article-title: Addenbrooke’s Cognitive Examination-III
  publication-title: Occupational Medicine
  doi: 10.1093/occmed/kqv041
– volume: 102
  start-page: 256
  issue: 2
  year: 2015
  ident: pone.0236453.ref036
  article-title: Global metabolomic profiling targeting childhood obesity in the Hispanic population
  publication-title: Am J Clin Nutr
  doi: 10.3945/ajcn.115.111872
– volume: 47
  start-page: 508
  issue: 5
  year: 2017
  ident: pone.0236453.ref017
  article-title: Mechanisms of Neuron Loss in Alzheimer’s Disease
  publication-title: Neuroscience and Behavioral Physiology
  doi: 10.1007/s11055-017-0427-x
– volume: 45
  start-page: 721
  issue: 3
  year: 2015
  ident: pone.0236453.ref024
  article-title: Serum miR-206 and miR-132 as Potential Circulating Biomarkers for Mild Cognitive Impairment
  publication-title: Journal of Alzheimer’s Disease
  doi: 10.3233/JAD-142847
– volume: 12
  start-page: 784
  issue: 5
  year: 2016
  ident: pone.0236453.ref016
  article-title: Insulin degrading enzyme secretion from astrocytes is mediated by an autophagy based unconventional secretory pathway in Alzheimer disease
  publication-title: Autophagy
  doi: 10.1080/15548627.2016.1159375
– volume: 87
  start-page: 476
  year: 2016
  ident: pone.0236453.ref003
  article-title: Risk factors for predicting progression from MCI to Alzheimer’s disease: a systematic review and meta-analysis of cohort studies
  publication-title: J. Neurol. Neurosurg. Psychiatry
  doi: 10.1136/jnnp-2014-310095
– volume: 12
  start-page: 8281
  year: 2015
  ident: pone.0236453.ref012
  article-title: Evaluating the Association between Diabetes, Cognitive Decline and Dementia
  publication-title: International Journal of Environmental Research and Public Health
  doi: 10.3390/ijerph120708281
– volume: 9
  year: 2015
  ident: pone.0236453.ref018
  article-title: Soluble amyloid-beta oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease
  publication-title: Front. Cell. Neurosci
  doi: 10.3389/fncel.2015.00191
– volume: 136
  start-page: 537
  year: 2018
  ident: pone.0236453.ref027
  article-title: MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-018-1880-5
– volume: 7
  start-page: 46
  year: 2015
  ident: pone.0236453.ref004
  article-title: The impact of diabetes on cognitive decline: potential vascular, metabolic, and psychosocial risk factors
  publication-title: Alzheimers Res Ther
  doi: 10.1186/s13195-015-0130-5
– volume: 28
  start-page: 715
  issue: 7
  year: 2017
  ident: pone.0236453.ref051
  article-title: Mild cognitive impairment in type 2 diabetes mellitus and related risk factors: a review
  publication-title: Rev Neurosci
  doi: 10.1515/revneuro-2017-0016
– volume: 18
  start-page: 665
  issue: 10
  year: 2019
  ident: pone.0236453.ref010
  article-title: MicroRNAs in Alzheimer’s Disease: Diagnostic Markers or Therapeutic Agents?
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2019.00665
– volume: 49
  start-page: 755
  issue: 3
  year: 2016
  ident: pone.0236453.ref025
  article-title: Circulating microRNAs as Biomarkers of Alzheimer's Disease: A Systematic Review
  publication-title: J Alzheimers Dis
– volume: 19
  start-page: e13046
  year: 2020
  ident: pone.0236453.ref040
  article-title: MicroRNA-134-5p inhibition rescues long-term plasticity and synaptic tagging/capture in an Aβ(1–42) induced model of Alzheimer’s disease
  publication-title: Aging Cell
  doi: 10.1111/acel.13046
– volume: 3
  start-page: 20
  issue: 1436
  year: 2012
  ident: pone.0236453.ref046
  article-title: Expression profiling of synaptic microRNAs from the adult rat brain identifies regional differences and seizure-induced dynamic modulation
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2011.12.001
– volume: 15
  start-page: 167
  year: 2019
  ident: pone.0236453.ref013
  article-title: Risk factors for developing dementia in type 2 diabetes mellitus patients with mild cognitive impairment
  publication-title: Neuropsychiatric Disease and Treatment
  doi: 10.2147/NDT.S189905
– volume: 9
  start-page: 2250
  issue: 1
  year: 2018
  ident: pone.0236453.ref041
  article-title: CREB controls cortical circuit plasticity and functional recovery after stroke
  publication-title: Nature Communications
  doi: 10.1038/s41467-018-04445-9
– volume: 50
  start-page: 167.e1
  year: 2017
  ident: pone.0236453.ref023
  article-title: The miRNome of Alzheimer's disease: consistent downregulation of the miR-132/212 cluster
  publication-title: Neurobiology of Aging
  doi: 10.1016/j.neurobiolaging.2016.09.019
– volume: 26
  start-page: 65
  issue: 1
  year: 2005
  ident: pone.0236453.ref019
  article-title: Insulin resistance syndrome and Alzheimer’s disease: age-and obesity-related effects on memory, amyloid, and inflammation
  publication-title: Neurobiol Aging.
