IMRAS—A clinical trial of mosquito-bite immunization with live, radiation-attenuated P. falciparum sporozoites: Impact of immunization parameters on protective efficacy and generation of a repository of immunologic reagents

• Published in: PloS one Vol. 15; no. 6; p. e0233840
• Main Authors: Hickey, Bradley, Teneza-Mora, Nimfa, Lumsden, Joanne, Reyes, Sharina, Sedegah, Martha, Garver, Lindsey, Hollingdale, Michael R., Banania, Jo Glenna, Ganeshan, Harini, Dowler, Megan, Reyes, Anatalio, Tamminga, Cindy, Singer, Alexandra, Simmons, Alicia, Belmonte, Maria, Belmonte, Arnel, Huang, Jun, Inoue, Sandra, Velasco, Rachel, Abot, Steve, Vasquez, Carlos S., Guzman, Ivelese, Wong, Mimi, Twomey, Patrick, Wojnarski, Mariusz, Moon, James, Alcorta, Yolanda, Maiolatesi, Santina, Spring, Michele, Davidson, Silas, Chaudhury, Sidhartha, Villasante, Eileen, Richie, Thomas L., Epstein, Judith E.
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 17.06.2020; Public Library of Science (PLoS)
• Subjects: Antibodies; Antigens; Aquatic insects; Biology and Life Sciences; CD8 antigen; Clinical trials; Dose-response relationship; Health aspects; Hepatocytes; Homology; Immune response; Immunization; Immunology; Infectivity; Insect bites; Leukapheresis; Leukocytes (mononuclear); Liver; Lymphocytes; Lymphocytes T; Malaria; Medical research; Medicine and Health Sciences; Mosquitoes; Parameters; Parasites; Peptides; Peripheral blood mononuclear cells; Plasmodium falciparum; Prevention; R&D; Radiation; Reagents; Research & development; Research and Analysis Methods; Salivary gland; Salivary glands; Sporozoites; Testing; Vaccine efficacy; Vaccines; Vector-borne diseases; γ-Interferon; United States; United States > US

Immunization with radiation-attenuated sporozoites (RAS) by mosquito bite provides >90% sterile protection against Plasmodium falciparum (Pf) malaria in humans. RAS invade hepatocytes but do not replicate. CD8+ T cells recognizing parasite-derived peptides on the surface of infected hepatocytes a...