Accumulation of perfluoroalkyl substances in human tissues
Perfluoroalkyl substances (PFASs) are environmental pollutants with an important bioaccumulation potential. However, their metabolism and distribution in humans are not well studied. In this study, the concentrations of 21 PFASs were analyzed in 99 samples of autopsy tissues (brain, liver, lung, bon...
Saved in:
| Published in | Environment international Vol. 59; pp. 354 - 362 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Elsevier Ltd
01.09.2013
Elsevier |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Perfluoroalkyl substances (PFASs) are environmental pollutants with an important bioaccumulation potential. However, their metabolism and distribution in humans are not well studied. In this study, the concentrations of 21 PFASs were analyzed in 99 samples of autopsy tissues (brain, liver, lung, bone, and kidney) from subjects who had been living in Tarragona (Catalonia, Spain). The samples were analyzed by solvent extraction and online purification by turbulent flow and liquid chromatography coupled to tandem mass spectrometry. The occurrence of PFASs was confirmed in all human tissues. Although PFASs accumulation followed particular trends depending on the specific tissue, some similarities were found. In kidney and lung, perfluorobutanoic acid was the most frequent compound, and at highest concentrations (median values: 263 and 807ng/g in kidney and lung, respectively). In liver and brain, perfluorohexanoic acid showed the maximum levels (median: 68.3 and 141ng/g, respectively), while perfluorooctanoic acid was the most contributively in bone (median: 20.9ng/g). Lung tissues accumulated the highest concentration of PFASs. However, perfluorooctane sulfonic acid and perfluorooctanoic acid were more prevalent in liver and bone, respectively. To the best of our knowledge, the accumulation of different PFASs in samples of various human tissues from the same subjects is here reported for the very first time. The current results may be of high importance for the validation of physiologically based pharmacokinetic models, which are being developed for humans. However, further studies on the distribution of the same compounds in the human body are still required.
•21 perfluoroalkyl substances were analyzed in 99 samples of human autopsy tissues.•The occurrence of perfluoroalkyl substances was confirmed in all human tissues.•Accumulation of PFASs followed particular trends depending on the specific tissue.•Lung was found to be the tissue accumulating a higher concentration of PFASs. |
|---|---|
| AbstractList | Perfluoroalkyl substances (PFASs) are environmental pollutants with an important bioaccumulation potential. However, their metabolism and distribution in humans are not well studied. In this study, the concentrations of 21 PFASs were analyzed in 99 samples of autopsy tissues (brain, liver, lung, bone, and kidney) from subjects who had been living in Tarragona (Catalonia, Spain). The samples were analyzed by solvent extraction and online purification by turbulent flow and liquid chromatography coupled to tandem mass spectrometry. The occurrence of PFASs was confirmed in all human tissues. Although PFASs accumulation followed particular trends depending on the specific tissue, some similarities were found. In kidney and lung, perfluorobutanoic acid was the most frequent compound, and at highest concentrations (median values: 263 and 807ng/g in kidney and lung, respectively). In liver and brain, perfluorohexanoic acid showed the maximum levels (median: 68.3 and 141ng/g, respectively), while perfluorooctanoic acid was the most contributively in bone (median: 20.9ng/g). Lung tissues accumulated the highest concentration of PFASs. However, perfluorooctane sulfonic acid and perfluorooctanoic acid were more prevalent in liver and bone, respectively. To the best of our knowledge, the accumulation of different PFASs in samples of various human tissues from the same subjects is here reported for the very first time. The current results may be of high importance for the validation of physiologically based pharmacokinetic models, which are being developed for humans. However, further studies on the distribution of the same compounds in the human body are still required. Perfluoroalkyl substances (PFASs) are environmental pollutants with an important bioaccumulation potential. However, their metabolism and distribution in humans are not well studied. In this study, the concentrations of 21 PFASs were analyzed in 99 samples of autopsy tissues (brain, liver, lung, bone, and kidney) from subjects who had been living in Tarragona (Catalonia, Spain). The samples were analyzed by solvent extraction and online purification by turbulent flow and liquid chromatography coupled to tandem mass spectrometry. The occurrence of PFASs was confirmed in all human tissues. Although PFASs accumulation followed particular trends depending on the specific tissue, some similarities were found. In kidney and lung, perfluorobutanoic acid was the most frequent compound, and at highest concentrations (median values: 263 and 807ng/g in kidney and lung, respectively). In liver and brain, perfluorohexanoic acid showed the maximum levels (median: 68.3 and 141ng/g, respectively), while perfluorooctanoic acid was the most contributively in bone (median: 20.9ng/g). Lung tissues accumulated the highest concentration of PFASs. However, perfluorooctane sulfonic acid and perfluorooctanoic acid were more prevalent in liver and bone, respectively. To the best of our knowledge, the accumulation of different PFASs in samples of various human tissues from the same subjects is here reported for the very first time. The current results may be of high importance for the validation of physiologically based pharmacokinetic models, which are being developed for humans. However, further studies on the distribution of the same compounds in the human body are still required.Perfluoroalkyl substances (PFASs) are environmental pollutants with an important bioaccumulation potential. However, their metabolism and distribution in humans are not well studied. In this study, the concentrations of 21 PFASs were analyzed in 99 samples of autopsy tissues (brain, liver, lung, bone, and kidney) from subjects who had been living in Tarragona (Catalonia, Spain). The samples were analyzed by solvent extraction and online purification by turbulent flow and liquid chromatography coupled to tandem mass spectrometry. The occurrence of PFASs was confirmed in all human tissues. Although PFASs accumulation followed particular trends depending on the specific tissue, some similarities were found. In kidney and lung, perfluorobutanoic acid was the most frequent compound, and at highest concentrations (median values: 263 and 807ng/g in kidney and lung, respectively). In liver and brain, perfluorohexanoic acid showed the maximum levels (median: 68.3 and 141ng/g, respectively), while perfluorooctanoic acid was the most contributively in bone (median: 20.9ng/g). Lung tissues accumulated the highest concentration of PFASs. However, perfluorooctane sulfonic acid and perfluorooctanoic acid were more prevalent in liver and bone, respectively. To the best of our knowledge, the accumulation of different PFASs in samples of various human tissues from the same subjects is here reported for the very first time. The current results may be of high importance for the validation of physiologically based pharmacokinetic models, which are being developed for humans. However, further studies on the distribution of the same compounds in the human body are still required. Perfluoroalkyl substances (PFASs) are environmental pollutants with an important bioaccumulation potential. However, their metabolism and distribution in humans are not well studied. In this study, the concentrations of 21 PFASs were analyzed in 99 samples of autopsy tissues (brain, liver, lung, bone, and kidney) from subjects who had been living in Tarragona (Catalonia, Spain). The samples were analyzed by solvent extraction and online purification by turbulent flow and liquid chromatography coupled to tandem mass spectrometry. The occurrence of PFASs was confirmed in all human tissues. Although PFASs accumulation followed particular trends depending on the specific tissue, some similarities were found. In kidney and lung, perfluorobutanoic acid was the most frequent compound, and at highest concentrations (median values: 263 and 807 ng/g in kidney and lung, respectively). In liver and brain, perfluorohexanoic acid showed the maximum levels (median: 68.3 and 141 ng/g, respectively), while perfluorooctanoic acid was the most contributively in bone (median: 20.9 ng/g). Lung tissues accumulated the highest concentration of PFASs. However, perfluorooctane sulfonic acid and perfluorooctanoic acid were more prevalent in liver and bone, respectively. To the best of our knowledge, the accumulation of different PFASs in samples of various human tissues from the same subjects is here reported for the very first time. The current results may be of high importance for the validation