  doi: 10.1016/j.neurobiolaging.2005.08.021
– volume: 18
  start-page: 153
  issue: 2
  year: 2014
  ident: pone.0236453.ref044
  article-title: MicroRNA-323-3p with clinical potential in rheumatoid arthritis, Alzheimer's disease and ectopic pregnancy
  publication-title: Expert Opin Ther Targets
  doi: 10.1517/14728222.2014.855201
– volume: 18
  start-page: 455
  issue: 5
  year: 2013
  ident: pone.0236453.ref028
  article-title: MicroRNA in Alzheimer’s disease: an exploratory study in brain, cerebrospinal fluid and plasma
  publication-title: Biomarkers
  doi: 10.3109/1354750X.2013.814073
SSID ssj0053866
Score 2.4218686
Snippet Objectives To assess the potential value of some miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI) among patients with type2 diabetes...
To assess the potential value of some miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI) among patients with type2 diabetes mellitus (T2DM)...
ObjectivesTo assess the potential value of some miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI) among patients with type2 diabetes mellitus...
Objectives To assess the potential value of some miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI) among patients with type2 diabetes...
SourceID plos
doaj
pubmedcentral
proquest
gale
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Enrichment Source
Index Database
StartPage e0236453
SubjectTerms Alzheimer's disease
Biology and Life Sciences
Biomarkers
Blood plasma
Blood pressure
Cognition
Cognition & reasoning
Cognitive ability
Cognitive disorders
Complications and side effects
Dementia
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diagnosis
Diagnostic systems
Disease
Drugs
Education
Gender
Gene expression
Genetic aspects
Health aspects
Hemoglobin
Hypertension
Identification methods
Impairment
Internal medicine
Lipids
Medicine
Medicine and Health Sciences
MicroRNA
MicroRNAs
miRNA
Pathology
Plasma
Quality of life
Regression analysis
Risk analysis
Risk factors
Sensitivity
Type 2 diabetes
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Jb9QwFLbQnLggyqIGChiEBBzSpvGS-DggqoJEQYWi3qx4g5FmMqPJzP_nPceJGgmpHLjGL1Hylvitnwl5zYIRXgWfeyFNzrFSaKTwOatLZUIhfalw3vnLhTy_4p-vxfWNo76wJ6yHB-4ZdwLhNg8S_JqGITRUbRQiNGGxxwjjyjhHDnveEEz1_2CwYinToByrTk-SXI4369YfR8x0wSYbUcTrH__Ks81y3U1czmnD5I0d6Ow-uZdcRzrvX_mA3PHtA3KQjLOjbxOC9LuHxH8Dn3jV0BV2211ezDuKU_bYiLPt6KKF60tHx8YhipOSiy2mCWk8e4gmsNWOYpaWYpaWlnTI0tIVYnju9t0jcnX28ceH8zydp5BbKdUubyreSCcQEb4orLenyhVNYFjANoUPztq68dyK2gbjTA2-IvPcWAhoZHCwkbPHZNYCBw8JVZVBXBchqsC5q0JtpHNAZLhiwtRFRtjAXG0T2DieebHUsYJWQdDRM02jSHQSSUby8a5ND7ZxC_17lNtIi1DZ8QIokE4KpG9ToIy8QKnrfu50NHg9l1gkrrkQGXkVKRAuo8V-nF_Nvuv0p68__4Ho--WE6E0iCmtgh23SDAR8E8JwTSiPJpRg9HayfIg6OnCl0-Bp1RxCa17CnYPe_n355biMD8Ueu9av95FGgQMPjMlINdH3CYOnK-3id8Qkr5jCmvST_yGRp-RuiVmNospLdURmu-3ePwPXb2eeRyv_A10mVp4
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELegSIgXxApogQEGIQEP2bL4K35CBTENpA00GOqbFX9tldqk1O3_jy91A5EQ8BpfUvXOdz7fx-8Qekm8Zk56lzvGdU4hU6g5czmpSql9wV0pod_57JyfXtJPUzZNAbeQyip3NrEz1LY1ECM_ikdJRePdgZZvlz9ymBoF2dU0QuMmugXQZVDSJab9hSvqMuepXY6I46MkncNl27jDDjmdkcFx1KH297Z5tJy3YeB4DssmfzuHTu6hu8mBxJOtxPfQDdeMYfZyqtMYo9tnKV0-RntJcwN-neCl39xH7kt0mBc1XkAp3sX5JGBowYcqnVXAsyY-n1vcVxVhaKOcrSCGiLvBRDghsQYMIVwMIVxc4l0IFy8A4HO9CQ_Q5cmHb-9P8zRsITecy3VeC1pzywAuviiMM8fSFrUnkN3WhfPWmKp21LDKeG11FR1J4qg28bbDvY2nPHmIRk1k7D7CUmgAfWFMeEqt8JXm1kYiTSVhuioyRHY8VyYhkcNAjLnq0msi3ki2vFQgKZUklaG8f2u5ReL4B_07EGdPCzja3YN2daWSWioSN5Tn0WuuCQCPVVoC_hekEjXTthQZegabQW2bUntroCYcMsgVZSxDLzoKwNJooFjnqt6EoD5-_v4fRF8vBkSvEpFvIztMnRok4n8CjK4B5cGAMloEM1jeh62740pQv3Qnvrnbzn9eft4vw0ehAK9x7aajkdG7j4zJkBiowYDBw5Vmdt0BlgsiIWH96O8__hjdKSGYUYi8lAdotF5t3JPo8a31006tfwIy1Vcs
  priority: 102
  providerName: ProQuest
Title Plasma microRNAs biomarkers in mild cognitive impairment among patients with type 2 diabetes mellitus
URI https://www.proquest.com/docview/2428410442
https://www.proquest.com/docview/2429054828
https://pubmed.ncbi.nlm.nih.gov/PMC7390351
https://doaj.org/article/3044f6080a304128b940975828b5bd27
http://dx.doi.org/10.1371/journal.pone.0236453
Volume 15
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELe2TkJ7QRsfWmEUg5CAh1Rp_BU_INRNLQNpZSoU9S2KHWer1KalaaXxwt-Oz3UiIg2BePFDfFepZ599vo_fIfSK5IoZmZvAMK4CCpFCxZkJSBxJlYfcRBLqnS9H_GJCP03ZdA9VPVu9AMs7n3bQT2qynndvv_94bxX-nevaIHoVU3e1LEzXIaIzso8O7N0kQFUvaR1XsNrNuS-g-xPnIbpHIgEw5rJxVzlI__rgbq3my7JhlTZzKn-7pIZH6L63LnF_tx2O0Z4pHqBjr78lfuNBpt8-RObKms2LFC8gIW886pcYCvEhV2dd4llhv88zXOcWYSimnK3Bk4hdeyLs8VhLDI5cDI5cHOHKkYsXAPO52ZaP0GQ4-Hp-EfiWC4HmXG6CVNCUZwxA48NQG92TWZjmBGLcKjR5pnWcGqpZrHOVqdiak8RQpe2bh-eZvevJY9QqrDBPEJZCAfQLYyKnNBN5rHiWWSJFJWEqDtuIVMJNtMcjh7YY88QF2YR9l-yElsDqJH512iiouVY7PI6_0J_ButW0gKbtPizX14lXzoSElObc2s4pAfixWElAAYOAomIqi0QbPYdVT3alqfWZkPQ5xJFjylgbvXQUgKhRQMrOdboty-Tj52__QPRl3CB67YnypRWHTn2ZhP1PgNTVoDxtUNpzQTemT2CPVlIpE2uMxdS-vmlkOat9e_f0i3oafhTS8Aqz3DoaaW18K5g2Eo393hBwc6aY3TjYckEkhK2f_DfnU3QYgbcjFEEkT1Frs96aZ9Yk3KgO2hdTYcf4vAfj8EMHHZwNRlfjjnOydNwpAOPPwS_1CGnJ
