PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects

• Published in: EJNMMI research Vol. 8; no. 1; pp. 57 - 9
• Main Authors: Richards, Erica M., Zanotti-Fregonara, Paolo, Fujita, Masahiro, Newman, Laura, Farmer, Cristan, Ballard, Elizabeth D., Machado-Vieira, Rodrigo, Yuan, Peixiong, Niciu, Mark J., Lyoo, Chul Hyoung, Henter, Ioline D., Salvadore, Giacomo, Drevets, Wayne C., Kolb, Hartmuth, Innis, Robert B., Zarate Jr, Carlos A.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 03.07.2018; Springer Nature B.V; SpringerOpen
• Subjects: Antidepressants; Binding; Biomarkers; Cardiac Imaging; Cerebrospinal fluid; Imaging; Inflammation; Interleukins; Major depressive disorder; Medicine; Medicine & Public Health; Mental depression; Nuclear Medicine; Oncology; Original Research; Orthopedics; Peripheral benzodiazepine receptor; Positron emission; Positron emission tomography; Proteins; Radiology; Statistical analysis; Statistical methods; Tomography; Biomarkers; Peripheral benzodiazepine receptor; Inflammation; Positron emission tomography; Major depressive disorder

Background Inflammation is associated with major depressive disorder (MDD). Translocator protein 18 kDa (TSPO), a putative biomarker of neuroinflammation, is quantified using positron emission tomography (PET) and 11 C-PBR28, a TSPO tracer. We sought to (1) investigate TSPO binding in MDD subjects c...