of physiologically based pharmacokinetic models, which are being developed for humans. However, further studies on the distribution of the same compounds in the human body are still required. Keywords: Perfluoroalkyl substances (PFASs), Human distribution, Tissues, Turbulent flow chromatography coupled to tandem mass spectrometry (TFC-LC-MS/MS), Principal Component Analysis Perfluoroalkyl substances (PFASs) are environmental pollutants with an important bioaccumulation potential. However, their metabolism and distribution in humans are not well studied. In this study, the concentrations of 21 PFASs were analyzed in 99 samples of autopsy tissues (brain, liver, lung, bone, and kidney) from subjects who had been living in Tarragona (Catalonia, Spain). The samples were analyzed by solvent extraction and online purification by turbulent flow and liquid chromatography coupled to tandem mass spectrometry. The occurrence of PFASs was confirmed in all human tissues. Although PFASs accumulation followed particular trends depending on the specific tissue, some similarities were found. In kidney and lung, perfluorobutanoic acid was the most frequent compound, and at highest concentrations (median values: 263 and 807ng/g in kidney and lung, respectively). In liver and brain, perfluorohexanoic acid showed the maximum levels (median: 68.3 and 141ng/g, respectively), while perfluorooctanoic acid was the most contributively in bone (median: 20.9ng/g). Lung tissues accumulated the highest concentration of PFASs. However, perfluorooctane sulfonic acid and perfluorooctanoic acid were more prevalent in liver and bone, respectively. To the best of our knowledge, the accumulation of different PFASs in samples of various human tissues from the same subjects is here reported for the very first time. The current results may be of high importance for the validation of physiologically based pharmacokinetic models, which are being developed for humans. However, further studies on the distribution of the same compounds in the human body are still required. •21 perfluoroalkyl substances were analyzed in 99 samples of human autopsy tissues.•The occurrence of perfluoroalkyl substances was confirmed in all human tissues.•Accumulation of PFASs followed particular trends depending on the specific tissue.•Lung was found to be the tissue accumulating a higher concentration of PFASs. |
| Author | Pérez, Francisca Fàbrega, Francesc Barceló, Damià Nadal, Martí Domingo, José L. Farré, Marinella Navarro-Ortega, Alícia |
| Author_xml | – sequence: 1 givenname: Francisca surname: Pérez fullname: Pérez, Francisca organization: Water and Soil Quality Research Group, Dept. of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain – sequence: 2 givenname: Martí surname: Nadal fullname: Nadal, Martí organization: Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Sant Llorenç 21, Reus, Spain – sequence: 3 givenname: Alícia surname: Navarro-Ortega fullname: Navarro-Ortega, Alícia organization: Water and Soil Quality Research Group, Dept. of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain – sequence: 4 givenname: Francesc surname: Fàbrega fullname: Fàbrega, Francesc organization: Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Sant Llorenç 21, Reus, Spain – sequence: 5 givenname: José L. surname: Domingo fullname: Domingo, José L. organization: Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Sant Llorenç 21, Reus, Spain – sequence: 6 givenname: Damià surname: Barceló fullname: Barceló, Damià organization: Water and Soil Quality Research Group, Dept. of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain – sequence: 7 givenname: Marinella surname: Farré fullname: Farré, Marinella email: mfuqam@cid.csic.es organization: Water and Soil Quality Research Group, Dept. of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27716645$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/23892228$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkl1rFDEUhoNU7Lb6D0TmRvBm1px8Ty-EUtQWCt7odcjkQ7POTtZkptB_b7azVvCi61Xg8LwvOZznDJ2MafQIvQa8Bgzi_Wbtx7s4TmuCga6xWGPMnqEVKElbITk-QauK4ZYBwaforJQNxpgwxV-gU0JVRwhRK3Rxae28nQczxTQ2KTQ7n8Mwp5zM8PN-aMrcl8mM1pcmjs2PeWvGZoqlzL68RM-DGYp_dXjP0bdPH79eXbe3Xz7fXF3etlaIbmo7T3jAxgbhefAgGCEMeKDMCaBYOOgldMpzHoAqTAK10llBpFSudz3x9BzdLL0umY3e5bg1-V4nE_XDIOXv2uQp2sFrwYEJpQjjnDHKSeec5SJY5xhRTkHterd07XL6VXeY9DYW64fBjD7NRYPEnFEAoo6jQnFZcSD_gUpBuWIdPY4y0immMOw_8OaAzv3Wu8fN_xyvAm8PgCnWDCHXO8Xyl5MShGC8cmzhbE6lZB8eEcB675Le6MUlvXdJY6GrSzV28U_MxunBkymbOBwLf1jCvppxF33WxUZfPXIxezvV08WnC34Dq5jjaA |
| CODEN | ENVIDV |
| CitedBy_id | crossref_primary_10_3390_toxics12020104 crossref_primary_10_1016_j_cocis_2015_07_004 crossref_primary_10_3389_ftox_2023_1244457 crossref_primary_10_1021_acs_est_3c02765 crossref_primary_10_1016_j_ecoenv_2020_111105 crossref_primary_10_1016_j_envint_2021_106906 crossref_primary_10_1016_j_emcon_2020_12_003 crossref_primary_10_1007_s10118_017_1966_x crossref_primary_10_1186_s12940_015_0066_z crossref_primary_10_1016_j_scitotenv_2025_178803 crossref_primary_10_1016_j_envint_2022_107274 crossref_primary_10_3389_ftox_2022_1000212 crossref_primary_10_1016_j_chemosphere_2024_143213 crossref_primary_10_1016_j_tox_2022_153281 crossref_primary_10_1210_endocr_bqab194 crossref_primary_10_1002_cmtd_202300017 crossref_primary_10_1016_j_heliyon_2019_e02168 crossref_primary_10_1073_pnas_2408575121 crossref_primary_10_1016_j_scitotenv_2022_158362 crossref_primary_10_1289_EHP4918 crossref_primary_10_1080_02772248_2015_1060976 crossref_primary_10_1038_s41598_025_85967_3 crossref_primary_10_1016_j_scenv_2023_100047 crossref_primary_10_1016_j_toxrep_2021_11_014 crossref_primary_10_1016_j_scitotenv_2023_169861 crossref_primary_10_1007_s00129_023_05125_6 crossref_primary_10_1016_j_envres_2023_115621 crossref_primary_10_1016_j_envint_2024_108838 crossref_primary_10_1039_D3EW00543G crossref_primary_10_1016_j_ecoenv_2023_115209 crossref_primary_10_1016_j_chemosphere_2024_142253 crossref_primary_10_1071_CH23061 crossref_primary_10_1016_j_chemosphere_2024_141164 crossref_primary_10_1039_D1RA09072K crossref_primary_10_1016_j_hazl_2023_100079 crossref_primary_10_1097_JOM_0000000000002479 crossref_primary_10_1021_acs_jafc_2c06365 crossref_primary_10_1016_j_envres_2015_03_012 crossref_primary_10_1016_j_scitotenv_2018_11_453 crossref_primary_10_1016_j_envres_2014_08_011 crossref_primary_10_1021_acs_estlett_9b00786 crossref_primary_10_1016_j_envint_2022_107379 crossref_primary_10_1186_s12940_022_00958_5 crossref_primary_10_1016_j_envint_2020_105789 crossref_primary_10_1016_j_toxlet_2021_06_004 crossref_primary_10_1016_j_scitotenv_2019_136417 crossref_primary_10_2139_ssrn_4168679 crossref_primary_10_3389_fendo_2021_799043 crossref_primary_10_1016_j_envint_2021_106819 crossref_primary_10_3390_ijms241411707 crossref_primary_10_1080_26896583_2025_2460884 crossref_primary_10_1002_cbic_202300159 crossref_primary_10_1002_wer_70039 crossref_primary_10_1016_j_envres_2024_120160 crossref_primary_10_1016_j_fct_2023_113781 crossref_primary_10_1021_acs_chemrestox_7b00265 crossref_primary_10_1016_j_envres_2019_02_024 crossref_primary_10_1007_s00216_020_02692_8 crossref_primary_10_1007_s11356_023_26119_w crossref_primary_10_1016_j_tox_2022_153116 crossref_primary_10_1016_j_envint_2024_108615 crossref_primary_10_1016_j_envpol_2022_119820 crossref_primary_10_1038_s41545_023_00274_6 crossref_primary_10_3389_fvets_2024_1500651 crossref_primary_10_3390_ijerph18073794 crossref_primary_10_1021_acs_est_7b02080 crossref_primary_10_3390_ijerph18052734 crossref_primary_10_2903_j_efsa_2018_5194 crossref_primary_10_1002_hep_31483 crossref_primary_10_1016_j_envint_2023_108340 crossref_primary_10_1016_j_watres_2023_120135 crossref_primary_10_1186_s12940_024_01126_7 crossref_primary_10_1007_s10570_023_05304_7 crossref_primary_10_1021_acs_est_8b07188 crossref_primary_10_1016_j_envpol_2024_124865 crossref_primary_10_1071_RD24034 crossref_primary_10_1016_j_jhazmat_2021_126827 crossref_primary_10_1016_j_envres_2021_111775 crossref_primary_10_1016_j_envint_2024_108719 crossref_primary_10_3390_ijerph20010821 crossref_primary_10_1016_j_chemosphere_2021_131775 crossref_primary_10_1016_j_envres_2024_120461 crossref_primary_10_1021_acs_chemrestox_1c00424 crossref_primary_10_1289_EHP11360 crossref_primary_10_1021_acs_chemrestox_2c00072 crossref_primary_10_1007_s11356_023_30022_9 crossref_primary_10_1016_j_envint_2016_09_015 crossref_primary_10_1021_acs_estlett_5b00049 crossref_primary_10_1038_s41370_021_00386_6 crossref_primary_10_1016_j_jhazmat_2022_130003 crossref_primary_10_1021_acs_est_4c04050 crossref_primary_10_3389_fbioe_2020_602040 crossref_primary_10_1007_s00204_025_04019_x crossref_primary_10_1016_j_scitotenv_2023_164096 crossref_primary_10_1016_j_scitotenv_2022_153900 crossref_primary_10_1016_j_chemosphere_2020_129029 crossref_primary_10_1021_acs_jpcb_1c08214 crossref_primary_10_1021_acsomega_8b00123 crossref_primary_10_1002_jat_3883 crossref_primary_10_1007_s11356_022_20085_5 crossref_primary_10_1097_JOM_0000000000003020 crossref_primary_10_1016_j_horiz_2024_100116 crossref_primary_10_1016_j_chemosphere_2024_143396 crossref_primary_10_1016_j_envint_2024_108864 crossref_primary_10_1007_s12403_023_00622_4 crossref_primary_10_1016_j_jare_2024_04_022 crossref_primary_10_1016_j_rvsc_2025_105585 crossref_primary_10_1016_j_chemosphere_2022_134083 crossref_primary_10_1016_j_scitotenv_2017_04_058 crossref_primary_10_1016_j_scitotenv_2022_159557 crossref_primary_10_1016_j_chemosphere_2023_138863 crossref_primary_10_1021_acs_chemrestox_2c00078 crossref_primary_10_1016_j_chemosphere_2020_127115 crossref_primary_10_1016_j_reprotox_2023_108528 crossref_primary_10_1021_acs_est_7b06128 crossref_primary_10_1016_j_envadv_2023_100344 crossref_primary_10_1016_j_ecoenv_2018_12_086 crossref_primary_10_1021_acs_estlett_0c00255 crossref_primary_10_3389_fendo_2024_1343887 crossref_primary_10_1016_j_jhazmat_2024_136205 crossref_primary_10_1016_j_chemosphere_2019_04_195 crossref_primary_10_1002_jms_4667 crossref_primary_10_1029_2020GL087535 crossref_primary_10_1007_s40572_018_0173_4 crossref_primary_10_1016_j_chemosphere_2020_126016 crossref_primary_10_1021_acs_jpcb_7b05901 crossref_primary_10_1016_j_envint_2018_07_013 crossref_primary_10_2131_jts_42_301 crossref_primary_10_1186_s12940_022_00929_w crossref_primary_10_1002_jat_4270 crossref_primary_10_1007_s00204_025_03984_7 crossref_primary_10_1289_EHP11847 crossref_primary_10_1016_j_scitotenv_2020_142943 crossref_primary_10_1021_acs_est_4c03652 crossref_primary_10_1080_1547691X_2024_2340495 crossref_primary_10_1016_j_taap_2017_07_001 crossref_primary_10_1016_j_scitotenv_2024_173325 crossref_primary_10_3390_ijerph19010574 crossref_primary_10_1007_s00216_016_9319_0 crossref_primary_10_1007_s10646_022_02576_w crossref_primary_10_1016_j_chemosphere_2024_143745 crossref_primary_10_1016_j_envint_2021_107068 crossref_primary_10_1002_jat_4383 crossref_primary_10_1016_j_tox_2020_152565 crossref_primary_10_1016_j_envres_2019_01_045 crossref_primary_10_1038_s41370_024_00742_2 crossref_primary_10_1016_j_scitotenv_2023_164576 crossref_primary_10_1021_acs_est_4c06805 crossref_primary_10_1080_26395940_2025_2475955 crossref_primary_10_1021_acs_est_2c05642 crossref_primary_10_1016_j_chemosphere_2024_141694 crossref_primary_10_1021_acs_estlett_7b00042 crossref_primary_10_1073_pnas_2011957118 crossref_primary_10_1016_j_csbj_2024_06_036 crossref_primary_10_1016_j_chemosphere_2024_141699 crossref_primary_10_1093_toxres_tfae151 crossref_primary_10_1016_j_jece_2022_107351 crossref_primary_10_1016_j_envint_2023_107951 crossref_primary_10_1016_j_scitotenv_2022_160617 crossref_primary_10_1016_j_tem_2024_07_021 crossref_primary_10_1007_s00216_023_04867_5 crossref_primary_10_3390_foods12071423 crossref_primary_10_1016_j_envpol_2020_115611 crossref_primary_10_1007_s10661_017_6084_2 crossref_primary_10_1016_j_scitotenv_2024_176717 crossref_primary_10_1016_j_envres_2023_116651 crossref_primary_10_1016_j_chemosphere_2024_143887 crossref_primary_10_1016_j_scitotenv_2024_174478 crossref_primary_10_1016_j_envres_2023_117743 crossref_primary_10_1016_j_fct_2021_112175 crossref_primary_10_1016_j_envres_2020_109439 crossref_primary_10_1016_j_taap_2020_115250 crossref_primary_10_2215_CJN_04670418 crossref_primary_10_1016_j_envpol_2020_114928 crossref_primary_10_1016_j_ecoenv_2025_117925 crossref_primary_10_1021_acs_jafc_3c01344 crossref_primary_10_1016_j_envres_2020_109676 crossref_primary_10_1016_j_taap_2024_117047 crossref_primary_10_1016_j_jenvman_2015_09_023 crossref_primary_10_1128_aem_00533_23 crossref_primary_10_1016_j_scitotenv_2020_137333 crossref_primary_10_1016_j_scitotenv_2022_156891 crossref_primary_10_1016_j_chemosphere_2019_125074 crossref_primary_10_1016_j_chemosphere_2022_136438 crossref_primary_10_1016_j_envint_2018_06_028 crossref_primary_10_2478_aiht_2022_73_3629 crossref_primary_10_1007_s11356_022_23086_6 crossref_primary_10_1021_acsestwater_1c00239 crossref_primary_10_3390_physiologia4040035 crossref_primary_10_3390_toxics10120776 crossref_primary_10_1016_j_ecoenv_2018_12_034 crossref_primary_10_1016_j_envint_2018_06_015 crossref_primary_10_1016_j_chemosphere_2024_143665 crossref_primary_10_2139_ssrn_3986110 crossref_primary_10_35371_aoem_2023_35_e5 crossref_primary_10_3390_atmos15091126 crossref_primary_10_1016_j_scitotenv_2021_145257 crossref_primary_10_1038_s41370_018_0099_9 crossref_primary_10_1021_jacs_4c02934 crossref_primary_10_1093_jnci_djaa143 crossref_primary_10_1002_pro_4036 crossref_primary_10_1016_j_ijheh_2024_114459 crossref_primary_10_1002_cssc_202401391 crossref_primary_10_1016_j_chroma_2016_09_050 crossref_primary_10_1021_acs_est_9b07102 crossref_primary_10_1021_acs_chemrestox_2c00344 crossref_primary_10_1016_j_fct_2022_113515 crossref_primary_10_1016_j_chemosphere_2024_143673 crossref_primary_10_3390_su16198391 crossref_primary_10_1016_j_aca_2023_341206 crossref_primary_10_1016_j_tjnut_2024_01_018 crossref_primary_10_1016_j_chemosphere_2024_141379 crossref_primary_10_1016_j_envres_2023_117611 crossref_primary_10_1021_acs_est_9b00715 crossref_primary_10_1007_s11356_020_11855_0 crossref_primary_10_1016_j_scitotenv_2015_07_045 crossref_primary_10_1186_s12302_015_0063_4 crossref_primary_10_1016_j_ijheh_2021_113830 crossref_primary_10_1007_s40726_023_00269_4 crossref_primary_10_1016_j_envint_2024_108497 crossref_primary_10_1016_j_reprotox_2016_07_010 crossref_primary_10_1016_j_yrtph_2019_104452 crossref_primary_10_1016_j_envres_2021_111287 crossref_primary_10_1021_acs_est_3c07415 crossref_primary_10_1016_j_envres_2021_112011 crossref_primary_10_1097_EE9_0000000000000368 crossref_primary_10_3389_fendo_2022_980608 crossref_primary_10_1016_j_envint_2019_03_002 crossref_primary_10_1016_j_chemosphere_2024_142907 crossref_primary_10_1038_s41370_022_00452_7 crossref_primary_10_3390_toxics10050265 crossref_primary_10_3390_ijerph18168345 crossref_primary_10_1016_j_scitotenv_2024_174962 crossref_primary_10_1016_j_scitotenv_2022_153561 crossref_primary_10_1007_s10661_017_5921_7 crossref_primary_10_3390_ijerph17218020 crossref_primary_10_1016_j_apgeochem_2018_12_016 crossref_primary_10_1021_acsami_0c20352 crossref_primary_10_1016_j_emcon_2021_02_001 crossref_primary_10_1016_j_envres_2020_109920 crossref_primary_10_1093_toxsci_kfad108 crossref_primary_10_1016_j_idairyj_2019_04_008 crossref_primary_10_1021_acs_accounts_2c00591 crossref_primary_10_1155_2019_2717528 crossref_primary_10_1016_j_jhazmat_2023_130911 crossref_primary_10_1007_s00449_022_02694_z crossref_primary_10_1007_s00204_019_02634_z crossref_primary_10_1021_acs_est_3c10824 crossref_primary_10_2139_ssrn_4008090 crossref_primary_10_1016_j_etap_2023_104062 crossref_primary_10_1021_acs_macromol_4c02993 crossref_primary_10_1016_j_reprotox_2023_108383 crossref_primary_10_1016_j_chemosphere_2025_144230 crossref_primary_10_1016_j_foodres_2020_109583 crossref_primary_10_1007_s11356_022_20156_7 crossref_primary_10_1016_j_reprotox_2024_108745 crossref_primary_10_1093_toxsci_kfae103 crossref_primary_10_1016_j_taap_2022_116284 crossref_primary_10_1371_journal_pone_0244815 crossref_primary_10_1186_s13048_021_00903_z crossref_primary_10_1517_14728222_2015_1039513 crossref_primary_10_1021_jf501113j crossref_primary_10_1016_j_envpol_2020_115207 crossref_primary_10_1016_j_envint_2023_108087 crossref_primary_10_1093_humupd_dmaa018 crossref_primary_10_1016_j_envpol_2019_01_064 crossref_primary_10_1016_j_ijheh_2024_114380 crossref_primary_10_3389_ftox_2024_1347965 crossref_primary_10_1016_j_neuro_2021_10_013 crossref_primary_10_1016_j_ecoenv_2019_109499 crossref_primary_10_1016_j_envres_2024_120606 crossref_primary_10_3389_fgene_2021_721507 crossref_primary_10_1016_j_envres_2017_10_014 crossref_primary_10_1016_j_envpol_2023_122910 crossref_primary_10_1016_j_chemosphere_2024_141723 crossref_primary_10_3390_toxics11020126 crossref_primary_10_3390_molecules29246029 crossref_primary_10_1016_j_envres_2019_108578 crossref_primary_10_1016_j_jhazmat_2022_128615 crossref_primary_10_1016_j_ecoenv_2024_117524 crossref_primary_10_1186_s12940_021_00758_3 crossref_primary_10_3390_medsci4030013 crossref_primary_10_1016_j_taap_2016_04_002 crossref_primary_10_1016_j_neuro_2023_05_005 crossref_primary_10_1021_acs_est_3c10511 crossref_primary_10_1016_j_reprotox_2020_10_013 crossref_primary_10_1016_j_scitotenv_2023_167945 crossref_primary_10_2903_sp_efsa_2024_EN_8926 crossref_primary_10_1016_j_envpol_2022_119020 crossref_primary_10_1016_j_envint_2024_109140 crossref_primary_10_1021_acs_est_1c06479 crossref_primary_10_1016_j_scitotenv_2024_176941 crossref_primary_10_3390_ijerph17051668 crossref_primary_10_1021_acs_chemrestox_8b00002 crossref_primary_10_1111_1541_4337_12726 crossref_primary_10_1016_j_chemgeo_2020_119778 crossref_primary_10_1080_10643389_2023_2223118 crossref_primary_10_1080_10934529_2016_1253402 crossref_primary_10_1016_j_envres_2025_121175 crossref_primary_10_1021_acs_estlett_1c01009 crossref_primary_10_3390_antiox11061115 crossref_primary_10_1016_j_jpowsour_2024_236104 crossref_primary_10_1021_acs_est_3c06499 crossref_primary_10_1016_j_polymer_2017_02_073 crossref_primary_10_1021_acschemneuro_4c00652 crossref_primary_10_1021_acsomega_4c03767 crossref_primary_10_1007_s00216_022_04088_2 crossref_primary_10_1093_toxsci_kfab039 crossref_primary_10_1016_j_neuro_2020_01_001 crossref_primary_10_1016_j_cej_2025_159296 crossref_primary_10_1016_j_yrtph_2016_03_009 crossref_primary_10_1021_acs_est_0c00175 crossref_primary_10_1038_s41598_017_07359_6 crossref_primary_10_1016_j_cnd_2024_10_003 crossref_primary_10_1038_nrneph_2015_94 crossref_primary_10_3390_toxics12050348 crossref_primary_10_1016_j_jenvman_2023_118978 crossref_primary_10_1016_j_envres_2025_121181 crossref_primary_10_1016_j_neuro_2022_04_004 crossref_primary_10_1007_s11356_020_12293_8 crossref_primary_10_1016_j_chemosphere_2023_140380 crossref_primary_10_1021_envhealth_3c00129 crossref_primary_10_1016_j_envint_2024_109033 crossref_primary_10_1016_j_apsusc_2024_160961 crossref_primary_10_1016_j_jhazmat_2022_129819 crossref_primary_10_1093_toxres_tfad027 crossref_primary_10_1016_j_colsurfa_2016_05_016 crossref_primary_10_1016_j_ijheh_2021_113796 crossref_primary_10_1002_etc_4890 crossref_primary_10_1016_j_scitotenv_2023_163431 crossref_primary_10_1016_j_chemosphere_2024_141527 crossref_primary_10_1016_j_jhepr_2022_100550 crossref_primary_10_1016_j_chemosphere_2020_128608 crossref_primary_10_1007_s12403_023_00607_3 crossref_primary_10_1016_j_foodcont_2021_108330 crossref_primary_10_1016_j_chemosphere_2024_143168 crossref_primary_10_1016_j_ebiom_2023_104699 crossref_primary_10_1016_j_tox_2021_153031 crossref_primary_10_1021_acsestengg_4c00107 crossref_primary_10_1016_j_envres_2024_119442 crossref_primary_10_1080_10408444_2021_1888073 crossref_primary_10_1021_acs_estlett_1c00901 crossref_primary_10_1007_s11356_018_2951_9 crossref_primary_10_1016_j_fct_2020_111710 crossref_primary_10_1016_j_scitotenv_2020_144107 crossref_primary_10_1007_s12011_014_9957_z crossref_primary_10_1186_s12940_023_01008_4 crossref_primary_10_3390_app12105242 crossref_primary_10_1016_j_fct_2021_112528 crossref_primary_10_1016_j_envres_2017_01_025 crossref_primary_10_2903_j_efsa_2020_6223 crossref_primary_10_1016_j_scitotenv_2022_154939 crossref_primary_10_3390_metabo14070392 crossref_primary_10_1016_j_envpol_2020_115385 crossref_primary_10_1289_EHP5184 crossref_primary_10_1289_EHP4092 crossref_primary_10_1016_j_envint_2019_01_010 crossref_primary_10_1021_acs_est_7b03647 crossref_primary_10_1016_j_envint_2021_106400 crossref_primary_10_1016_j_chemosphere_2019_124755 crossref_primary_10_1038_s41598_020_74026_8 crossref_primary_10_1016_j_envint_2021_106524 crossref_primary_10_1002_etc_4954 crossref_primary_10_1016_j_envint_2017_01_016 crossref_primary_10_1016_j_envpol_2023_121650 crossref_primary_10_1093_toxsci_kfaf013 crossref_primary_10_3389_fendo_2021_632927 crossref_primary_10_1007_s10695_022_01093_1 crossref_primary_10_1016_j_envres_2017_01_014 crossref_primary_10_1097_EE9_0000000000000092 crossref_primary_10_1016_j_envint_2016_11_014 crossref_primary_10_1016_j_fct_2021_112751 crossref_primary_10_1186_s12940_023_01019_1 crossref_primary_10_3390_toxics5040031 crossref_primary_10_1002_jat_3733 crossref_primary_10_1002_etc_5819 crossref_primary_10_1016_j_envint_2023_108235 crossref_primary_10_1016_j_beem_2021_101495 crossref_primary_10_1093_toxsci_kfae073 crossref_primary_10_1016_j_scitotenv_2024_178331 crossref_primary_10_1002_etc_4723 crossref_primary_10_1016_j_scitotenv_2024_176274 crossref_primary_10_1021_acs_est_4c09874 crossref_primary_10_1039_D1EM00228G crossref_primary_10_1016_j_toxlet_2014_01_007 crossref_primary_10_1016_j_cej_2022_139964 crossref_primary_10_3390_ijms241813956 crossref_primary_10_1289_EHP9424 crossref_primary_10_1016_j_aquatox_2019_01_009 crossref_primary_10_1016_j_chemosphere_2021_131545 crossref_primary_10_1016_j_yrtph_2019_05_008 crossref_primary_10_1093_toxsci_kfae061 crossref_primary_10_1097_EE9_0000000000000199 crossref_primary_10_1016_j_jhazmat_2024_133743 crossref_primary_10_1080_10643389_2024_2306093 crossref_primary_10_1016_j_envpol_2023_122756 crossref_primary_10_1016_j_yrtph_2019_05_005 crossref_primary_10_1016_j_envres_2022_114644 crossref_primary_10_1007_s11356_022_23881_1 crossref_primary_10_1016_j_ijheh_2016_07_008 crossref_primary_10_1007_s11356_022_20829_3 crossref_primary_10_1289_EHP7431 crossref_primary_10_1016_j_scitotenv_2021_152446 crossref_primary_10_1021_acs_est_4c08480 crossref_primary_10_1016_j_envint_2020_105581 crossref_primary_10_1016_j_envres_2019_04_034 crossref_primary_10_3390_ijms25147788 crossref_primary_10_1016_j_envres_2023_117188 crossref_primary_10_1021_acs_est_4c09458 crossref_primary_10_1016_j_envres_2024_120638 crossref_primary_10_1016_j_envpol_2023_122429 crossref_primary_10_1007_s12020_019_02096_4 crossref_primary_10_1016_j_jhazmat_2025_137699 crossref_primary_10_1007_s00204_022_03405_z crossref_primary_10_1021_acs_est_1c00883 crossref_primary_10_1016_j_cej_2023_145064 crossref_primary_10_1016_j_scitotenv_2024_171653 crossref_primary_10_1016_j_envres_2019_108743 crossref_primary_10_1016_j_envint_2021_106600 crossref_primary_10_3390_ijms22042148 crossref_primary_10_1016_j_envres_2016_07_001 crossref_primary_10_1016_j_atmosenv_2023_119911 crossref_primary_10_1111_andr_12190 crossref_primary_10_1016_j_scitotenv_2017_06_031 crossref_primary_10_1016_j_toxrep_2022_12_006 crossref_primary_10_1016_j_envpol_2023_122698 crossref_primary_10_1016_j_arr_2023_101867 crossref_primary_10_1093_toxsci_kfac096 crossref_primary_10_1039_D4SU00152D crossref_primary_10_1016_j_tiv_2022_105412 crossref_primary_10_1016_j_envpol_2024_123937 crossref_primary_10_1007_s40572_014_0039_3 crossref_primary_10_1016_j_scitotenv_2024_173918 crossref_primary_10_1016_j_envint_2023_108167 crossref_primary_10_1016_j_scitotenv_2024_172840 crossref_primary_10_1002_etc_3726 crossref_primary_10_1016_j_ecoenv_2024_117399 crossref_primary_10_1007_s00128_022_03686_1 crossref_primary_10_1016_j_envint_2024_108582 crossref_primary_10_1016_j_scitotenv_2015_03_055 crossref_primary_10_1016_j_envint_2021_106982 crossref_primary_10_1016_j_tox_2024_153901 crossref_primary_10_1007_s00204_016_1836_2 crossref_primary_10_3390_ani14040529 crossref_primary_10_1016_j_envres_2023_117297 crossref_primary_10_1002_etc_4931 crossref_primary_10_1016_j_scitotenv_2023_161412 crossref_primary_10_1016_j_jhazmat_2023_131224 crossref_primary_10_1289_ehp_1307909 crossref_primary_10_3390_polym15224384 crossref_primary_10_1007_s00204_024_03685_7 crossref_primary_10_1016_j_envres_2022_114844 crossref_primary_10_1289_EHP10092 crossref_primary_10_1016_j_jhepr_2023_100694 crossref_primary_10_1016_j_fct_2018_07_031 crossref_primary_10_1016_j_chemosphere_2023_138585 |
| Cites_doi | 10.1016/j.chemosphere.2007.06.067 10.1016/j.neuro.2007.10.008 10.1002/rcm.2661 10.1897/02-553 10.1016/0009-2797(92)90003-4 10.1007/s11356-008-0040-1 10.1289/ehp.10009 10.1021/es020955c 10.1007/s00244-010-9628-9 10.1007/s00216-006-0451-0 10.1080/10590500903310047 10.1016/j.envres.2012.03.007 10.1093/toxsci/kfp029 10.1016/j.yrtph.2010.12.004 10.1289/ehp.1205829 10.1021/es200432n 10.1021/es900301s 10.1016/j.foodchem.2012.06.054 10.1021/jf300355c 10.1016/j.chemosphere.2008.11.054 10.1289/ehp.1003096 10.1016/j.envint.2010.04.016 10.1016/j.tox.2012.12.013 10.1007/s00244-009-9336-5 10.1021/es802827u 10.1007/s00244-009-9375-y 10.1016/j.envres.2004.12.003 10.1016/S0300-483X(02)00081-1 10.1080/10934529.2011.590383 10.1093/toxsci/kfp055 10.1016/j.chemosphere.2012.05.043 10.1089/thy.2009.0174 10.1289/ehp.1104325 10.1093/toxsci/kfm128 10.1016/j.reprotox.2011.04.006 10.1016/j.chroma.2008.10.113 10.1021/es2011622 10.1016/j.envint.2010.02.008 10.1097/01.jom.0000232486.07658.74 10.1016/j.envint.2009.01.010 10.1093/toxsci/kfn057 10.1016/j.envint.2007.01.003 10.1021/es101184f 10.1016/S0003-2670(02)00298-2 10.1016/j.envint.2011.09.004 |
| ContentType | Journal Article |
| Copyright | 2013 Elsevier Ltd 2014 INIST-CNRS Copyright © 2013 Elsevier Ltd. All rights reserved. |
| Copyright_xml | – notice: 2013 Elsevier Ltd – notice: 2014 INIST-CNRS – notice: Copyright © 2013 Elsevier Ltd. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 7ST 7TV C1K SOI 7SU 8FD FR3 7S9 L.6 DOA |
| DOI | 10.1016/j.envint.2013.06.004 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Environment Abstracts Pollution Abstracts Environmental Sciences and Pollution Management Environment Abstracts Environmental Engineering Abstracts Technology Research Database Engineering Research Database AGRICOLA AGRICOLA - Academic DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic Pollution Abstracts Environment Abstracts Environmental Sciences and Pollution Management Engineering Research Database Technology Research Database Environmental Engineering Abstracts AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | Engineering Research Database MEDLINE MEDLINE - Academic AGRICOLA Pollution Abstracts |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Engineering Public Health Environmental Sciences |
| EISSN | 1873-6750 |
| EndPage | 362 |
| ExternalDocumentID | oai_doaj_org_article_65146882455443529ddc56fcdd428d81 23892228 27716645 10_1016_j_envint_2013_06_004 S0160412013001220 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Spain, Cataluna, Tarragona Spain, Catalonia Spain |
| GeographicLocations_xml | – name: Spain, Catalonia – name: Spain, Cataluna, Tarragona – name: Spain |