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6VIAEXRAOogUIXBAIObl2vd9c-IBQeVUObgEpb5Wa8D5dIiR3iRIg_xW9kxlkbLCHg0qt37CizszOz8_iGkCcsU9zGmfUsF8oLMVOoBLcei4JYZb6wQYz9zsORODwL34_5eIP8qHthsKyy1omVojaFxhj5HpiSKIS7Qxi8mn_1cGoUZlfrERprsTiy37_Bla18OXgL-_s0CA7enb459NxUAU8LES-9VIapMBxx0X1fW70fGz_NGKZxlW8zo3WU2lDzSGfKqAg8JmZDpcGtF5kBc8bgu1fIVTC8Pp4oOW4ueKA7hHDteUzu7zlp2J0Xud2tkNo5a5m_akpAYws682lRthzddpnmb3bv4Ba56RxW2l9L2CbZsHkXZz27upAuuTZ06fku2XSaoqTPHZz1i9vEfgQHfZbSGZb-nYz6JcWWf6wKWpR0ksPzqaFNFRPFts3JAmOWtBqERB3ya0kxZEwxZEwDWoeM6QwBRZer8g45u5RtuEs6OTB2i9BYKgSZ4VxmYWhkFilhDBCpMGZcRX6PsJrniXbI5ziAY5pU6TwJN6A1LxPcqcTtVI94zVvzNfLHP-hf43Y2tIjbXT0oFheJUwMJAwHOBHjpKUOgs0jFiDeGqUvFlQlkj-ygMCTrJthG-yR9gRnrKOS8Rx5XFIjdkWNx0EW6Kstk8OH8P4g-nbSInjmirAB26NQ1ZMB_QkywFuV2ixI0kG4tb6Ho1lwpk19nFd6sxfnPy4-aZfwoFvzltlhVNDHcJoAxPSJbx6DF4PZKPvlSAaRLFmOC_N7ff3yHXD88HR4nx4PR0X1yI8BAii-9IN4mneViZR-At7lUD6sjTsnny9YpPwG5vZVL
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1fb9MwELdGkSZeECugFQYzCAQ8ZE3j2E4eECqMamWsTINNfQuxY49KbVqaVoivxqfjLnUCkRDwstf4kqp35_P5_vyOkCfMKm5iazzDhfJCzBQqwY3HoiBW1hcmiLHf-WQkjs7Dd2M-3iI_ql4YLKusbGJpqLO5xhh5F46SKIS7Qxh0rSuLOD0cvFp89XCCFGZaq3EaGxU5Nt-_wfWteDk8BFk_DYLB209vjjw3YcDTQsQrL5VhKjKOGOm-r43uxZmfWoYpXeUbm2kdpSbUPNJWZSoC74mZUGlw8YXN4Ghj8N1r5LpkvId7TI7ryx7YESFcqx6Tva7TjIPFPDcHJWo7Z42jsJwYUJ8LrcV0XjSc3mbJ5m9n4OAWuemcV9rfaNsO2TJ5G-c-uxqRNtk-can6NtlxVqOgzx209YvbxJyCsz5L6QzLAM9G_YJi-z9WCC0LOsnh-TSjdUUTxRbOyRLjl7QcikQdCmxBMXxMMXxMA1qFj-kMwUVX6-IOOb8SMdwlrRwYu0toLBUCznAubRhm0kZKZBkQqTBmXEV-h7CK54l2KOg4jGOalKk9CbehDS8TlFTiJNUhXv3WYoMC8g_61yjOmhYxvMsH8-Vl4kxCwkCZrQCPPWUIehapGLHHMI2puMoC2SH7qAzJpiG2tkRJX2D2Ogo575DHJQXieOS4Iy7TdVEkww8X_0H08axB9MwR2TmwQ6euOQP-E-KDNSj3GpRgjXRjeRdVt-JKkfzat_Bmpc5_Xn5UL-NHsfgvN_N1SRPDzQIY0yGysQ0aDG6u5JMvJVi6ZDEmy-_9_cf3yTZYk-T9cHR8n9wIMKbiSy-I90hrtVybB-B4rtTDcodT8vmqTcpPn1aZgQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Plasma+microRNAs+biomarkers+in+mild+cognitive+impairment+among+patients+with+type+2+diabetes+mellitus&rft.jtitle=PloS+one&rft.au=Salama%2C+Iman+I.&rft.au=Sami%2C+Samia+M.&rft.au=Abdellatif%2C+Ghada+A.&rft.au=Mohsen%2C+Amira&rft.date=2020-07-29&rft.pub=Public+Library+of+Science&rft.eissn=1932-6203&rft.volume=15&rft.issue=7&rft_id=info:doi/10.1371%2Fjournal.pone.0236453&rft_id=info%3Apmid%2F32726329&rft.externalDocID=PMC7390351
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon