Identification and validation of circulating miRNAs as potential new biomarkers for severe liver disease in patients with leptospirosis

• Published in: PloS one Vol. 16; no. 9; p. e0257805
• Main Authors: Chuaypen, Natthaya, Limothai, Umaporn, Kunadirek, Pattapon, Kaewsapsak, Pornchai, Kueanjinda, Patipark, Srisawat, Nattachai, Tangkijvanich, Pisit
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 27.09.2021; Public Library of Science (PLoS)
• Subjects: Analysis; Biochemistry; Biological markers; Biology and life sciences; Biomarkers; Complications and side effects; Computer and Information Sciences; Critical care; Diagnosis; Engineering and Technology; Failure analysis; Gene expression; Genetic aspects; Hepatitis; Immune response; Infectious diseases; Leptospirosis; Liver; Liver cancer; Liver diseases; Medical prognosis; Medicine; Medicine and Health Sciences; MicroRNA; MicroRNAs; miRNA; Mortality; Nephrology; Ontology; Patients; Proteins; Regression analysis; Risk factors; Survival; Tropical diseases; Zoonoses; Thailand; United States > US; Bangkok Thailand

Background Leptospirosis, a global zoonotic infectious disease, has various clinical manifestations ranging from mild self-limiting illness to life-threatening with multi-organ damage, including liver involvement. This study was aimed at identifying circulating microRNAs (miRNAs) as novel biomarkers...