| GroupedDBID | --- --K --M .~1 0R~ 0SF 1B1 1RT 1~. 1~5 29G 4.4 457 4G. 53G 5GY 5VS 6I. 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAFTH AAFWJ AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABEFU ABFNM ABFYP ABJNI ABLST ABMAC ABXDB ABYKQ ACDAQ ACGFS ACRLP ADEZE ADMUD AEBSH AEKER AENEX AFKWA AFPKN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHEUO AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AKIFW ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLECG BLXMC CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA GROUPED_DOAJ HMC HVGLF HZ~ IHE J1W K-O KCYFY KOM LY9 M41 MO0 N9A NCXOZ O-L O9- OAUVE OK1 OZT P-8 P-9 P2P PC. Q38 R2- RIG RNS ROL RPZ SCC SDF SDG SDP SEN SES SEW SSJ SSZ T5K TN5 WUQ XPP ~02 ~G- AAHBH AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO ADVLN AEGFY AEIPS AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH EFKBS IQODW CGR CUY CVF ECM EIF NPM 7X8 7ST 7TV C1K SOI 7SU 8FD FR3 7S9 L.6 |
| ID | FETCH-LOGICAL-c669t-9e25f0acf6e5fe16422415f34d61306d1b7198e55f13802f3c7dc62778dbdb2e3 |
| IEDL.DBID | DOA |
| ISSN | 0160-4120 1873-6750 |
| IngestDate | Wed Aug 27 01:16:16 EDT 2025 Fri Jul 11 05:26:34 EDT 2025 Fri Jul 11 11:21:36 EDT 2025 Mon Jul 21 09:18:01 EDT 2025 Thu Jul 10 22:49:37 EDT 2025 Mon Jul 21 05:23:35 EDT 2025 Mon Jul 21 09:16:30 EDT 2025 Tue Jul 01 01:23:03 EDT 2025 Thu Apr 24 22:53:27 EDT 2025 Fri Feb 23 02:37:07 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Human distribution Turbulent flow chromatography coupled to tandem mass spectrometry (TFC-LC-MS/MS) Tissues Perfluoroalkyl substances (PFASs) Principal Component Analysis Human Organic perhalocompound Metabolism Pollutant Tissue Mass spectrometry MS/MS Distribution Fluorine Organic compounds Biological accumulation Principal component analysis |
| Language | English |
| License | http://creativecommons.org/licenses/by-nc-nd/4.0 CC BY 4.0 Copyright © 2013 Elsevier Ltd. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c669t-9e25f0acf6e5fe16422415f34d61306d1b7198e55f13802f3c7dc62778dbdb2e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://doaj.org/article/65146882455443529ddc56fcdd428d81 |
| PMID | 23892228 |
| PQID | 1429848018 |
| PQPubID | 23462 |
| PageCount | 9 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_65146882455443529ddc56fcdd428d81 proquest_miscellaneous_1705431128 proquest_miscellaneous_1685770512 proquest_miscellaneous_1676358493 proquest_miscellaneous_1429848018 pubmed_primary_23892228 pascalfrancis_primary_27716645 crossref_primary_10_1016_j_envint_2013_06_004 crossref_citationtrail_10_1016_j_envint_2013_06_004 elsevier_sciencedirect_doi_10_1016_j_envint_2013_06_004 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2013-09-01 |
| PublicationDateYYYYMMDD | 2013-09-01 |
| PublicationDate_xml | – month: 09 year: 2013 text: 2013-09-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Oxford |
| PublicationPlace_xml | – name: Oxford – name: Netherlands |
| PublicationTitle | Environment international |
| PublicationTitleAlternate | Environ Int |
| PublicationYear | 2013 |
| Publisher | Elsevier Ltd Elsevier |
| Publisher_xml | – name: Elsevier Ltd – name: Elsevier |
| References | Rovira, Mari, Nadal, Schuhmacher, Domingo (bb0195) 2011; 46 Viberg, Lee, Eriksson (bb0220) 2013; 304 Post, Cohn, Cooper (bb0180) 2012; 116 Loi, Yeung, Taniyasu, Lam, Kannan, Yamashita (bb0130) 2011; 45 Navarro, Tauler, Lacorte, Barceló (bb0160) 2006; 385 Johansson, Eriksson, Viberg (bb0085) 2009; 108 Ericson, Domingo, Nadal, van Bavel, Lindström (bb0040) 2008; 15 Post, Louis, Cooper, Boros-Russo, Lippincott (bb0185) 2009; 43 Chang, Das, Ehresman, Ellefson, Gorman, Hart (bb0010) 2008; 104 Schecter, Malik-Bass, Calafat, Kato, Colacino, Gent (bb0205) 2012; 120 Vieira, Hoffman, Shin, Weinberg, Webster, Fletcher (bb0225) 2013; 121 Emmett, Shofer, Zhang, Freeman, Desai, Shaw (bb0035) 2006; 48 Lindstrom, Strynar, Libelo (bb0110) 2011; 45 Lau, Anitole, Hodes, Lai, Pfahles-Hutchens, Seed (bb0105) 2007; 99 Domingo, Ericson Jogsten, Eriksson, Martorell, Perelló, Nadal (bb0025) 2012; 135 Haug, Thomsen, Becher (bb0075) 2009; 1216 Domingo, Ericson-Jogsten, Perelló, Nadal, van Bavel, Kärrman (bb0020) 2012; 60 Luebker, Hansen, Bass, Butenhoff, Seacat (bb0135) 2002; 176 Harada, Inoue, Morikawa, Yoshinaga, Saito, Koizumi (bb0070) 2005; 99 Massart, Vandeginste, Buydens, de Jong, Lewi, Smeyers-Verbeke (bb0150) 1998 White, Birnbaum (bb0235) 2009; 27 Olsen, Burris, Ehresman, Froelich, Seacat, Butenhoff (bb0165) 2007; 115 Vanden Heuvel, Kuslikis, Peterson (bb0215) 1992; 82 Fromme, Mosch, Morovitz, Alba-Alejandre, Boehmer, Kiranoglu (bb0065) 2010; 44 Rovira, Mari, Schuhmacher, Nadal, Domingo (bb0200) 2011; 60 Maisonet, Terrell, McGeehin, Christensen, Holmes, Calafat (bb0145) 2012; 120 Thompson, Lorber, Toms, Kato, Calafat, Mueller (bb0210) 2010; 36 Ericson, Gómez, Nadal, van Bavel, Lindström, Domingo (bb0050) 2007; 33 Jones, Hu, de Coen, Newsted, Giesy (bb0095) 2003; 22 Powley, George, Russell, Hoke, Buck (bb0190) 2008; 70 Kärrman, Harada, Inoue, Takasuga, Ohi, Koizumi (bb0100) 2009; 35 Loccisano, Campbell, Butenhoff, Andersen, Clewell (bb0125) 2012; 33 Johansson, Fredriksson, Eriksson (bb0090) 2008; 29 Ericson, Domingo, Nadal, Bigas, Llebaria, van Bavel (bb0045) 2009; 57 Olsen, Hansen, Stevenson, Burris, Mandel (bb0170) 2003; 37 Llorca, Farré, Picó, Teijón, Álvarez, Barceló (bb0115) 2010; 36 Loccisano, Campbell, Andersen, Clewell (bb0120) 2011; 59 Weiss, Andersson, Lamoree, Leonards, Van Leeuwen, Hamers (bb0230) 2009; 109 Pirali, Negri, Chytiris, Perissi, Villani, La Manna (bb0175) 2009; 19 Brodnjak-Vončina, Dobčnik, Novič, Zupan (bb0005) 2002; 462 Haug, Thomsen, Becher (bb0080) 2009; 43 Cui, Liao, Zhou, Xia, Yun, Jiang (bb0015) 2010; 58 Ericson Jogsten, Nadal, van Bavel, Lindström, Domingo (bb0055) 2012; 39 Maestri, Negri, Ferrari, Ghittori, Fabris, Danesino (bb0140) 2006; 20 EFSA (bb0030) 2008; 653 Nadal, Domingo, García, Schuhmacher (bb0155) 2009; 74 Zhao, Wong, Wong (bb0240) 2012; 89 Fàbrega, Nadal, Schuhmacher, Domingo (bb0060) 2011; 73 Massart (10.1016/j.envint.2013.06.004_bb0150) 1998 Domingo (10.1016/j.envint.2013.06.004_bb0020) 2012; 60 Johansson (10.1016/j.envint.2013.06.004_bb0085) 2009; 108 Zhao (10.1016/j.envint.2013.06.004_bb0240) 2012; 89 Cui (10.1016/j.envint.2013.06.004_bb0015) 2010; 58 Rovira (10.1016/j.envint.2013.06.004_bb0195) 2011; 46 White (10.1016/j.envint.2013.06.004_bb0235) 2009; 27 Ericson (10.1016/j.envint.2013.06.004_bb0040) 2008; 15 Nadal (10.1016/j.envint.2013.06.004_bb0155) 2009; 74 Loccisano (10.1016/j.envint.2013.06.004_bb0125) 2012; 33 Olsen (10.1016/j.envint.2013.06.004_bb0165) 2007; 115 Maestri (10.1016/j.envint.2013.06.004_bb0140) 2006; 20 Jones (10.1016/j.envint.2013.06.004_bb0095) 2003; 22 Llorca (10.1016/j.envint.2013.06.004_bb0115) 2010; 36 Vieira (10.1016/j.envint.2013.06.004_bb0225) 2013; 121 Ericson (10.1016/j.envint.2013.06.004_bb0045) 2009; 57 Navarro (10.1016/j.envint.2013.06.004_bb0160) 2006; 385 Post (10.1016/j.envint.2013.06.004_bb0180) 2012; 116 EFSA (10.1016/j.envint.2013.06.004_bb0030) 2008; 653 Weiss (10.1016/j.envint.2013.06.004_bb0230) 2009; 109 Lindstrom (10.1016/j.envint.2013.06.004_bb0110) 2011; 45 Lau (10.1016/j.envint.2013.06.004_bb0105) 2007; 99 Fromme (10.1016/j.envint.2013.06.004_bb0065) 2010; 44 Haug (10.1016/j.envint.2013.06.004_bb0075) 2009; 1216 Powley (10.1016/j.envint.2013.06.004_bb0190) 2008; 70 Thompson (10.1016/j.envint.2013.06.004_bb0210) 2010; 36 Domingo (10.1016/j.envint.2013.06.004_bb0025) 2012; 135 Schecter (10.1016/j.envint.2013.06.004_bb0205) 2012; 120 Maisonet (10.1016/j.envint.2013.06.004_bb0145) 2012; 120 Vanden Heuvel (10.1016/j.envint.2013.06.004_bb0215) 1992; 82 Johansson (10.1016/j.envint.2013.06.004_bb0090) 2008; 29 Haug (10.1016/j.envint.2013.06.004_bb0080) 2009; 43 Post (10.1016/j.envint.2013.06.004_bb0185) 2009; 43 Ericson Jogsten (10.1016/j.envint.2013.06.004_bb0055) 2012; 39 Loccisano (10.1016/j.envint.2013.06.004_bb0120) 2011; 59 Loi (10.1016/j.envint.2013.06.004_bb0130) 2011; 45 Kärrman (10.1016/j.envint.2013.06.004_bb0100) 2009; 35 Harada (10.1016/j.envint.2013.06.004_bb0070) 2005; 99 Olsen (10.1016/j.envint.2013.06.004_bb0170) 2003; 37 Chang (10.1016/j.envint.2013.06.004_bb0010) 2008; 104 Ericson (10.1016/j.envint.2013.06.004_bb0050) 2007; 33 Fàbrega (10.1016/j.envint.2013.06.004_bb0060) 2011; 73 Pirali (10.1016/j.envint.2013.06.004_bb0175) 2009; 19 Brodnjak-Vončina (10.1016/j.envint.2013.06.004_bb0005) 2002; 462 Rovira (10.1016/j.envint.2013.06.004_bb0200) 2011; 60 Emmett (10.1016/j.envint.2013.06.004_bb0035) 2006; 48 Luebker (10.1016/j.envint.2013.06.004_bb0135) 2002; 176 Viberg (10.1016/j.envint.2013.06.004_bb0220) 2013; 304 |
| References_xml | – volume: 1216 start-page: 385 year: 2009 end-page: 393 ident: bb0075 article-title: A sensitive method for determination of a broad range of perfluorinated compounds in serum suitable for large-scale human biomonitoring publication-title: J Chromatogr A – volume: 70 start-page: 664 year: 2008 end-page: 672 ident: bb0190 article-title: Polyfluorinated chemicals in a spatially and temporally integrated food web in the Western Arctic publication-title: Chemosphere – volume: 60 start-page: 4408 year: 2012 end-page: 4415 ident: bb0020 article-title: Human exposure to perfluorinated compounds in Catalonia, Spain: contribution of drinking water and fish and shellfish publication-title: J Agric Food Chem – volume: 120 start-page: 590 year: 2012 end-page: 594 ident: bb0205 article-title: Polyfluoroalkyl compounds in Texas children from birth through 12 publication-title: Environ Health Perspect – volume: 33 start-page: 452 year: 2012 end-page: 467 ident: bb0125 article-title: Comparison and evaluation of pharmacokinetics of PFOA and PFOS in the adult rat using a physiologically based pharmacokinetic model publication-title: Reprod Toxicol – volume: 60 start-page: 372 year: 2011 end-page: 384 ident: bb0200 article-title: Monitoring environmental pollutants in the vicinity of a cement plant: a temporal study publication-title: Arch Environ Contam Toxicol – volume: 121 start-page: 318 year: 2013 end-page: 323 ident: bb0225 article-title: Perfluorooctanoic acid exposure and cancer outcomes in a contaminated community: a geographic analysis publication-title: Environ Health Perspect – volume: 48 start-page: 759 year: 2006 end-page: 770 ident: bb0035 article-title: Community exposure to perfluorooctanoate: relationships between serum concentrations and exposure sources publication-title: J Occup Environ Med – volume: 58 start-page: 205 year: 2010 end-page: 213 ident: bb0015 article-title: Excretion of PFOA and PFOS in male rats during a subchronic exposure publication-title: Arch Environ Contam Toxicol – volume: 116 start-page: 93 year: 2012 end-page: 117 ident: bb0180 article-title: Perfluorooctanoic acid (PFOA), an emerging drinking water contaminant: a critical review of recent literature publication-title: Environ Res – volume: 44 start-page: 7123 year: 2010 end-page: 7129 ident: bb0065 article-title: Pre- and postnatal exposure to perfluorinated compounds (PFCs) publication-title: Environ Sci Technol – volume: 109 start-page: 206 year: 2009 end-page: 216 ident: bb0230 article-title: Competitive binding of poly- and perfluorinated compounds to the thyroid hormone transport protein transthyretin publication-title: Toxicol Sci – volume: 176 start-page: 175 year: 2002 end-page: 185 ident: bb0135 article-title: Interactions of flurochemicals with rat liver fatty acid-binding protein publication-title: Toxicology – volume: 653 start-page: 1 year: 2008 end-page: 131 ident: bb0030 article-title: Opinion of the Scientific Panel on contaminants in the food chain on perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) and its salts (question no. EFSA-Q-2004-163) publication-title: EFSA J – volume: 45 start-page: 5506 year: 2011 end-page: 5513 ident: bb0130 article-title: Trophic magnification of poly- and perfluorinated compounds in a subtropical food web publication-title: Environ Sci Technol – volume: 19 start-page: 1407 year: 2009 end-page: 1412 ident: bb0175 article-title: Perfluorooctane sulfonate and perfluorooctanoic acid in surgical thyroid specimens of patients with thyroid diseases publication-title: Thyroid – volume: 22 start-page: 2639 year: 2003 end-page: 2649 ident: bb0095 article-title: Binding of perfluorinated fatty acids to serum proteins publication-title: Environ Toxicol Chem – volume: 73 start-page: 1169 year: 2011 end-page: 1172 ident: bb0060 article-title: PBPK modeling of PFOS and PFOA using a whole body pharmacokinetic model: a preliminary approach and validation test publication-title: Organohalogen Compd – volume: 304 start-page: 185 year: 2013 end-page: 191 ident: bb0220 article-title: Adult dose-dependent behavioral and cognitive disturbances after a single neonatal PFHxS dose publication-title: Toxicology – volume: 43 start-page: 4547 year: 2009 end-page: 4554 ident: bb0185 article-title: Occurrence and potential significance of perfluorooctanoic acid (PFOA) detected in New Jersey public drinking water systems publication-title: Environ Sci Technol – volume: 82 start-page: 317 year: 1992 end-page: 328 ident: bb0215 article-title: Covalent binding of perfluorinated fatty acids to proteins in the plasma, liver and testes of rats publication-title: Chem Biol Interact – volume: 89 start-page: 355 year: 2012 end-page: 368 ident: bb0240 article-title: Environmental contamination, human exposure and body loadings of perfluorooctane sulfonate (PFOS), focusing on Asian countries publication-title: Chemosphere – volume: 35 start-page: 712 year: 2009 end-page: 717 ident: bb0100 article-title: Relationship between dietary exposure and serum perfluorochemical (PFC) levels—a case study publication-title: Environ Int – volume: 15 start-page: 614 year: 2008 end-page: 619 ident: bb0040 article-title: Levels of perfluorochemicals in water samples from Catalonia, Spain: is drinking water a significant contribution to human exposure? publication-title: Environ Sci Pollut Res – volume: 29 start-page: 160 year: 2008 end-page: 169 ident: bb0090 article-title: Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice publication-title: Neurotoxicol – volume: 27 start-page: 197 year: 2009 end-page: 211 ident: bb0235 article-title: An overview of the effects of dioxins and dioxin-like compounds on vertebrates, as documented in human and ecological epidemiology publication-title: J Environ Sci Health C – volume: 59 start-page: 157 year: 2011 end-page: 175 ident: bb0120 article-title: Evaluation and prediction of pharmacokinetics of PFOA and PFOS in the monkey and human using a PBPK model publication-title: Regul Toxicol Pharmacol – volume: 135 start-page: 1575 year: 2012 end-page: 1582 ident: bb0025 article-title: Human dietary exposure to perfluoroalkyl substances in Catalonia Spain. Temporal trend publication-title: Food Chem – volume: 33 start-page: 616 year: 2007 end-page: 623 ident: bb0050 article-title: Perfluorinated chemicals in blood of residents in Catalonia (Spain) in relation to age and gender: a pilot study publication-title: Environ Int – volume: 45 start-page: 7954 year: 2011 end-page: 7961 ident: bb0110 article-title: Polyfluorinated compounds: past, present, and future publication-title: Environ Sci Technol – volume: 37 start-page: 888 year: 2003 end-page: 891 ident: bb0170 article-title: Human donor liver and serum concentrations of perfluorooctanesulfonate and other perfluorochemicals publication-title: Environ Sci Technol – volume: 120 start-page: 1 year: 2012 end-page: 26 ident: bb0145 article-title: Maternal concentrations of polyfluoroalkyl compounds during pregnancy and fetal and postnatal growth in British girls publication-title: Environ Health Perspect – volume: 385 start-page: 1020 year: 2006 end-page: 1030 ident: bb0160 article-title: Chemometrical investigation of the presence and distribution of organochlorine and polyaromatic compounds in sediments of the Ebro River Basin publication-title: Anal Bioanal Chem – volume: 36 start-page: 390 year: 2010 end-page: 397 ident: bb0210 article-title: Use of simple pharmacokinetic modeling to characterize exposure of Australians to perfluorooctanoic acid and perfluorooctane sulfonic acid publication-title: Environ Int – volume: 20 start-page: 2728 year: 2006 end-page: 2734 ident: bb0140 article-title: Determination of perfluorooctanoic acid and perfluorooctanesulfonate in human tissues by liquid chromatography/single quadrupole mass spectrometry publication-title: Rapid Commun Mass Spectrom – year: 1998 ident: bb0150 article-title: Handbook of chemometrics and qualimetrics: Part B – volume: 108 start-page: 412 year: 2009 end-page: 418 ident: bb0085 article-title: Neonatal exposure to PFOS and PFOA in mice results in changes in proteins which are important for neuronal growth and synaptogenesis in the developing brain publication-title: Toxicol Sci – volume: 46 start-page: 1075 year: 2011 end-page: 1084 ident: bb0195 article-title: Levels of metals and PCDD/Fs in the vicinity of a cement plant: assessment of human health risks publication-title: J Environ Sci Health A – volume: 39 start-page: 172 year: 2012 end-page: 180 ident: bb0055 article-title: Per- and polyfluorinated compounds (PFCs) in house dust and indoor air in Catalonia, Spain: implications for human exposure publication-title: Environ Int – volume: 99 start-page: 366 year: 2007 end-page: 394 ident: bb0105 article-title: Perfluoroalkyl acids: a review of monitoring and toxicological findings publication-title: Toxicol Sci – volume: 57 start-page: 631 year: 2009 end-page: 638 ident: bb0045 article-title: Levels of perfluorinated chemicals in municipal drinking water from Catalonia, Spain: public health implications publication-title: Arch Environ Contam Toxicol – volume: 74 start-page: 1471 year: 2009 end-page: 1476 ident: bb0155 article-title: Levels of PCDD/F in adipose tissue on non-occupationally exposed subjects living near a hazardous waste incinerator in Catalonia, Spain publication-title: Chemosphere – volume: 99 start-page: 253 year: 2005 end-page: 261 ident: bb0070 article-title: Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specific excretion publication-title: Environ Res – volume: 462 start-page: 87 year: 2002 end-page: 100 ident: bb0005 article-title: Chemometrics characterisation of