Non-invasive skin sampling detects systemically administered drugs in humans

• Published in: PloS one Vol. 17; no. 7; p. e0271794
• Main Authors: Panitchpakdi, Morgan, Weldon, Kelly C., Jarmusch, Alan K., Gentry, Emily C., Choi, Arianna, Sepulveda, Yadira, Aguirre, Shaden, Sun, Kunyang, Momper, Jeremiah D., Dorrestein, Pieter C., Tsunoda, Shirley M.
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 26.07.2022; Public Library of Science (PLoS)
• Subjects: Biology and Life Sciences; Biopsy; Blood; Caffeine; Chemicals; Chronic illnesses; Diphenhydramine; Dosage and administration; Drug metabolism; Drug utilization; Drugs; Ethanol; Mass spectrometry; Mass spectroscopy; Medicine and Health Sciences; Metabolism; Metabolites; Metabolomics; Methods; Oral administration; Pharmacology, Experimental; Physical Sciences; Physiological aspects; Plasma; Plasma levels; Sampling; Sampling methods; Skin; Skin tests; United States; United States > US

Clinical testing typically relies on invasive blood draws and biopsies. Alternative methods of sample collection are continually being developed to improve patient experience; swabbing the skin is one of the least invasive sampling methods possible. To show that skin swabs in combination with untarg...