the quality of river water publication-title: Anal Chim Acta – volume: 115 start-page: 1298 year: 2007 end-page: 1305 ident: bb0165 article-title: Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers publication-title: Environ Health Perspect – volume: 104 start-page: 40 year: 2008 end-page: 53 ident: bb0010 article-title: Comparative pharmacokinetics of perfluorobutyrate in rats, mice, monkeys, and humans and relevance to human exposure via drinking water publication-title: Toxicol Sci – volume: 43 start-page: 2131 year: 2009 end-page: 2136 ident: bb0080 article-title: Time trends and the influence of age and gender on serum concentrations of perfluorinated compounds in archived human samples publication-title: Environ Sci Technol – volume: 36 start-page: 584 year: 2010 end-page: 592 ident: bb0115 article-title: Infant exposure of perfluorinated compounds: levels in breast milk and commercial baby food publication-title: Environ Int – volume: 70 start-page: 664 year: 2008 ident: 10.1016/j.envint.2013.06.004_bb0190 article-title: Polyfluorinated chemicals in a spatially and temporally integrated food web in the Western Arctic publication-title: Chemosphere doi: 10.1016/j.chemosphere.2007.06.067 – volume: 29 start-page: 160 year: 2008 ident: 10.1016/j.envint.2013.06.004_bb0090 article-title: Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice publication-title: Neurotoxicol doi: 10.1016/j.neuro.2007.10.008 – volume: 20 start-page: 2728 year: 2006 ident: 10.1016/j.envint.2013.06.004_bb0140 article-title: Determination of perfluorooctanoic acid and perfluorooctanesulfonate in human tissues by liquid chromatography/single quadrupole mass spectrometry publication-title: Rapid Commun Mass Spectrom doi: 10.1002/rcm.2661 – volume: 22 start-page: 2639 year: 2003 ident: 10.1016/j.envint.2013.06.004_bb0095 article-title: Binding of perfluorinated fatty acids to serum proteins publication-title: Environ Toxicol Chem doi: 10.1897/02-553 – volume: 82 start-page: 317 year: 1992 ident: 10.1016/j.envint.2013.06.004_bb0215 article-title: Covalent binding of perfluorinated fatty acids to proteins in the plasma, liver and testes of rats publication-title: Chem Biol Interact doi: 10.1016/0009-2797(92)90003-4 – volume: 15 start-page: 614 year: 2008 ident: 10.1016/j.envint.2013.06.004_bb0040 article-title: Levels of perfluorochemicals in water samples from Catalonia, Spain: is drinking water a significant contribution to human exposure? publication-title: Environ Sci Pollut Res doi: 10.1007/s11356-008-0040-1 – volume: 115 start-page: 1298 year: 2007 ident: 10.1016/j.envint.2013.06.004_bb0165 article-title: Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers publication-title: Environ Health Perspect doi: 10.1289/ehp.10009 – volume: 37 start-page: 888 year: 2003 ident: 10.1016/j.envint.2013.06.004_bb0170 article-title: Human donor liver and serum concentrations of perfluorooctanesulfonate and other perfluorochemicals publication-title: Environ Sci Technol doi: 10.1021/es020955c – volume: 60 start-page: 372 year: 2011 ident: 10.1016/j.envint.2013.06.004_bb0200 article-title: Monitoring environmental pollutants in the vicinity of a cement plant: a temporal study publication-title: Arch Environ Contam Toxicol doi: 10.1007/s00244-010-9628-9 – volume: 385 start-page: 1020 year: 2006 ident: 10.1016/j.envint.2013.06.004_bb0160 article-title: Chemometrical investigation of the presence and distribution of organochlorine and polyaromatic compounds in sediments of the Ebro River Basin publication-title: Anal Bioanal Chem doi: 10.1007/s00216-006-0451-0 – volume: 27 start-page: 197 year: 2009 ident: 10.1016/j.envint.2013.06.004_bb0235 article-title: An overview of the effects of dioxins and dioxin-like compounds on vertebrates, as documented in human and ecological epidemiology publication-title: J Environ Sci Health C doi: 10.1080/10590500903310047 – volume: 116 start-page: 93 year: 2012 ident: 10.1016/j.envint.2013.06.004_bb0180 article-title: Perfluorooctanoic acid (PFOA), an emerging drinking water contaminant: a critical review of recent literature publication-title: Environ Res doi: 10.1016/j.envres.2012.03.007 – volume: 108 start-page: 412 year: 2009 ident: 10.1016/j.envint.2013.06.004_bb0085 article-title: Neonatal exposure to PFOS and PFOA in mice results in changes in proteins which are important for neuronal growth and synaptogenesis in the developing brain publication-title: Toxicol Sci doi: 10.1093/toxsci/kfp029 – volume: 59 start-page: 157 year: 2011 ident: 10.1016/j.envint.2013.06.004_bb0120 article-title: Evaluation and prediction of pharmacokinetics of PFOA and PFOS in the monkey and human using a PBPK model publication-title: Regul Toxicol Pharmacol doi: 10.1016/j.yrtph.2010.12.004 – volume: 121 start-page: 318 year: 2013 ident: 10.1016/j.envint.2013.06.004_bb0225 article-title: Perfluorooctanoic acid exposure and cancer outcomes in a contaminated community: a geographic analysis publication-title: Environ Health Perspect doi: 10.1289/ehp.1205829 – volume: 45 start-page: 5506 year: 2011 ident: 10.1016/j.envint.2013.06.004_bb0130 article-title: Trophic magnification of poly- and perfluorinated compounds in a subtropical food web publication-title: Environ Sci Technol doi: 10.1021/es200432n – volume: 43 start-page: 4547 year: 2009 ident: 10.1016/j.envint.2013.06.004_bb0185 article-title: Occurrence and potential significance of perfluorooctanoic acid (PFOA) detected in New Jersey public drinking water systems publication-title: Environ Sci Technol doi: 10.1021/es900301s – volume: 135 start-page: 1575 year: 2012 ident: 10.1016/j.envint.2013.06.004_bb0025 article-title: Human dietary exposure to perfluoroalkyl substances in Catalonia Spain. Temporal trend publication-title: Food Chem doi: 10.1016/j.foodchem.2012.06.054 – volume: 60 start-page: 4408 year: 2012 ident: 10.1016/j.envint.2013.06.004_bb0020 article-title: Human exposure to perfluorinated compounds in Catalonia, Spain: contribution of drinking water and fish and shellfish publication-title: J Agric Food Chem doi: 10.1021/jf300355c – year: 1998 ident: 10.1016/j.envint.2013.06.004_bb0150 – volume: 74 start-page: 1471 year: 2009 ident: 10.1016/j.envint.2013.06.004_bb0155 article-title: Levels of PCDD/F in adipose tissue on non-occupationally exposed subjects living near a hazardous waste incinerator in Catalonia, Spain publication-title: Chemosphere doi: 10.1016/j.chemosphere.2008.11.054 – volume: 120 start-page: 1 year: 2012 ident: 10.1016/j.envint.2013.06.004_bb0145 article-title: Maternal concentrations of polyfluoroalkyl compounds during pregnancy and fetal and postnatal growth in British girls publication-title: Environ Health Perspect doi: 10.1289/ehp.1003096 – volume: 36 start-page: 584 year: 2010 ident: 10.1016/j.envint.2013.06.004_bb0115 article-title: Infant exposure of perfluorinated compounds: levels in breast milk and commercial baby food publication-title: Environ Int doi: 10.1016/j.envint.2010.04.016 – volume: 304 start-page: 185 year: 2013 ident: 10.1016/j.envint.2013.06.004_bb0220 article-title: Adult dose-dependent behavioral and cognitive disturbances after a single neonatal PFHxS dose publication-title: Toxicology doi: 10.1016/j.tox.2012.12.013 – volume: 58 start-page: 205 year: 2010 ident: 10.1016/j.envint.2013.06.004_bb0015 article-title: Excretion of PFOA and PFOS in male rats during a subchronic exposure publication-title: Arch Environ Contam Toxicol doi: 10.1007/s00244-009-9336-5 – volume: 43 start-page: 2131 year: 2009 ident: 10.1016/j.envint.2013.06.004_bb0080 article-title: Time trends and the influence of age and gender on serum concentrations of perfluorinated compounds in archived human samples publication-title: Environ Sci Technol doi: 10.1021/es802827u – volume: 57 start-page: 631 year: 2009 ident: 10.1016/j.envint.2013.06.004_bb0045 article-title: Levels of perfluorinated chemicals in municipal drinking water from Catalonia, Spain: public health implications publication-title: Arch Environ Contam Toxicol doi: 10.1007/s00244-009-9375-y – volume: 99 start-page: 253 year: 2005 ident: 10.1016/j.envint.2013.06.004_bb0070 article-title: Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specific excretion publication-title: Environ Res doi: 10.1016/j.envres.2004.12.003 – volume: 176 start-page: 175 year: 2002 ident: 10.1016/j.envint.2013.06.004_bb0135 article-title: Interactions of flurochemicals with rat liver fatty acid-binding protein publication-title: Toxicology doi: 10.1016/S0300-483X(02)00081-1 – volume: 653 start-page: 1 year: 2008 ident: 10.1016/j.envint.2013.06.004_bb0030 article-title: Opinion of the Scientific Panel on contaminants in the food chain on perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) and its salts (question no. EFSA-Q-2004-163) publication-title: EFSA J – volume: 46 start-page: 1075 year: 2011 ident: 10.1016/j.envint.2013.06.004_bb0195 article-title: Levels of metals and PCDD/Fs in the vicinity of a cement plant: assessment of human health risks publication-title: J Environ Sci Health A doi: 10.1080/10934529.2011.590383 – volume: 109 start-page: 206 year: 2009 ident: 10.1016/j.envint.2013.06.004_bb0230 article-title: Competitive binding of poly- and perfluorinated compounds to the thyroid hormone transport protein transthyretin publication-title: Toxicol Sci doi: 10.1093/toxsci/kfp055 – volume: 89 start-page: 355 year: 2012 ident: 10.1016/j.envint.2013.06.004_bb0240 article-title: Environmental contamination, human exposure and body loadings of perfluorooctane sulfonate (PFOS), focusing on Asian countries publication-title: Chemosphere doi: 10.1016/j.chemosphere.2012.05.043 – volume: 19 start-page: 1407 year: 2009 ident: 10.1016/j.envint.2013.06.004_bb0175 article-title: Perfluorooctane sulfonate and perfluorooctanoic acid in surgical thyroid specimens of patients with thyroid diseases publication-title: Thyroid doi: 10.1089/thy.2009.0174 – volume: 120 start-page: 590 year: 2012 ident: 10.1016/j.envint.2013.06.004_bb0205 article-title: Polyfluoroalkyl compounds in Texas children from birth through 12years of age publication-title: Environ Health Perspect doi: 10.1289/ehp.1104325 – volume: 99 start-page: 366 year: 2007 ident: 10.1016/j.envint.2013.06.004_bb0105 article-title: Perfluoroalkyl acids: a review of monitoring and toxicological findings publication-title: Toxicol Sci doi: 10.1093/toxsci/kfm128 – volume: 33 start-page: 452 year: 2012 ident: 10.1016/j.envint.2013.06.004_bb0125 article-title: Comparison and evaluation of pharmacokinetics of PFOA and PFOS in the adult rat using a physiologically based pharmacokinetic model publication-title: Reprod Toxicol doi: 10.1016/j.reprotox.2011.04.006 – volume: 1216 start-page: 385 year: 2009 ident: 10.1016/j.envint.2013.06.004_bb0075 article-title: A sensitive method for determination of a broad range of perfluorinated compounds in serum suitable for large-scale human biomonitoring publication-title: J Chromatogr A doi: 10.1016/j.chroma.2008.10.113 – volume: 45 start-page: 7954 year: 2011 ident: 10.1016/j.envint.2013.06.004_bb0110 article-title: Polyfluorinated compounds: past, present, and future publication-title: Environ Sci Technol doi: 10.1021/es2011622 – volume: 36 start-page: 390 year: 2010 ident: 10.1016/j.envint.2013.06.004_bb0210 article-title: Use of simple pharmacokinetic modeling to characterize exposure of Australians to perfluorooctanoic acid and perfluorooctane sulfonic acid publication-title: Environ Int doi: 10.1016/j.envint.2010.02.008 – volume: 48 start-page: 759 year: 2006 ident: 10.1016/j.envint.2013.06.004_bb0035 article-title: Community exposure to perfluorooctanoate: relationships between serum concentrations and exposure sources publication-title: J Occup Environ Med doi: 10.1097/01.jom.0000232486.07658.74 – volume: 35 start-page: 712 year: 2009 ident: 10.1016/j.envint.2013.06.004_bb0100 article-title: Relationship between dietary exposure and serum perfluorochemical (PFC) levels—a case study publication-title: Environ Int doi: 10.1016/j.envint.2009.01.010 – volume: 104 start-page: 40 year: 2008 ident: 10.1016/j.envint.2013.06.004_bb0010 article-title: Comparative pharmacokinetics of perfluorobutyrate in rats, mice, monkeys, and humans and relevance to human exposure via drinking water publication-title: Toxicol Sci doi: 10.1093/toxsci/kfn057 – volume: 33 start-page: 616 year: 2007 ident: 10.1016/j.envint.2013.06.004_bb0050 article-title: Perfluorinated chemicals in blood of residents in Catalonia (Spain) in relation to age and gender: a pilot study publication-title: Environ Int doi: 10.1016/j.envint.2007.01.003 – volume: 44 start-page: 7123 year: 2010 ident: 10.1016/j.envint.2013.06.004_bb0065 article-title: Pre- and postnatal exposure to perfluorinated compounds (PFCs) publication-title: Environ Sci Technol doi: 10.1021/es101184f – volume: 462 start-page: 87 year: 2002 ident: 10.1016/j.envint.2013.06.004_bb0005 article-title: Chemometrics characterisation of the quality of river water publication-title: Anal Chim Acta doi: 10.1016/S0003-2670(02)00298-2 – volume: 39 start-page: 172 year: 2012 ident: 10.1016/j.envint.2013.06.004_bb0055 article-title: Per- and polyfluorinated compounds (PFCs) in house dust and indoor air in Catalonia, Spain: implications for human exposure publication-title: Environ Int doi: 10.1016/j.envint.2011.09.004 – volume: 73 start-page: 1169 year: 2011 ident: 10.1016/j.envint.2013.06.004_bb0060 article-title: PBPK modeling of PFOS and PFOA using a whole body pharmacokinetic model: a preliminary approach and validation test publication-title: Organohalogen Compd |
| SSID | ssj0002485 |
| Score | 2.5917401 |
| Snippet | Perfluoroalkyl substances (PFASs) are environmental pollutants with an important bioaccumulation potential. However, their metabolism and distribution in... |
| SourceID | doaj proquest pubmed pascalfrancis crossref elsevier |
| SourceType | Open Website Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 354 |
| SubjectTerms | Alkanesulfonic Acids - metabolism bioaccumulation Biological and medical sciences brain Caproates - metabolism Caprylates - metabolism Chromatography, Liquid Environment. Living conditions Environmental Monitoring Environmental Pollutants - metabolism Environmental pollutants toxicology Fluorocarbons - metabolism Human distribution Humans kidneys liquid chromatography liver Medical sciences necropsy Perfluoroalkyl substances (PFASs) perfluorocarbons pharmacokinetics pollutants Principal Component Analysis Public health. Hygiene Public health. Hygiene-occupational medicine solvents Spain sulfonic acids tandem mass spectrometry Tandem Mass Spectrometry - methods Tissue Distribution Tissues Toxicology turbulent flow Turbulent flow chromatography coupled to tandem mass spectrometry (TFC-LC-MS/MS) |
| SummonAdditionalLinks | – databaseName: Elsevier SD Freedom Collection dbid: .~1 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaqnkAVgoVCeFRB4ho2cfzkVqpWFRJcoFJvUeIHWtgmq032wIXfzozj7LIHthJXZ5JYM-PxjD3zDSHvtG8UlbnLPLjfGSsNz5QzTQajELp5iOUCxMbnL-L6hn265bdH5GKqhcG0ymj7R5serHUcmUduzleLxfwrYqOxguLVG94PYdzOmEQtf_97l-aBkF0jvneeIfVUPhdyvLCYrMWMyqIMKJ6xXdu0PQUU_71d6mRV98A7Pza9-LdXGnanq8fkUXQr0_Nx5k_IkWtn5OFfYIMzcnq5q2kD0rio-xk5GY_u0rEi6Sn5cG7M5i629Uo7n67c2i833bqrlz9_LdMebM2AytKnizYNTf7SIcivf0Zuri6_XVxnscVCZoTQQ6Yd5T6vjReOewehU9jRfcksxhXCFo0stHKc-6JUOfWlkdYIKqWyjW2oK0_Jcdu17gVJHc1rQbWVVofPaFYUDdeW27ymxjYJKSfOVibij2MbjGU1JZr9qEZ5VCiPKuTbsYRk27dWI_7GPfQfUWhbWkTPDgPd-nsV1acSHAvOFGUc0f84TNoaLryxFoIxq4qEyEnk1Z4ywqcW9_z-bE9DtvMAlhVCMJ6Qt5PKVLCQ8Xambl236SEGo1ohmI86QCMQP1AxXR6iUVxKsLX0AA08B88RfJOEPB_1djdTcGHxWPDlfzPhFXlAQ9MQzMR7TY6H9ca9AddtaM7C2vwDc-JAGA priority: 102 providerName: Elsevier |
| Title | Accumulation of perfluoroalkyl substances in human tissues |
| URI | https://dx.doi.org/10.1016/j.envint.2013.06.004 https://www.ncbi.nlm.nih.gov/pubmed/23892228 https://www.proquest.com/docview/1429848018 https://www.proquest.com/docview/1676358493 https://www.proquest.com/docview/1685770512 https://www.proquest.com/docview/1705431128 https://doaj.org/article/65146882455443529ddc56fcdd428d81 |
| Volume | 59 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9MwEB7BcgGtEBQWwqMyEtdA4sSOza2gXRUQe2KlvVmJH9JCSaomPXDhtzO2k-7ugfbCNZnmMTP2fJPOfAPwVrpG0CqzqUP4nZaFZqmwuknxKKZuDnO5QLHx7ZwvL8ovl-zyxqgvXxMW6YGj4t5z5puDBC2ZZ2pjVBqjGXfaGATOJjRdU4x5UzI17sGeqCuyemdpmdNsapoLlV2-haz1dZR5Ebg7xyFtU1AK3P23YtPxuu5RYy6Ouvg3Fg0x6ewRPBzBJFnEl3gMd2w7gwc3KAZncHJ63cmGouNS7mdwHD_YkdiH9AQ-LLTe_hqHeZHOkbXduNW223T16ufvFelxhxm8i_TkqiVhtB8ZgtX6p3Bxdvr90zIdByukmnM5pNJS5rJaO26Zs5gwhTjuitL4bIKbvKlyKSxjLi9ERl2hK6M5rSphGtNQW5zAUdu19jkQS7Oao1EqI8NlZJnnDZOGmaym2jQJFJNmlR5Zx_3wi5Wayst-qGgP5e2hQpVdmUC6-9U6sm4ckP_ojbaT9ZzZ4QB6kho9SR3ypASqyeRqhB8RVuClrg7cfn7LQ3bPgSrLOS9ZAm8ml1G4fP1_MnVru22PmReVwlP4iD0y3LMGilIW-2QEqyrcYekeGTyPeBERSQLPot9ePykCV_8x8MX_0ORLuE_D1BBfivcKjobN1r5G7DY0c7j77k8-h3uLz1-X5_OwaP8C6BNAPA |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED9N3QOgCUFhUD5GkHiNmjix4_BWpk0d2_rCJu0tSvyBCiWpmvaB_547x-noA53Eq3NJrLvz-c6--x3Ap9xWkmWRCS2632GaKB5Ko6oQRzF0sxjLOYiN65mY3qZf7_jdAZz2tTCUVultf2fTnbX2I2PPzfFyPh9_I2y0NGZ09Ub3Qxi3HxI6FR_A4eTicjrbGmRC7eogvqOQXugr6FyaF9WT1ZRUGScOyNN3bOt3KAfkv7NRHS3LFtlnu74X_3ZM3QZ1_gyees8ymHSTfw4Hph7Ck7_wBodwfHZf1oakfl23QzjqTu-CrijpBXyeKLX55Tt7BY0NlmZlF5tm1ZSLn78XQYvmZk360gbzOnB9_oK1E2H7Em7Pz25Op6HvshAqIfJ1mBvGbVQqKwy3BqMnt6nbJNUUWggdV1mcS8O5jRMZMZuoTCvBskzqSlfMJMcwqJvavIbAsKgULNeZzt1n8jSOK55rrqOSKV2NIOk5WygPQU6dMBZFn2v2o-jkUZA8Cpdyl44g3L617CA4HqD_QkLb0hKAthtoVt8Lr0GF4FRzJlnKCQCQ46S14sIqrTEe0zIeQdaLvNjRR_zU_IHfn-xoyHYeyLJYiJSP4GOvMgWuZbqgKWvTbFoMw1guCc9H7qERBCEo0zzZRyN5lqG5ZXto8Dk6j-iejOBVp7f3M0Uvlk4G3_w3Ez7Ao-nN9VVxdTG7fAuPmeshQol572CwXm3Me_Tk1tWJX6l_AGAERFc |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Accumulation+of+perfluoroalkyl+substances+in+human+tissues&rft.jtitle=Environment+international&rft.au=P%C3%A9rez+Prado%2C+Francisca&rft.au=Nadal%2C+Mart%C3%AD&rft.au=Navarro-Ortega%2C+Al%C3%ADcia&rft.au=F%C3%A0brega%2C+Francesc&rft.date=2013-09-01&rft.issn=0160-4120&rft.volume=59+p.354-362&rft.spage=354&rft.epage=362&rft_id=info:doi/10.1016%2Fj.envint.2013.06.004&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0160-4120&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0160-4120&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0160-4120&client=summon |